Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review
Juvenile Idiopathic Arthritis (JIA) is currently the most common chronic rheumatic disease in children. It is known to have no single identity, but a variety of diagnoses. Under-diagnosis is a barrier to early treatment and reduced complications of the disease. Other immune-mediated diseases may coe...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/5/2803 |
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| author | Ignacio Ventura Gemma Clara Meira-Blanco María Ester Legidos-García Marcelino Pérez-Bermejo María Teresa Murillo-Llorente |
| author_facet | Ignacio Ventura Gemma Clara Meira-Blanco María Ester Legidos-García Marcelino Pérez-Bermejo María Teresa Murillo-Llorente |
| author_sort | Ignacio Ventura |
| collection | DOAJ |
| description | Juvenile Idiopathic Arthritis (JIA) is currently the most common chronic rheumatic disease in children. It is known to have no single identity, but a variety of diagnoses. Under-diagnosis is a barrier to early treatment and reduced complications of the disease. Other immune-mediated diseases may coexist in the same patient, making research in this area relevant. The main objective was to analyse whether links could be established between the molecular basis of JIA and other immune-mediated diseases. Early diagnosis may benefit patients with JIA, which in most cases goes undetected, leading to under-diagnosis, which can have a negative impact on children affected by the disease as they grow up. Methods: We performed a PRISMA systematic review focusing on immune molecules present in different autoimmune diseases. Results: A total of 13 papers from different countries dealing with the molecular basis of JIA and other immune diseases were evaluated and reviewed. Conclusions: Most of the autoimmune diseases analysed responded to the same group of drugs. Unfortunately, the reason for the under-diagnosis of these diseases remains unknown, as no evidence has been found to correlate the immunomolecular basis with the under-diagnosis of these immune-mediated diseases. The lack of information in this area means that further research is needed in order to provide a sound basis for preventing the development of immune-mediated diseases, especially in children, and to improve their quality of life through early diagnosis and treatment. |
| first_indexed | 2024-04-25T00:27:20Z |
| format | Article |
| id | doaj.art-0951abf78aa44b719ead09c7473b4787 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-25T00:27:20Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0951abf78aa44b719ead09c7473b47872024-03-12T16:46:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01255280310.3390/ijms25052803Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic ReviewIgnacio Ventura0Gemma Clara Meira-Blanco1María Ester Legidos-García2Marcelino Pérez-Bermejo3María Teresa Murillo-Llorente4Molecular and Mitochondrial Medicine Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo no. 2, 46001 Valencia, SpainSchool of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo no. 2, 46001 Valencia, SpainSONEV Research Group, Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo no. 2, 46001 Valencia, SpainSONEV Research Group, Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo no. 2, 46001 Valencia, SpainSONEV Research Group, Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo no. 2, 46001 Valencia, SpainJuvenile Idiopathic Arthritis (JIA) is currently the most common chronic rheumatic disease in children. It is known to have no single identity, but a variety of diagnoses. Under-diagnosis is a barrier to early treatment and reduced complications of the disease. Other immune-mediated diseases may coexist in the same patient, making research in this area relevant. The main objective was to analyse whether links could be established between the molecular basis of JIA and other immune-mediated diseases. Early diagnosis may benefit patients with JIA, which in most cases goes undetected, leading to under-diagnosis, which can have a negative impact on children affected by the disease as they grow up. Methods: We performed a PRISMA systematic review focusing on immune molecules present in different autoimmune diseases. Results: A total of 13 papers from different countries dealing with the molecular basis of JIA and other immune diseases were evaluated and reviewed. Conclusions: Most of the autoimmune diseases analysed responded to the same group of drugs. Unfortunately, the reason for the under-diagnosis of these diseases remains unknown, as no evidence has been found to correlate the immunomolecular basis with the under-diagnosis of these immune-mediated diseases. The lack of information in this area means that further research is needed in order to provide a sound basis for preventing the development of immune-mediated diseases, especially in children, and to improve their quality of life through early diagnosis and treatment.https://www.mdpi.com/1422-0067/25/5/2803anti-nuclear antibodiesantibioticsnon-bacterial osteomyelitiscyclooxygenasediabetes mellitushaploinsufficiency |
| spellingShingle | Ignacio Ventura Gemma Clara Meira-Blanco María Ester Legidos-García Marcelino Pérez-Bermejo María Teresa Murillo-Llorente Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review International Journal of Molecular Sciences anti-nuclear antibodies antibiotics non-bacterial osteomyelitis cyclooxygenase diabetes mellitus haploinsufficiency |
| title | Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review |
| title_full | Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review |
| title_fullStr | Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review |
| title_full_unstemmed | Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review |
| title_short | Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review |
| title_sort | is there a link between the molecular basis of juvenile idiopathic arthritis and autoimmune diseases systematic review |
| topic | anti-nuclear antibodies antibiotics non-bacterial osteomyelitis cyclooxygenase diabetes mellitus haploinsufficiency |
| url | https://www.mdpi.com/1422-0067/25/5/2803 |
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