Dedifferentiated fat cells: current applications and future directions in regenerative medicine
Abstract Stem cell therapy is the most promising treatment option for regenerative medicine. Therapeutic effect of different stem cells has been verified in various disease model. Dedifferentiated fat (DFAT) cells, derived from mature adipocytes, are induced pluripotent stem cells. Compared with ASC...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03399-0 |
| _version_ | 1797577717127839744 |
|---|---|
| author | Zhuokai Liang Yufei He Haojing Tang Jian Li Junrong Cai Yunjun Liao |
| author_facet | Zhuokai Liang Yufei He Haojing Tang Jian Li Junrong Cai Yunjun Liao |
| author_sort | Zhuokai Liang |
| collection | DOAJ |
| description | Abstract Stem cell therapy is the most promising treatment option for regenerative medicine. Therapeutic effect of different stem cells has been verified in various disease model. Dedifferentiated fat (DFAT) cells, derived from mature adipocytes, are induced pluripotent stem cells. Compared with ASCs and other stem cells, the DFAT cells have unique advantageous characteristics in their abundant sources, high homogeneity, easily harvest and low immunogenicity. The DFAT cells have shown great potential in tissue engineering and regenerative medicine for the treatment of clinical problems such as cardiac and kidney diseases, autoimmune disease, soft and hard tissue defect. In this review, we summarize the current understanding of DFAT cell properties and focus on the relevant practical applications of DFAT cells in cell therapy in recent years. |
| first_indexed | 2024-03-10T22:11:58Z |
| format | Article |
| id | doaj.art-094bcdfad9044aa4bc821c5f3a28c36b |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-03-10T22:11:58Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-094bcdfad9044aa4bc821c5f3a28c36b2023-11-19T12:33:26ZengBMCStem Cell Research & Therapy1757-65122023-08-0114111410.1186/s13287-023-03399-0Dedifferentiated fat cells: current applications and future directions in regenerative medicineZhuokai Liang0Yufei He1Haojing Tang2Jian Li3Junrong Cai4Yunjun Liao5Department of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical UniversityDepartment of Plastic and Reconstructive Surgery, Nanfang Hospital, Southern Medical UniversityAbstract Stem cell therapy is the most promising treatment option for regenerative medicine. Therapeutic effect of different stem cells has been verified in various disease model. Dedifferentiated fat (DFAT) cells, derived from mature adipocytes, are induced pluripotent stem cells. Compared with ASCs and other stem cells, the DFAT cells have unique advantageous characteristics in their abundant sources, high homogeneity, easily harvest and low immunogenicity. The DFAT cells have shown great potential in tissue engineering and regenerative medicine for the treatment of clinical problems such as cardiac and kidney diseases, autoimmune disease, soft and hard tissue defect. In this review, we summarize the current understanding of DFAT cell properties and focus on the relevant practical applications of DFAT cells in cell therapy in recent years.https://doi.org/10.1186/s13287-023-03399-0Dedifferentiated fat cellsRegenerative medicineCell therapyDifferentiationSecretionRedifferentiation |
| spellingShingle | Zhuokai Liang Yufei He Haojing Tang Jian Li Junrong Cai Yunjun Liao Dedifferentiated fat cells: current applications and future directions in regenerative medicine Stem Cell Research & Therapy Dedifferentiated fat cells Regenerative medicine Cell therapy Differentiation Secretion Redifferentiation |
| title | Dedifferentiated fat cells: current applications and future directions in regenerative medicine |
| title_full | Dedifferentiated fat cells: current applications and future directions in regenerative medicine |
| title_fullStr | Dedifferentiated fat cells: current applications and future directions in regenerative medicine |
| title_full_unstemmed | Dedifferentiated fat cells: current applications and future directions in regenerative medicine |
| title_short | Dedifferentiated fat cells: current applications and future directions in regenerative medicine |
| title_sort | dedifferentiated fat cells current applications and future directions in regenerative medicine |
| topic | Dedifferentiated fat cells Regenerative medicine Cell therapy Differentiation Secretion Redifferentiation |
| url | https://doi.org/10.1186/s13287-023-03399-0 |
| work_keys_str_mv | AT zhuokailiang dedifferentiatedfatcellscurrentapplicationsandfuturedirectionsinregenerativemedicine AT yufeihe dedifferentiatedfatcellscurrentapplicationsandfuturedirectionsinregenerativemedicine AT haojingtang dedifferentiatedfatcellscurrentapplicationsandfuturedirectionsinregenerativemedicine AT jianli dedifferentiatedfatcellscurrentapplicationsandfuturedirectionsinregenerativemedicine AT junrongcai dedifferentiatedfatcellscurrentapplicationsandfuturedirectionsinregenerativemedicine AT yunjunliao dedifferentiatedfatcellscurrentapplicationsandfuturedirectionsinregenerativemedicine |