Interleukin-1β regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability.

Interleukin-1β regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability.

The inflammasome has been recently implicated in obesity-associated dys-metabolism. However, of its products, the specific role of IL-1β was clinically demonstrated to mediate only the pancreatic beta-cell demise, and in mice mainly the intra-hepatic manifestations of obesity. Yet, it remains largel...

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Bibliographic Details
Main Authors: Ori Nov, Hagit Shapiro, Hilla Ovadia, Tanya Tarnovscki, Irit Dvir, Elad Shemesh, Julia Kovsan, Ilan Shelef, Yaron Carmi, Elena Voronov, Ron N Apte, Eli Lewis, Yulia Haim, Daniel Konrad, Nava Bashan, Assaf Rudich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23341960/pdf/?tool=EBI

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