Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI
Abstract Parkinson’s disease (PD) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (NM)-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN). How regional NM loss and iron accumulation within specific areas of SN relate to nigro-...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-07-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-021-00199-2 |
| _version_ | 1797428066248556544 |
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| author | Frédérique Depierreux Eric Parmentier Laurane Mackels Katherine Baquero Christian Degueldre Evelyne Balteau Eric Salmon Christophe Phillips Mohamed Ali Bahri Pierre Maquet Gaëtan Garraux |
| author_facet | Frédérique Depierreux Eric Parmentier Laurane Mackels Katherine Baquero Christian Degueldre Evelyne Balteau Eric Salmon Christophe Phillips Mohamed Ali Bahri Pierre Maquet Gaëtan Garraux |
| author_sort | Frédérique Depierreux |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (NM)-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN). How regional NM loss and iron accumulation within specific areas of SN relate to nigro-striatal dysfunction needs to be clarified. We measured dopaminergic function in pre- and postcommissural putamen by [18F]DOPA PET in 23 Parkinson’s disease patients and 23 healthy control (HC) participants in whom NM content and iron load were assessed in medial and lateral SN, respectively, by NM-sensitive and quantitative R2* MRI. Data analysis consisted of voxelwise regressions testing the group effect and its interaction with NM or iron signals. In PD patients, R2* was selectively increased in left lateral SN as compared to healthy participants, suggesting a local accumulation of iron in Parkinson’s disease. By contrast, NM signal differed between PD and HC, without specific regional specificity within SN. Dopaminergic function in posterior putamen decreased as R2* increased in lateral SN, indicating that dopaminergic function impairment progresses with iron accumulation in the SN. Dopaminergic function was also positively correlated with NM signal in lateral SN, indicating that dopaminergic function impairment progresses with depigmentation in the SN. A complex relationship was detected between R2* in the lateral SN and NM signal in the medial SN. In conclusion, multimodal imaging reveals regionally specific relationships between iron accumulation and depigmentation within the SN of Parkinson’s disease and provides in vivo insights in its neuropathology. |
| first_indexed | 2024-03-09T08:52:46Z |
| format | Article |
| id | doaj.art-0946553028454154b53ef1778f32be08 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-09T08:52:46Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-0946553028454154b53ef1778f32be082023-12-02T13:42:46ZengNature Portfolionpj Parkinson's Disease2373-80572021-07-017111010.1038/s41531-021-00199-2Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRIFrédérique Depierreux0Eric Parmentier1Laurane Mackels2Katherine Baquero3Christian Degueldre4Evelyne Balteau5Eric Salmon6Christophe Phillips7Mohamed Ali Bahri8Pierre Maquet9Gaëtan Garraux10GIGA-CRC In Vivo Imaging, University of LiègeGIGA-CRC In Vivo Imaging, University of LiègeDepartment of Neurology, University Hospital of LiègeGIGA-CRC In Vivo Imaging, University of LiègeGIGA-CRC In Vivo Imaging, University of LiègeGIGA-CRC In Vivo Imaging, University of LiègeGIGA-CRC In Vivo Imaging, University of LiègeGIGA-CRC In Vivo Imaging, University of LiègeGIGA-CRC In Vivo Imaging, University of LiègeGIGA-CRC In Vivo Imaging, University of LiègeGIGA-CRC In Vivo Imaging, University of LiègeAbstract Parkinson’s disease (PD) is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin (NM)-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN). How regional NM loss and iron accumulation within specific areas of SN relate to nigro-striatal dysfunction needs to be clarified. We measured dopaminergic function in pre- and postcommissural putamen by [18F]DOPA PET in 23 Parkinson’s disease patients and 23 healthy control (HC) participants in whom NM content and iron load were assessed in medial and lateral SN, respectively, by NM-sensitive and quantitative R2* MRI. Data analysis consisted of voxelwise regressions testing the group effect and its interaction with NM or iron signals. In PD patients, R2* was selectively increased in left lateral SN as compared to healthy participants, suggesting a local accumulation of iron in Parkinson’s disease. By contrast, NM signal differed between PD and HC, without specific regional specificity within SN. Dopaminergic function in posterior putamen decreased as R2* increased in lateral SN, indicating that dopaminergic function impairment progresses with iron accumulation in the SN. Dopaminergic function was also positively correlated with NM signal in lateral SN, indicating that dopaminergic function impairment progresses with depigmentation in the SN. A complex relationship was detected between R2* in the lateral SN and NM signal in the medial SN. In conclusion, multimodal imaging reveals regionally specific relationships between iron accumulation and depigmentation within the SN of Parkinson’s disease and provides in vivo insights in its neuropathology.https://doi.org/10.1038/s41531-021-00199-2 |
| spellingShingle | Frédérique Depierreux Eric Parmentier Laurane Mackels Katherine Baquero Christian Degueldre Evelyne Balteau Eric Salmon Christophe Phillips Mohamed Ali Bahri Pierre Maquet Gaëtan Garraux Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI npj Parkinson's Disease |
| title | Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI |
| title_full | Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI |
| title_fullStr | Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI |
| title_full_unstemmed | Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI |
| title_short | Parkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI |
| title_sort | parkinson s disease multimodal imaging f dopa pet neuromelanin sensitive and quantitative iron sensitive mri |
| url | https://doi.org/10.1038/s41531-021-00199-2 |
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