Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19
The COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an urgent need for novel therapeutic strategies to combat potentially fatal complications. Distinctive clinical features of severe COVID-19 include acute respiratory distress syndrome, neutrophilia, and cytokine sto...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/6/1383 |
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| author | Bhawna Tomar Hans-Joachim Anders Jyaysi Desai Shrikant R. Mulay |
| author_facet | Bhawna Tomar Hans-Joachim Anders Jyaysi Desai Shrikant R. Mulay |
| author_sort | Bhawna Tomar |
| collection | DOAJ |
| description | The COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an urgent need for novel therapeutic strategies to combat potentially fatal complications. Distinctive clinical features of severe COVID-19 include acute respiratory distress syndrome, neutrophilia, and cytokine storm, along with severe inflammatory response syndrome or sepsis. Here, we propose the putative role of enhanced neutrophil infiltration and the release of neutrophil extracellular traps, complement activation and vascular thrombosis during necroinflammation in COVID-19. Furthermore, we discuss how neutrophilic inflammation contributes to the higher mortality of COVID-19 in patients with underlying co-morbidities such as diabetes and cardiovascular diseases. This perspective highlights neutrophils as a putative target for the immunopathologic complications of severely ill COVID-19 patients. Development of the novel therapeutic strategies targeting neutrophils may help reduce the overall disease fatality rate of COVID-19. |
| first_indexed | 2024-03-10T19:25:21Z |
| format | Article |
| id | doaj.art-095400c681b54cfe983610f91752cd73 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:25:21Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-095400c681b54cfe983610f91752cd732023-11-20T02:37:00ZengMDPI AGCells2073-44092020-06-0196138310.3390/cells9061383Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19Bhawna Tomar0Hans-Joachim Anders1Jyaysi Desai2Shrikant R. Mulay3Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaDivision of Nephrology, Department of Medicine IV University Hospital LMU, 80336 Munich, GermanyDepartment of Rheumatology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDivision of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaThe COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an urgent need for novel therapeutic strategies to combat potentially fatal complications. Distinctive clinical features of severe COVID-19 include acute respiratory distress syndrome, neutrophilia, and cytokine storm, along with severe inflammatory response syndrome or sepsis. Here, we propose the putative role of enhanced neutrophil infiltration and the release of neutrophil extracellular traps, complement activation and vascular thrombosis during necroinflammation in COVID-19. Furthermore, we discuss how neutrophilic inflammation contributes to the higher mortality of COVID-19 in patients with underlying co-morbidities such as diabetes and cardiovascular diseases. This perspective highlights neutrophils as a putative target for the immunopathologic complications of severely ill COVID-19 patients. Development of the novel therapeutic strategies targeting neutrophils may help reduce the overall disease fatality rate of COVID-19.https://www.mdpi.com/2073-4409/9/6/1383SARS-CoV-2coronavirusneutrophilsNETscomplementthrombosis |
| spellingShingle | Bhawna Tomar Hans-Joachim Anders Jyaysi Desai Shrikant R. Mulay Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19 Cells SARS-CoV-2 coronavirus neutrophils NETs complement thrombosis |
| title | Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19 |
| title_full | Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19 |
| title_fullStr | Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19 |
| title_full_unstemmed | Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19 |
| title_short | Neutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19 |
| title_sort | neutrophils and neutrophil extracellular traps drive necroinflammation in covid 19 |
| topic | SARS-CoV-2 coronavirus neutrophils NETs complement thrombosis |
| url | https://www.mdpi.com/2073-4409/9/6/1383 |
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