Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons
Shape memory alloys, especially ferromagnetic shape memory alloys, are interesting new materials for the manufacturing of stents. Iron–palladium alloys in particular can be used to manufacture self-expanding temporary stents due to their optimum rate of degradation, which is between that of magnesiu...
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MDPI AG
2023-01-01
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author | Alexander Bunge Alexandru Chiriac Mihaela Sofronie Izabell Crăciunescu Alin Sebastian Porav Rodica Turcu |
author_facet | Alexander Bunge Alexandru Chiriac Mihaela Sofronie Izabell Crăciunescu Alin Sebastian Porav Rodica Turcu |
author_sort | Alexander Bunge |
collection | DOAJ |
description | Shape memory alloys, especially ferromagnetic shape memory alloys, are interesting new materials for the manufacturing of stents. Iron–palladium alloys in particular can be used to manufacture self-expanding temporary stents due to their optimum rate of degradation, which is between that of magnesium and pure iron, two metals commonly used in temporary stent research. In order to avoid blood clotting upon the introduction of the stent, they are often coated with anticoagulants. In this study, sulfated pectin, a heparin mimetic, was synthesized in different ways and used as coating on multiple iron–palladium alloys. The static and dynamic prothrombin time (PT) and activated partial thromboplastin time (APTT) of the prepared materials were compared to samples uncoated or coated with polyethylene glycol. While no large differences were observed in the prothrombin time measurements, the activated partial thromboplastin time increased significantly with all alloys coated with sulfated pectin. Aside from that, sulfated pectin synthesized by different methods also caused slight changes in the activated partial thromboplastin time. These findings show that iron–palladium alloys can be coated with anticoagulants to improve their utility as material for temporary stents. Sulfated pectin was characterized by nuclear magnetic resonance (NMR) and Fourier-transform infrared (FTIR) spectroscopy, and the coated alloys by scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). |
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language | English |
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spelling | doaj.art-094acefd2e0d45ca901581436446919b2023-11-16T16:57:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243245210.3390/ijms24032452Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory RibbonsAlexander Bunge0Alexandru Chiriac1Mihaela Sofronie2Izabell Crăciunescu3Alin Sebastian Porav4Rodica Turcu5National Institute R&D for Isotopic and Molecular Technology, 67-103 Donat Street, 400293 Cluj-Napoca, RomaniaDepartment of Neurosurgery, “Grigore T. Popa” University of Medicine and Pharmacy, Str. Universității nr. 16, 700115 Iasi, RomaniaNational Institute of Materials Physics, Atomistilor Street 405A, 077125 Magurele, RomaniaNational Institute R&D for Isotopic and Molecular Technology, 67-103 Donat Street, 400293 Cluj-Napoca, RomaniaNational Institute R&D for Isotopic and Molecular Technology, 67-103 Donat Street, 400293 Cluj-Napoca, RomaniaNational Institute R&D for Isotopic and Molecular Technology, 67-103 Donat Street, 400293 Cluj-Napoca, RomaniaShape memory alloys, especially ferromagnetic shape memory alloys, are interesting new materials for the manufacturing of stents. Iron–palladium alloys in particular can be used to manufacture self-expanding temporary stents due to their optimum rate of degradation, which is between that of magnesium and pure iron, two metals commonly used in temporary stent research. In order to avoid blood clotting upon the introduction of the stent, they are often coated with anticoagulants. In this study, sulfated pectin, a heparin mimetic, was synthesized in different ways and used as coating on multiple iron–palladium alloys. The static and dynamic prothrombin time (PT) and activated partial thromboplastin time (APTT) of the prepared materials were compared to samples uncoated or coated with polyethylene glycol. While no large differences were observed in the prothrombin time measurements, the activated partial thromboplastin time increased significantly with all alloys coated with sulfated pectin. Aside from that, sulfated pectin synthesized by different methods also caused slight changes in the activated partial thromboplastin time. These findings show that iron–palladium alloys can be coated with anticoagulants to improve their utility as material for temporary stents. Sulfated pectin was characterized by nuclear magnetic resonance (NMR) and Fourier-transform infrared (FTIR) spectroscopy, and the coated alloys by scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX).https://www.mdpi.com/1422-0067/24/3/2452anticoagulantsulfated pectinferromagnetic shape memory alloymelt spinningiron–palladium alloy |
spellingShingle | Alexander Bunge Alexandru Chiriac Mihaela Sofronie Izabell Crăciunescu Alin Sebastian Porav Rodica Turcu Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons International Journal of Molecular Sciences anticoagulant sulfated pectin ferromagnetic shape memory alloy melt spinning iron–palladium alloy |
title | Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title_full | Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title_fullStr | Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title_full_unstemmed | Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title_short | Anticoagulant Properties of Coated Fe-Pd Ferromagnetic Shape Memory Ribbons |
title_sort | anticoagulant properties of coated fe pd ferromagnetic shape memory ribbons |
topic | anticoagulant sulfated pectin ferromagnetic shape memory alloy melt spinning iron–palladium alloy |
url | https://www.mdpi.com/1422-0067/24/3/2452 |
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