Identifying Hmga2 preserving visual function by promoting a shift of Müller glia cell fate in mice with acute retinal injury

Identifying Hmga2 preserving visual function by promoting a shift of Müller glia cell fate in mice with acute retinal injury

Abstract Background Unlike in lower vertebrates, Müller glia (MG) in adult mammalian retinas lack the ability to reprogram into neurons after retinal injury or degeneration and exhibit reactive gliosis instead. Whether a transition in MG cell fate from gliosis to reprogramming would help preserve ph...

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Bibliographic Details
Main Authors: Zhiyuan Yin, Lingling Ge, Zhe Cha, Hui Gao, Luodan A, Yuxiao Zeng, Xiaona Huang, Xuan Cheng, Kai Yao, Zui Tao, Haiwei Xu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Stem Cell Research & Therapy
Subjects:
Hmga2
Müller glia
Gliosis
Reprogramming
Epigenetic
Proliferation
Online Access:https://doi.org/10.1186/s13287-024-03657-9

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