Characteristics, Management and In-Hospital Clinical Outcomes Among Inpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in China: Results from the Phase I Data of ACURE Study
Chen Liang,1 Xihua Mao,1 Hongtao Niu,2– 4 Ke Huang,2– 4 Fen Dong,2– 5 Yahong Chen,6 Kewu Huang,7,8 Qingyuan Zhan,2– 4 Yin Huang,1 Yaowen Zhang,1 Ting Yang,2– 4 Chen Wang2– 4,9 1Chinese Alliance for Respiratory Diseases in Primary Care, Beij...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-02-01
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| Series: | International Journal of COPD |
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| Online Access: | https://www.dovepress.com/characteristics-management-and-in-hospital-clinical-outcomes-among-inp-peer-reviewed-article-COPD |
| _version_ | 1818662951271268352 |
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| author | Liang C Mao X Niu H Huang K Dong F Chen Y Huang K Zhan Q Huang Y Zhang Y Yang T Wang C |
| author_facet | Liang C Mao X Niu H Huang K Dong F Chen Y Huang K Zhan Q Huang Y Zhang Y Yang T Wang C |
| author_sort | Liang C |
| collection | DOAJ |
| description | Chen Liang,1 Xihua Mao,1 Hongtao Niu,2– 4 Ke Huang,2– 4 Fen Dong,2– 5 Yahong Chen,6 Kewu Huang,7,8 Qingyuan Zhan,2– 4 Yin Huang,1 Yaowen Zhang,1 Ting Yang,2– 4 Chen Wang2– 4,9 1Chinese Alliance for Respiratory Diseases in Primary Care, Beijing, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 3National Clinical Research Center for Respiratory Diseases, Beijing, People’s Republic of China; 4Institute of Respiratory Medicine, Chinese Academy of Medical Science, Beijing, People’s Republic of China; 5Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 6Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, People’s Republic of China; 7Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Beijing, People’s Republic of China; 8Department of Respiratory Medicine, Capital Medical University, Beijing, People’s Republic of China; 9Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Ting YangDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, No. 2, East Yinghua Road, Chaoyang District, Beijing, 100029, People’s Republic of ChinaEmail zryyyangting@163.comChen WangChinese Academy of Medical Sciences and Peking Union Medical College, 9 Dongdan 3rd Alley, Dong Dan, Dongcheng, Beijing, 100730, People’s Republic of ChinaEmail cyh-birm@263.netPurpose: The study aimed to give a comprehensive overview of characteristics and evaluate in-hospital clinical outcomes among hospitalized acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients in China using data from the AECOPD inpatient registry (ACURE).Patients and Methods: The ACURE is an ongoing, national, multicenter, observational registry. Participants enrolled during phase I stage (1st September 2017 to 25th February 2020) of ACURE with confirmed AECOPD diagnoses were studied. Descriptive analyses were conducted to describe features and occurrences of in-hospital clinical outcomes of AECOPD inpatients in real-world China.Results: A total of 5334 AECOPD inpatients from 163 sites in 28 provinces or province-level municipalities were included. Among all participants, 78.8% were males and the median age was 69.0 [interquartile range (IQR): 63.0– 76.0] years. The proportions of current and former smokers were 23.6% and 44.2%, respectively. The median age at COPD diagnosis was 64.0 (IQR: 57.0– 71.0) years and 88.7% participants demonstrated at least one comorbidity. During stable period, only 56.9% subjects received pharmacological therapies and the influenza vaccination rate was 2.9%. During hospitalization, 99.5% subjects received pharmacological treatments and antibiotics were prescribed to 90.9% participants. The all-cause in-hospital mortality was 0.1% and no significant difference was found across hospital categories.Conclusion: Clinical features of Chinese AECOPD inpatients were different from those of other populations. In real-world China, the clinical management during stable period was unsatisfied, whereas therapy during hospitalization was effective regarding in-hospital clinical outcomes regardless of hospital category.Keywords: registries, demography, therapeutics, disease management, hospital mortality, public health |
| first_indexed | 2024-12-17T05:09:06Z |
| format | Article |
| id | doaj.art-09454f00ba2e4aa589e53601103ac936 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-17T05:09:06Z |
| publishDate | 2021-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-09454f00ba2e4aa589e53601103ac9362022-12-21T22:02:18ZengDove Medical PressInternational Journal of COPD1178-20052021-02-01Volume 1645146562512Characteristics, Management and In-Hospital Clinical Outcomes Among Inpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in China: Results from the Phase I Data of ACURE StudyLiang CMao XNiu HHuang KDong FChen YHuang KZhan QHuang YZhang YYang TWang CChen Liang,1 Xihua Mao,1 Hongtao Niu,2– 4 Ke Huang,2– 4 Fen Dong,2– 5 Yahong Chen,6 Kewu Huang,7,8 Qingyuan Zhan,2– 4 Yin Huang,1 Yaowen Zhang,1 Ting Yang,2– 4 Chen Wang2– 4,9 1Chinese Alliance for Respiratory Diseases in Primary Care, Beijing, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 3National Clinical Research Center for Respiratory Diseases, Beijing, People’s Republic of China; 4Institute of Respiratory Medicine, Chinese Academy of Medical Science, Beijing, People’s Republic of China; 5Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 6Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, People’s Republic of China; 7Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Beijing, People’s Republic of China; 8Department of Respiratory Medicine, Capital Medical University, Beijing, People’s Republic of China; 9Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Ting YangDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, No. 2, East Yinghua Road, Chaoyang District, Beijing, 100029, People’s Republic of ChinaEmail zryyyangting@163.comChen WangChinese Academy of Medical Sciences and Peking Union Medical College, 9 Dongdan 3rd Alley, Dong Dan, Dongcheng, Beijing, 100730, People’s Republic of ChinaEmail cyh-birm@263.netPurpose: The study aimed to give a comprehensive overview of characteristics and evaluate in-hospital clinical outcomes among hospitalized acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients in China using data from the AECOPD inpatient registry (ACURE).Patients and Methods: The ACURE is an ongoing, national, multicenter, observational registry. Participants enrolled during phase I stage (1st September 2017 to 25th February 2020) of ACURE with confirmed AECOPD diagnoses were studied. Descriptive analyses were conducted to describe features and occurrences of in-hospital clinical outcomes of AECOPD inpatients in real-world China.Results: A total of 5334 AECOPD inpatients from 163 sites in 28 provinces or province-level municipalities were included. Among all participants, 78.8% were males and the median age was 69.0 [interquartile range (IQR): 63.0– 76.0] years. The proportions of current and former smokers were 23.6% and 44.2%, respectively. The median age at COPD diagnosis was 64.0 (IQR: 57.0– 71.0) years and 88.7% participants demonstrated at least one comorbidity. During stable period, only 56.9% subjects received pharmacological therapies and the influenza vaccination rate was 2.9%. During hospitalization, 99.5% subjects received pharmacological treatments and antibiotics were prescribed to 90.9% participants. The all-cause in-hospital mortality was 0.1% and no significant difference was found across hospital categories.Conclusion: Clinical features of Chinese AECOPD inpatients were different from those of other populations. In real-world China, the clinical management during stable period was unsatisfied, whereas therapy during hospitalization was effective regarding in-hospital clinical outcomes regardless of hospital category.Keywords: registries, demography, therapeutics, disease management, hospital mortality, public healthhttps://www.dovepress.com/characteristics-management-and-in-hospital-clinical-outcomes-among-inp-peer-reviewed-article-COPDregistriesdemographytherapeuticsdisease managementhospital mortalitypublic health |
| spellingShingle | Liang C Mao X Niu H Huang K Dong F Chen Y Huang K Zhan Q Huang Y Zhang Y Yang T Wang C Characteristics, Management and In-Hospital Clinical Outcomes Among Inpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in China: Results from the Phase I Data of ACURE Study International Journal of COPD registries demography therapeutics disease management hospital mortality public health |
| title | Characteristics, Management and In-Hospital Clinical Outcomes Among Inpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in China: Results from the Phase I Data of ACURE Study |
| title_full | Characteristics, Management and In-Hospital Clinical Outcomes Among Inpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in China: Results from the Phase I Data of ACURE Study |
| title_fullStr | Characteristics, Management and In-Hospital Clinical Outcomes Among Inpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in China: Results from the Phase I Data of ACURE Study |
| title_full_unstemmed | Characteristics, Management and In-Hospital Clinical Outcomes Among Inpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in China: Results from the Phase I Data of ACURE Study |
| title_short | Characteristics, Management and In-Hospital Clinical Outcomes Among Inpatients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in China: Results from the Phase I Data of ACURE Study |
| title_sort | characteristics management and in hospital clinical outcomes among inpatients with acute exacerbation of chronic obstructive pulmonary disease in china results from the phase i data of acure study |
| topic | registries demography therapeutics disease management hospital mortality public health |
| url | https://www.dovepress.com/characteristics-management-and-in-hospital-clinical-outcomes-among-inp-peer-reviewed-article-COPD |
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