Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells
Zhijie Ding,1,* Marion Joy,1,* Marina V Kameneva,1-3 Partha Roy1,3-6 1Department of Bioengineering, 2Department of Surgery, 3McGowan Institute of Regenerative Medicine, 4Department of Pathology, 5Department of Cell Biology, 6Magee Women&rsquo...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-02-01
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| Series: | Breast Cancer: Targets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/nanomolar-concentration-of-blood-soluble-drag-reducing-polymer-inhibit-peer-reviewed-article-BCTT |
| _version_ | 1818858082069905408 |
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| author | Ding Z Joy M Kameneva MV Roy P |
| author_facet | Ding Z Joy M Kameneva MV Roy P |
| author_sort | Ding Z |
| collection | DOAJ |
| description | Zhijie Ding,1,* Marion Joy,1,* Marina V Kameneva,1-3 Partha Roy1,3-6 1Department of Bioengineering, 2Department of Surgery, 3McGowan Institute of Regenerative Medicine, 4Department of Pathology, 5Department of Cell Biology, 6Magee Women’s Research Institute, University of Pittsburgh, Pittsburgh, PA, USA *These authors contributed equally to this work Abstract: Metastasis is the leading cause of cancer mortality. Extravasation of cancer cells is a critical step of metastasis. We report a novel proof-of-concept study that investigated whether non-toxic blood-soluble chemical agents capable of rheological modification of the near-vessel-wall blood flow can reduce extravasation of tumor cells and subsequent development of metastasis. Using an experimental metastasis model, we demonstrated that systemic administration of nanomolar concentrations of so-called drag-reducing polymer dramatically impeded extravasation and development of pulmonary metastasis of breast cancer cells in mice. This is the first proof-of-principle study to directly demonstrate physical/rheological, as opposed to chemical, way to prevent cancer cells from extravasation and developing metastasis and, thus, it opens the possibility of a new direction of adjuvant interventional approach in cancer. Keywords: breast cancer, metastasis, extravasation, hemodynamics, drag-reducing polymer, blood cell traffic, microvessels |
| first_indexed | 2024-12-19T08:50:38Z |
| format | Article |
| id | doaj.art-094edc5f4c6146c1811dd2cee137131a |
| institution | Directory Open Access Journal |
| issn | 1179-1314 |
| language | English |
| last_indexed | 2024-12-19T08:50:38Z |
| publishDate | 2017-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Breast Cancer: Targets and Therapy |
| spelling | doaj.art-094edc5f4c6146c1811dd2cee137131a2022-12-21T20:28:44ZengDove Medical PressBreast Cancer: Targets and Therapy1179-13142017-02-01Volume 9616531544Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cellsDing ZJoy MKameneva MVRoy PZhijie Ding,1,* Marion Joy,1,* Marina V Kameneva,1-3 Partha Roy1,3-6 1Department of Bioengineering, 2Department of Surgery, 3McGowan Institute of Regenerative Medicine, 4Department of Pathology, 5Department of Cell Biology, 6Magee Women’s Research Institute, University of Pittsburgh, Pittsburgh, PA, USA *These authors contributed equally to this work Abstract: Metastasis is the leading cause of cancer mortality. Extravasation of cancer cells is a critical step of metastasis. We report a novel proof-of-concept study that investigated whether non-toxic blood-soluble chemical agents capable of rheological modification of the near-vessel-wall blood flow can reduce extravasation of tumor cells and subsequent development of metastasis. Using an experimental metastasis model, we demonstrated that systemic administration of nanomolar concentrations of so-called drag-reducing polymer dramatically impeded extravasation and development of pulmonary metastasis of breast cancer cells in mice. This is the first proof-of-principle study to directly demonstrate physical/rheological, as opposed to chemical, way to prevent cancer cells from extravasation and developing metastasis and, thus, it opens the possibility of a new direction of adjuvant interventional approach in cancer. Keywords: breast cancer, metastasis, extravasation, hemodynamics, drag-reducing polymer, blood cell traffic, microvesselshttps://www.dovepress.com/nanomolar-concentration-of-blood-soluble-drag-reducing-polymer-inhibit-peer-reviewed-article-BCTTBreast cancermetastasisextravasationhemodynamicsdrag reducing polymerblood cell traffic |
| spellingShingle | Ding Z Joy M Kameneva MV Roy P Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells Breast Cancer: Targets and Therapy Breast cancer metastasis extravasation hemodynamics drag reducing polymer blood cell traffic |
| title | Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells |
| title_full | Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells |
| title_fullStr | Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells |
| title_full_unstemmed | Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells |
| title_short | Nanomolar concentration of blood-soluble drag-reducing polymer inhibits experimental metastasis of human breast cancer cells |
| title_sort | nanomolar concentration of blood soluble drag reducing polymer inhibits experimental metastasis of human breast cancer cells |
| topic | Breast cancer metastasis extravasation hemodynamics drag reducing polymer blood cell traffic |
| url | https://www.dovepress.com/nanomolar-concentration-of-blood-soluble-drag-reducing-polymer-inhibit-peer-reviewed-article-BCTT |
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