High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls
Introduction: Vitamin D may affect the modulation of signaling pathways in the central nervous system. We aimed to evaluate the effect of high-dose vitamin D supplementation on neuropsychological functions in female adolescents. Methods: We studied the effects of 9 weeks of vitamin D supplementatio...
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Format: | Article |
Language: | English |
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Iran University of Medical Sciences
2021-05-01
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Series: | Basic and Clinical Neuroscience |
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Online Access: | http://bcn.iums.ac.ir/article-1-1538-en.html |
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author | Afsane Bahrami Fariborz Rezaeitalab Seyed Kazem Farahmand Zahra Mazloum Khorasani Seyed Mostafa Arabi Hamidreza Bahrami-Taghanaki Gordon A. Ferns Majid Ghayour-Mobarhan |
author_facet | Afsane Bahrami Fariborz Rezaeitalab Seyed Kazem Farahmand Zahra Mazloum Khorasani Seyed Mostafa Arabi Hamidreza Bahrami-Taghanaki Gordon A. Ferns Majid Ghayour-Mobarhan |
author_sort | Afsane Bahrami |
collection | DOAJ |
description | Introduction: Vitamin D may affect the modulation of signaling pathways in the central nervous system. We aimed to evaluate the effect of high-dose vitamin D supplementation on neuropsychological functions in female adolescents.
Methods: We studied the effects of 9 weeks of vitamin D supplementation (50000 IU vitamin D3 [cholecalciferol]/week) on cognitive abilities and sleep disorders in 940 adolescent girls.
Results: Oral vitamin D supplementation improved cognitive abilities, including memory, inhibitory control, selective attention, decision making, planning, sustained attention, and cognitive flexibility in healthy adolescent girls (P<0.001). The prevalence of subjects with insomnia after intervention fell from 15.0% to 11.3%. Similar results were also found for the prevalence of sleepiness (15.6% reduced to 14.7%), or cases with both insomnia and sleepiness (8.0% reduced to 6.1%; P<0.05).
Conclusion: High dose of vitamin D can improve cognitive abilities and alleviate insomnia and daytime sleepiness in adolescent girls. Further investigations are required on different population groups (age and gender) to determine the sustainability of these effects. The value of vitamin D therapy in other neurological disorders would also be of research interest. |
first_indexed | 2024-03-07T17:55:27Z |
format | Article |
id | doaj.art-09508f9bbca24b4db2bf2e463d08a165 |
institution | Directory Open Access Journal |
issn | 2008-126X 2228-7442 |
language | English |
last_indexed | 2024-03-07T17:55:27Z |
publishDate | 2021-05-01 |
publisher | Iran University of Medical Sciences |
record_format | Article |
series | Basic and Clinical Neuroscience |
spelling | doaj.art-09508f9bbca24b4db2bf2e463d08a1652024-03-02T12:15:58ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422021-05-01123339348High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent GirlsAfsane Bahrami0Fariborz Rezaeitalab1Seyed Kazem Farahmand2Zahra Mazloum Khorasani3Seyed Mostafa Arabi4Hamidreza Bahrami-Taghanaki5Gordon A. Ferns6Majid Ghayour-Mobarhan7 Cellular and Molecular Research Center, School of Medicine, Birjand University of Medical Sciences, Bijand, Iran. Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Traditional Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Endocrine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Chinese and Complementary Medicine Research Center, School of Traditional and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Division of Medical Education, School of Brighton & Sussex Medical, University of Brighton and the University of Sussex, Falmer, Brighton, Sussex, UK. Metabolic Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Introduction: Vitamin D may affect the modulation of signaling pathways in the central nervous system. We aimed to evaluate the effect of high-dose vitamin D supplementation on neuropsychological functions in female adolescents. Methods: We studied the effects of 9 weeks of vitamin D supplementation (50000 IU vitamin D3 [cholecalciferol]/week) on cognitive abilities and sleep disorders in 940 adolescent girls. Results: Oral vitamin D supplementation improved cognitive abilities, including memory, inhibitory control, selective attention, decision making, planning, sustained attention, and cognitive flexibility in healthy adolescent girls (P<0.001). The prevalence of subjects with insomnia after intervention fell from 15.0% to 11.3%. Similar results were also found for the prevalence of sleepiness (15.6% reduced to 14.7%), or cases with both insomnia and sleepiness (8.0% reduced to 6.1%; P<0.05). Conclusion: High dose of vitamin D can improve cognitive abilities and alleviate insomnia and daytime sleepiness in adolescent girls. Further investigations are required on different population groups (age and gender) to determine the sustainability of these effects. The value of vitamin D therapy in other neurological disorders would also be of research interest.http://bcn.iums.ac.ir/article-1-1538-en.htmlvitamin dcognitionadolescentssleepinessinsomnia |
spellingShingle | Afsane Bahrami Fariborz Rezaeitalab Seyed Kazem Farahmand Zahra Mazloum Khorasani Seyed Mostafa Arabi Hamidreza Bahrami-Taghanaki Gordon A. Ferns Majid Ghayour-Mobarhan High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls Basic and Clinical Neuroscience vitamin d cognition adolescents sleepiness insomnia |
title | High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls |
title_full | High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls |
title_fullStr | High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls |
title_full_unstemmed | High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls |
title_short | High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls |
title_sort | high dose vitamin d supplementation and improvement in cognitive abilities insomnia and daytime sleepiness in adolescent girls |
topic | vitamin d cognition adolescents sleepiness insomnia |
url | http://bcn.iums.ac.ir/article-1-1538-en.html |
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