Electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cell
Express determination of antibiotics is an extremely important task today. Portable electrochemical microdevices are a viable alternative to traditional methods of analysis. The development of such devices requires the study of redox processes in detail. This article is devoted to the comparative st...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
2022-08-01
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| Series: | Chimica Techno Acta |
| Subjects: | |
| Online Access: | https://journals.urfu.ru/index.php/chimtech/article/view/6074 |
| _version_ | 1797843820998557696 |
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| author | Tatiana S. Svalova Regina A. Zaidullina Margarita V. Medvedeva Elizaveta D. Vedernikova Alisa N. Kozitsina |
| author_facet | Tatiana S. Svalova Regina A. Zaidullina Margarita V. Medvedeva Elizaveta D. Vedernikova Alisa N. Kozitsina |
| author_sort | Tatiana S. Svalova |
| collection | DOAJ |
| description | Express determination of antibiotics is an extremely important task today. Portable electrochemical microdevices are a viable alternative to traditional methods of analysis. The development of such devices requires the study of redox processes in detail. This article is devoted to the comparative study of the electrochemical behavior of chloramphenicol in water solvents in standard laboratory and portable microelectrochemical cells. It was found that the electrochemical reduction of chloramphenicol proceeds via a 3-electron mechanism to the formation of a dimer. In the transition from the macrocell to the microcell, a decrease in the electrochemical reduction current and a shift of the peak potential to the cathode region are observed, which is apparently associated mainly with the type of the electrode material. The best characteristics of the direct electrochemical response were obtained in the differential pulse voltammetry mode. Under the selected operating parameters, the peak current of the electrochemical reduction of chloramphenicol is linearly dependent on the concentration of the antibiotic in the range of 2∙10–3–1∙10–5 M with a detection limit of 3∙10–5 M. Obtained characteristics are sufficient for the quality control of pharmaceuticals and can be improved through the use of organic and hybrid modifiers of the working electrode surface. |
| first_indexed | 2024-04-09T17:12:08Z |
| format | Article |
| id | doaj.art-09512c21607249babdaffca03ae8005a |
| institution | Directory Open Access Journal |
| issn | 2411-1414 |
| language | English |
| last_indexed | 2024-04-09T17:12:08Z |
| publishDate | 2022-08-01 |
| publisher | Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj.art-09512c21607249babdaffca03ae8005a2023-04-20T04:42:06ZengUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. ElʹcinaChimica Techno Acta2411-14142022-08-019410.15826/chimtech.2022.9.4.094537Electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cellTatiana S. Svalova0Regina A. Zaidullina1Margarita V. Medvedeva2Elizaveta D. Vedernikova3Alisa N. Kozitsina4Ural Federal UniversityUral Federal UniversityUral Federal UniversityUral Federal UniversityUral Federal UniversityExpress determination of antibiotics is an extremely important task today. Portable electrochemical microdevices are a viable alternative to traditional methods of analysis. The development of such devices requires the study of redox processes in detail. This article is devoted to the comparative study of the electrochemical behavior of chloramphenicol in water solvents in standard laboratory and portable microelectrochemical cells. It was found that the electrochemical reduction of chloramphenicol proceeds via a 3-electron mechanism to the formation of a dimer. In the transition from the macrocell to the microcell, a decrease in the electrochemical reduction current and a shift of the peak potential to the cathode region are observed, which is apparently associated mainly with the type of the electrode material. The best characteristics of the direct electrochemical response were obtained in the differential pulse voltammetry mode. Under the selected operating parameters, the peak current of the electrochemical reduction of chloramphenicol is linearly dependent on the concentration of the antibiotic in the range of 2∙10–3–1∙10–5 M with a detection limit of 3∙10–5 M. Obtained characteristics are sufficient for the quality control of pharmaceuticals and can be improved through the use of organic and hybrid modifiers of the working electrode surface.https://journals.urfu.ru/index.php/chimtech/article/view/6074chloramphenicolexpress-determinationelectrochemical behaviorvoltammetrymicrocellscreen-printed electrode |
| spellingShingle | Tatiana S. Svalova Regina A. Zaidullina Margarita V. Medvedeva Elizaveta D. Vedernikova Alisa N. Kozitsina Electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cell Chimica Techno Acta chloramphenicol express-determination electrochemical behavior voltammetry microcell screen-printed electrode |
| title | Electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cell |
| title_full | Electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cell |
| title_fullStr | Electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cell |
| title_full_unstemmed | Electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cell |
| title_short | Electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cell |
| title_sort | electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cell |
| topic | chloramphenicol express-determination electrochemical behavior voltammetry microcell screen-printed electrode |
| url | https://journals.urfu.ru/index.php/chimtech/article/view/6074 |
| work_keys_str_mv | AT tatianassvalova electrochemicalbehaviorofchloramphenicoloncarbonelectrodesinamicroelectrochemicalcell AT reginaazaidullina electrochemicalbehaviorofchloramphenicoloncarbonelectrodesinamicroelectrochemicalcell AT margaritavmedvedeva electrochemicalbehaviorofchloramphenicoloncarbonelectrodesinamicroelectrochemicalcell AT elizavetadvedernikova electrochemicalbehaviorofchloramphenicoloncarbonelectrodesinamicroelectrochemicalcell AT alisankozitsina electrochemicalbehaviorofchloramphenicoloncarbonelectrodesinamicroelectrochemicalcell |