Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteins
<p>Abstract</p> <p>The Influenza A virus non-structural protein 1 (NS1) is a multifunctional virulence factor with several protein-protein interaction domains, involved in preventing apoptosis of the infected cell and in evading the interferon response. In addition, the majority of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-01-01
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| Series: | Virology Journal |
| Online Access: | http://www.virologyj.com/content/8/1/25 |
| _version_ | 1818449609138110464 |
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| author | Nagasaka Kazunori Kranjec Christian Thomas Miranda Matlashewski Greg Banks Lawrence |
| author_facet | Nagasaka Kazunori Kranjec Christian Thomas Miranda Matlashewski Greg Banks Lawrence |
| author_sort | Nagasaka Kazunori |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The Influenza A virus non-structural protein 1 (NS1) is a multifunctional virulence factor with several protein-protein interaction domains, involved in preventing apoptosis of the infected cell and in evading the interferon response. In addition, the majority of influenza A virus NS1 proteins have a class I PDZ-binding motif at the C-terminus, and this itself has been shown to be a virulence determinant.</p> <p>In the majority of human influenza NS1 proteins the consensus motif is RSxV: in avian NS1 it is ESxV. Of the few human strains that have the avian motif, all were from very high mortality outbreaks of the disease. Previous work has shown that minor differences in PDZ-binding motifs can have major effects on the spectrum of cellular proteins targeted. In this study we analyse the effect of these differences upon the binding of Influenza A virus NS1 protein to a range of cellular proteins involved in polarity and signal transduction.</p> |
| first_indexed | 2024-12-14T20:38:07Z |
| format | Article |
| id | doaj.art-09455494467d497aa55a221afdb27fa4 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-14T20:38:07Z |
| publishDate | 2011-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-09455494467d497aa55a221afdb27fa42022-12-21T22:48:21ZengBMCVirology Journal1743-422X2011-01-01812510.1186/1743-422X-8-25Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteinsNagasaka KazunoriKranjec ChristianThomas MirandaMatlashewski GregBanks Lawrence<p>Abstract</p> <p>The Influenza A virus non-structural protein 1 (NS1) is a multifunctional virulence factor with several protein-protein interaction domains, involved in preventing apoptosis of the infected cell and in evading the interferon response. In addition, the majority of influenza A virus NS1 proteins have a class I PDZ-binding motif at the C-terminus, and this itself has been shown to be a virulence determinant.</p> <p>In the majority of human influenza NS1 proteins the consensus motif is RSxV: in avian NS1 it is ESxV. Of the few human strains that have the avian motif, all were from very high mortality outbreaks of the disease. Previous work has shown that minor differences in PDZ-binding motifs can have major effects on the spectrum of cellular proteins targeted. In this study we analyse the effect of these differences upon the binding of Influenza A virus NS1 protein to a range of cellular proteins involved in polarity and signal transduction.</p>http://www.virologyj.com/content/8/1/25 |
| spellingShingle | Nagasaka Kazunori Kranjec Christian Thomas Miranda Matlashewski Greg Banks Lawrence Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteins Virology Journal |
| title | Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteins |
| title_full | Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteins |
| title_fullStr | Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteins |
| title_full_unstemmed | Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteins |
| title_short | Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteins |
| title_sort | analysis of the pdz binding specificities of influenza a virus ns1 proteins |
| url | http://www.virologyj.com/content/8/1/25 |
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