A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

Endocytosis of transmembrane proteins is orchestrated by the AP2 clathrin adaptor complex. AP2 dwells in a closed, inactive state in the cytosol, but adopts an open, active conformation on the plasma membrane. Membrane-activated complexes are also phosphorylated, but the significance of this mark is...

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Bibliographic Details
Main Authors: Edward A Partlow, Richard W Baker, Gwendolyn M Beacham, Joshua S Chappie, Andres E Leschziner, Gunther Hollopeter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
endocytosis
clathrin adaptor
phosphorylation
NECAP
cryo-EM
genetic screen
Online Access:https://elifesciences.org/articles/50003

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