Increased Exposure of Tacrolimus by Co-administered Mycophenolate Mofetil: Population Pharmacokinetic Analysis in Healthy Volunteers

Increased Exposure of Tacrolimus by Co-administered Mycophenolate Mofetil: Population Pharmacokinetic Analysis in Healthy Volunteers

Abstract The objective of the study was to investigate the pharmacokinetic drug-drug interactions between tacrolimus (TAC) and mycophenolate mofetil (MMF) in healthy Korean male volunteers. Seventeen volunteers participated in a three-period, single-dose, and fixed sequence study. They sequentially...

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Bibliographic Details
Main Authors: Jae Hyun Kim, Nayoung Han, Myeong Gyu Kim, Hwi-Yeol Yun, Sunhwa Lee, Eunjin Bae, Yon Su Kim, In-Wha Kim, Jung Mi Oh
Format: Article
Language:English
Published: Nature Portfolio 2018-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-20071-3

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