A pharmacokinetic study on red ginseng with furosemide in equine
Red ginseng (RG) is a popular ingredient in traditional Korean medicine that has various health benefits. It is commonly taken orally as a dietary supplement; however, its potential interactions with concomitantly administered drugs are unclear. In this study, we examined the pharmacokinetic interac...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1319998/full |
| _version_ | 1797464941790232576 |
|---|---|
| author | Young Beom Kwak Eunkyu Lee Hyunjoo Choi Taemook Park Ahram Kim Jungon Kim Jungho Yoon Hye Hyun Yoo |
| author_facet | Young Beom Kwak Eunkyu Lee Hyunjoo Choi Taemook Park Ahram Kim Jungon Kim Jungho Yoon Hye Hyun Yoo |
| author_sort | Young Beom Kwak |
| collection | DOAJ |
| description | Red ginseng (RG) is a popular ingredient in traditional Korean medicine that has various health benefits. It is commonly taken orally as a dietary supplement; however, its potential interactions with concomitantly administered drugs are unclear. In this study, we examined the pharmacokinetic interaction between furosemide and RG in equine plasma. Liquid chromatography with tandem mass spectrometry analysis was performed to evaluate ginsenosides in the plasma of horses after feeding them RG and furosemide and validate the results. A single bolus of furosemide (0.5 mg/kg) was administered intravenously to female horses that had consumed RG (600 mg/kg/day) every morning for 3 weeks (experimental group), and blood samples were collected from 0 to 24 h, analyzed, and compared with those from female horses that did not consume RG (control group). Four (20s)-protopanaxadiol ginsenosides (Rb1, Rb2, Rc, and Rd) were detected in the plasma. Rb1 and Rc individually showed a high concentration distribution in the plasma. The Cmax, AUC0−t, and AUC0−∞ of furosemide was significantly increased in the experimental group (p < 0.05), while the CL, Vz, and Vss was decreased (p < 0.05, p < 0.01). These changes indicate the potential for pharmacokinetic interactions between furosemide and RG. |
| first_indexed | 2024-03-09T18:14:22Z |
| format | Article |
| id | doaj.art-0945c633877444f9a9f0ae9cf81402c8 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-09T18:14:22Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-0945c633877444f9a9f0ae9cf81402c82023-11-24T08:48:05ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-11-011010.3389/fvets.2023.13199981319998A pharmacokinetic study on red ginseng with furosemide in equineYoung Beom Kwak0Eunkyu Lee1Hyunjoo Choi2Taemook Park3Ahram Kim4Jungon Kim5Jungho Yoon6Hye Hyun Yoo7Racing Laboratory, Korea Racing Authority, Jeju-si, Jeju, Republic of KoreaInstitute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of KoreaTraining Support Team, Jeju Stud Farm, Korea Racing Authority, Jeju-si, Jeju, Republic of KoreaEquine Clinic, Korea Racing Authority, Jeju-si, Jeju, Republic of KoreaEquine Clinic, Jeju Stud Farm, Korea Racing Authority, Jeju-si, Jeju, Republic of KoreaManagement Team, Jeju Stud Farm, Korea Racing Authority, Jeju-si, Jeju, Republic of KoreaEquine Clinic, Jeju Stud Farm, Korea Racing Authority, Jeju-si, Jeju, Republic of KoreaInstitute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of KoreaRed ginseng (RG) is a popular ingredient in traditional Korean medicine that has various health benefits. It is commonly taken orally as a dietary supplement; however, its potential interactions with concomitantly administered drugs are unclear. In this study, we examined the pharmacokinetic interaction between furosemide and RG in equine plasma. Liquid chromatography with tandem mass spectrometry analysis was performed to evaluate ginsenosides in the plasma of horses after feeding them RG and furosemide and validate the results. A single bolus of furosemide (0.5 mg/kg) was administered intravenously to female horses that had consumed RG (600 mg/kg/day) every morning for 3 weeks (experimental group), and blood samples were collected from 0 to 24 h, analyzed, and compared with those from female horses that did not consume RG (control group). Four (20s)-protopanaxadiol ginsenosides (Rb1, Rb2, Rc, and Rd) were detected in the plasma. Rb1 and Rc individually showed a high concentration distribution in the plasma. The Cmax, AUC0−t, and AUC0−∞ of furosemide was significantly increased in the experimental group (p < 0.05), while the CL, Vz, and Vss was decreased (p < 0.05, p < 0.01). These changes indicate the potential for pharmacokinetic interactions between furosemide and RG.https://www.frontiersin.org/articles/10.3389/fvets.2023.1319998/fullred ginsengfurosemideherb-drug interactionequinepharmacokinetics |
| spellingShingle | Young Beom Kwak Eunkyu Lee Hyunjoo Choi Taemook Park Ahram Kim Jungon Kim Jungho Yoon Hye Hyun Yoo A pharmacokinetic study on red ginseng with furosemide in equine Frontiers in Veterinary Science red ginseng furosemide herb-drug interaction equine pharmacokinetics |
| title | A pharmacokinetic study on red ginseng with furosemide in equine |
| title_full | A pharmacokinetic study on red ginseng with furosemide in equine |
| title_fullStr | A pharmacokinetic study on red ginseng with furosemide in equine |
| title_full_unstemmed | A pharmacokinetic study on red ginseng with furosemide in equine |
| title_short | A pharmacokinetic study on red ginseng with furosemide in equine |
| title_sort | pharmacokinetic study on red ginseng with furosemide in equine |
| topic | red ginseng furosemide herb-drug interaction equine pharmacokinetics |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1319998/full |
| work_keys_str_mv | AT youngbeomkwak apharmacokineticstudyonredginsengwithfurosemideinequine AT eunkyulee apharmacokineticstudyonredginsengwithfurosemideinequine AT hyunjoochoi apharmacokineticstudyonredginsengwithfurosemideinequine AT taemookpark apharmacokineticstudyonredginsengwithfurosemideinequine AT ahramkim apharmacokineticstudyonredginsengwithfurosemideinequine AT jungonkim apharmacokineticstudyonredginsengwithfurosemideinequine AT junghoyoon apharmacokineticstudyonredginsengwithfurosemideinequine AT hyehyunyoo apharmacokineticstudyonredginsengwithfurosemideinequine AT youngbeomkwak pharmacokineticstudyonredginsengwithfurosemideinequine AT eunkyulee pharmacokineticstudyonredginsengwithfurosemideinequine AT hyunjoochoi pharmacokineticstudyonredginsengwithfurosemideinequine AT taemookpark pharmacokineticstudyonredginsengwithfurosemideinequine AT ahramkim pharmacokineticstudyonredginsengwithfurosemideinequine AT jungonkim pharmacokineticstudyonredginsengwithfurosemideinequine AT junghoyoon pharmacokineticstudyonredginsengwithfurosemideinequine AT hyehyunyoo pharmacokineticstudyonredginsengwithfurosemideinequine |