The efficacy of moisturisers containing ceramide compared with other moisturisers in the management of atopic dermatitis: A systematic literature review and meta-analysis
Atopic dermatitis (AD), also known as atopic eczema, is a chronic inflammatory skin condition that recurs frequently and has diverse clinical features. The main mechanism of AD is the dysfunction of the skin-epidermal barrier. One of the causes of stratum corneum (SC) structural integrity disruption...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=1;spage=53;epage=58;aulast=Nugroho |
| _version_ | 1797824349342793728 |
|---|---|
| author | Wisnu Triadi Nugroho Sawitri Sawitri Astindari Astindari Budi Utomo M Yulianto Listiawan Evy Ervianti Linda Astari |
| author_facet | Wisnu Triadi Nugroho Sawitri Sawitri Astindari Astindari Budi Utomo M Yulianto Listiawan Evy Ervianti Linda Astari |
| author_sort | Wisnu Triadi Nugroho |
| collection | DOAJ |
| description | Atopic dermatitis (AD), also known as atopic eczema, is a chronic inflammatory skin condition that recurs frequently and has diverse clinical features. The main mechanism of AD is the dysfunction of the skin-epidermal barrier. One of the causes of stratum corneum (SC) structural integrity disruption is the decreased production of ceramide, an important lipid component in SC. The latest generation of moisturisers contain ceramide to help replace this lipid deficit. This study aimed to compare the efficacy of moisturisers containing ceramide with other moisturisers for AD management. Searches were conducted systematically on PubMed, the Cochrane Library, ScienceDirect, Clinicaltrials.gov, and Google Scholar for studies published from January 2012 to July 2022. Interventions and outcomes were compared in this study. Statistical analysis was performed with ReviewManager 5.4 software. Five articles met the eligibility and inclusion criteria. Three articles were meta-analyses on trans-epidermal water loss (TEWL) outcomes and two articles were meta-analyses on SCORing Atopic Dermatitis (SCORAD) outcomes. A meta-analysis of TEWL results found that TEWL values were not significantly different in subjects treated with ceramide-containing moisturisers (mean difference: −3.56, 95% CI [−8.63, 1.52], P = 0.17) with high heterogeneity (I2 = 92%) compared to other treatments. The change in SCORAD was significantly higher in moisturisers containing ceramide (mean difference: −0.98, 95% CI [−1.63, −0.33], P = 0.003) with low heterogeneity (I2 = 0%). Moisturisers containing ceramide improve SCORAD and TEWL; however only the changes in SCORAD in moisturisers containing ceramide is superior to other moisturisers. |
| first_indexed | 2024-03-13T10:37:39Z |
| format | Article |
| id | doaj.art-09449656fcc148c4a791a2a28d0e376b |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-03-13T10:37:39Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-09449656fcc148c4a791a2a28d0e376b2023-05-18T05:27:54ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112023-01-01681535810.4103/ijd.ijd_991_22The efficacy of moisturisers containing ceramide compared with other moisturisers in the management of atopic dermatitis: A systematic literature review and meta-analysisWisnu Triadi NugrohoSawitri SawitriAstindari AstindariBudi UtomoM Yulianto ListiawanEvy ErviantiLinda AstariAtopic dermatitis (AD), also known as atopic eczema, is a chronic inflammatory skin condition that recurs frequently and has diverse clinical features. The main mechanism of AD is the dysfunction of the skin-epidermal barrier. One of the causes of stratum corneum (SC) structural integrity disruption is the decreased production of ceramide, an important lipid component in SC. The latest generation of moisturisers contain ceramide to help replace this lipid deficit. This study aimed to compare the efficacy of moisturisers containing ceramide with other moisturisers for AD management. Searches were conducted systematically on PubMed, the Cochrane Library, ScienceDirect, Clinicaltrials.gov, and Google Scholar for studies published from January 2012 to July 2022. Interventions and outcomes were compared in this study. Statistical analysis was performed with ReviewManager 5.4 software. Five articles met the eligibility and inclusion criteria. Three articles were meta-analyses on trans-epidermal water loss (TEWL) outcomes and two articles were meta-analyses on SCORing Atopic Dermatitis (SCORAD) outcomes. A meta-analysis of TEWL results found that TEWL values were not significantly different in subjects treated with ceramide-containing moisturisers (mean difference: −3.56, 95% CI [−8.63, 1.52], P = 0.17) with high heterogeneity (I2 = 92%) compared to other treatments. The change in SCORAD was significantly higher in moisturisers containing ceramide (mean difference: −0.98, 95% CI [−1.63, −0.33], P = 0.003) with low heterogeneity (I2 = 0%). Moisturisers containing ceramide improve SCORAD and TEWL; however only the changes in SCORAD in moisturisers containing ceramide is superior to other moisturisers.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=1;spage=53;epage=58;aulast=Nugrohoatopic dermatitisceramidemoisturiserscoradtewl |
| spellingShingle | Wisnu Triadi Nugroho Sawitri Sawitri Astindari Astindari Budi Utomo M Yulianto Listiawan Evy Ervianti Linda Astari The efficacy of moisturisers containing ceramide compared with other moisturisers in the management of atopic dermatitis: A systematic literature review and meta-analysis Indian Journal of Dermatology atopic dermatitis ceramide moisturiser scorad tewl |
| title | The efficacy of moisturisers containing ceramide compared with other moisturisers in the management of atopic dermatitis: A systematic literature review and meta-analysis |
| title_full | The efficacy of moisturisers containing ceramide compared with other moisturisers in the management of atopic dermatitis: A systematic literature review and meta-analysis |
| title_fullStr | The efficacy of moisturisers containing ceramide compared with other moisturisers in the management of atopic dermatitis: A systematic literature review and meta-analysis |
| title_full_unstemmed | The efficacy of moisturisers containing ceramide compared with other moisturisers in the management of atopic dermatitis: A systematic literature review and meta-analysis |
| title_short | The efficacy of moisturisers containing ceramide compared with other moisturisers in the management of atopic dermatitis: A systematic literature review and meta-analysis |
| title_sort | efficacy of moisturisers containing ceramide compared with other moisturisers in the management of atopic dermatitis a systematic literature review and meta analysis |
| topic | atopic dermatitis ceramide moisturiser scorad tewl |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2023;volume=68;issue=1;spage=53;epage=58;aulast=Nugroho |
| work_keys_str_mv | AT wisnutriadinugroho theefficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT sawitrisawitri theefficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT astindariastindari theefficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT budiutomo theefficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT myuliantolistiawan theefficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT evyervianti theefficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT lindaastari theefficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT wisnutriadinugroho efficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT sawitrisawitri efficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT astindariastindari efficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT budiutomo efficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT myuliantolistiawan efficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT evyervianti efficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis AT lindaastari efficacyofmoisturiserscontainingceramidecomparedwithothermoisturisersinthemanagementofatopicdermatitisasystematicliteraturereviewandmetaanalysis |