“Cheerios in the lung” as first metastases from endometrial endometrioid adenocarcinoma with adequate response to immunotherapy
Abstract Background Metastases from endometrial carcinoma to the lungs are uncommon and cavitating metastases are even rarer. In some cases, lung cavitating metastases may resemble diffuse “Cheerios in the lung.” Case presentation A 58-year-old woman, smoker, with a history of hysteroannessiectomy a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-09-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-023-01079-w |
| _version_ | 1827723885308542976 |
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| author | Chiara De Nardo Nicholas Landini Michele Massaro Angelina Pernazza Francesca Arienzo Marco Bicchetti Valeria Panebianco Carlo Catalano |
| author_facet | Chiara De Nardo Nicholas Landini Michele Massaro Angelina Pernazza Francesca Arienzo Marco Bicchetti Valeria Panebianco Carlo Catalano |
| author_sort | Chiara De Nardo |
| collection | DOAJ |
| description | Abstract Background Metastases from endometrial carcinoma to the lungs are uncommon and cavitating metastases are even rarer. In some cases, lung cavitating metastases may resemble diffuse “Cheerios in the lung.” Case presentation A 58-year-old woman, smoker, with a history of hysteroannessiectomy and pelvic lymphadenectomy for a low stage endometrial endometrioid adenocarcinoma, came under our attention for dry cough without fever that persisted for over three months, and computed tomography (CT) revealed diffuse cavitating lung metastases resembling "Cheerios in the lung". After standard chemotherapy proved ineffective, Lenvatinib plus Pembrolizumab (immunotherapy) was administrated, leading to the disappearance of all lung nodules, leaving behind a diffuse emphysematous-like pattern. Conclusions This case is a rare example of metastatic endometrioid adenocarcinoma, manifested with chronic dry cough, with “Cheerios in the lung” appearence. The metastases responded well to immunotherapy, resulting in the regression of nodules into areas of diffuse emphysematous-like changes. |
| first_indexed | 2024-03-10T22:06:00Z |
| format | Article |
| id | doaj.art-0947cc5008f0468ca8e4890d65ca6c77 |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-03-10T22:06:00Z |
| publishDate | 2023-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-0947cc5008f0468ca8e4890d65ca6c772023-11-19T12:46:31ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622023-09-015411510.1186/s43055-023-01079-w“Cheerios in the lung” as first metastases from endometrial endometrioid adenocarcinoma with adequate response to immunotherapyChiara De Nardo0Nicholas Landini1Michele Massaro2Angelina Pernazza3Francesca Arienzo4Marco Bicchetti5Valeria Panebianco6Carlo Catalano7Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, “Sapienza” UniversityDepartment of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, “Sapienza” UniversityDepartment of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, “Sapienza” UniversityDepartment of Medico-Surgical Sciences and Biotechnologies, Polo Pontino-Sapienza UniversityDepartment of Medico-Surgical Sciences and Biotechnologies, Polo Pontino-Sapienza UniversityDepartment of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, “Sapienza” UniversityDepartment of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, “Sapienza” UniversityDepartment of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, “Sapienza” UniversityAbstract Background Metastases from endometrial carcinoma to the lungs are uncommon and cavitating metastases are even rarer. In some cases, lung cavitating metastases may resemble diffuse “Cheerios in the lung.” Case presentation A 58-year-old woman, smoker, with a history of hysteroannessiectomy and pelvic lymphadenectomy for a low stage endometrial endometrioid adenocarcinoma, came under our attention for dry cough without fever that persisted for over three months, and computed tomography (CT) revealed diffuse cavitating lung metastases resembling "Cheerios in the lung". After standard chemotherapy proved ineffective, Lenvatinib plus Pembrolizumab (immunotherapy) was administrated, leading to the disappearance of all lung nodules, leaving behind a diffuse emphysematous-like pattern. Conclusions This case is a rare example of metastatic endometrioid adenocarcinoma, manifested with chronic dry cough, with “Cheerios in the lung” appearence. The metastases responded well to immunotherapy, resulting in the regression of nodules into areas of diffuse emphysematous-like changes.https://doi.org/10.1186/s43055-023-01079-wLung metastasesEndometrial endometrioid adenocarcinomaImmunotherapy |
| spellingShingle | Chiara De Nardo Nicholas Landini Michele Massaro Angelina Pernazza Francesca Arienzo Marco Bicchetti Valeria Panebianco Carlo Catalano “Cheerios in the lung” as first metastases from endometrial endometrioid adenocarcinoma with adequate response to immunotherapy The Egyptian Journal of Radiology and Nuclear Medicine Lung metastases Endometrial endometrioid adenocarcinoma Immunotherapy |
| title | “Cheerios in the lung” as first metastases from endometrial endometrioid adenocarcinoma with adequate response to immunotherapy |
| title_full | “Cheerios in the lung” as first metastases from endometrial endometrioid adenocarcinoma with adequate response to immunotherapy |
| title_fullStr | “Cheerios in the lung” as first metastases from endometrial endometrioid adenocarcinoma with adequate response to immunotherapy |
| title_full_unstemmed | “Cheerios in the lung” as first metastases from endometrial endometrioid adenocarcinoma with adequate response to immunotherapy |
| title_short | “Cheerios in the lung” as first metastases from endometrial endometrioid adenocarcinoma with adequate response to immunotherapy |
| title_sort | cheerios in the lung as first metastases from endometrial endometrioid adenocarcinoma with adequate response to immunotherapy |
| topic | Lung metastases Endometrial endometrioid adenocarcinoma Immunotherapy |
| url | https://doi.org/10.1186/s43055-023-01079-w |
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