Development and characterization of a copolymeric micelle containing soluble and insoluble model drugs.
<h4>Objectives</h4>Micelles are nano-sized particles with a core-shell structure that are made by natural or synthetic polymers or copolymers. The aim of this study was to develop and characterize a copolymeric micelle using two polymers loaded with hydrophilic and lipophilic drugs.<h...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0286251 |
| _version_ | 1797799804230696960 |
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| author | Farhad Mohammadi Alireza Moradi Fatemeh Tavakoli Samaneh Rahmati Rashin Giti Vahid Ramezani |
| author_facet | Farhad Mohammadi Alireza Moradi Fatemeh Tavakoli Samaneh Rahmati Rashin Giti Vahid Ramezani |
| author_sort | Farhad Mohammadi |
| collection | DOAJ |
| description | <h4>Objectives</h4>Micelles are nano-sized particles with a core-shell structure that are made by natural or synthetic polymers or copolymers. The aim of this study was to develop and characterize a copolymeric micelle using two polymers loaded with hydrophilic and lipophilic drugs.<h4>Methods</h4>Poly(ethylene glycol) and poly(ε-caprolactone) (PEG-PCL) were used to form a copolymeric micelle which was further loaded with either moxifloxacin or clarithromycin as hydrophilic and lipophilic drug samples, respectively. Characterization tests were done including fourier transform-infrared (FT-IR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, encapsulation efficiency, particle size, zeta potential, polydispersity index, transmission electron microscopy, and in-vitro release test.<h4>Results</h4>The construction of the copolymer was confirmed by the results of FT-IR and 1H NMR spectroscopy tests. The encapsulation efficiency test exhibited that loading was about 50% for twelve formulations. Particle size, zeta potential, polydispersity index, and transmission electron microscopy confirmed the formation of monodispersed, uniform, and nano-sized micelles with a few negative charges. The kinetic model of release was fitted to the Higuchi model.<h4>Conclusions</h4>Polymeric micelles consisting of PEG-PCL copolymer were loaded with adequate concentrations of hydrophilic (moxifloxacin) and lipophilic (clarithromycin) model drugs, with a mean particle size under 300 nm. Therefore, copolymeric micelles can be used as a suitable drug delivery system for mucous membranes and skin. |
| first_indexed | 2024-03-13T04:25:29Z |
| format | Article |
| id | doaj.art-0955285da97b4c829a8f25263be01dc6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-13T04:25:29Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0955285da97b4c829a8f25263be01dc62023-06-20T05:31:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01185e028625110.1371/journal.pone.0286251Development and characterization of a copolymeric micelle containing soluble and insoluble model drugs.Farhad MohammadiAlireza MoradiFatemeh TavakoliSamaneh RahmatiRashin GitiVahid Ramezani<h4>Objectives</h4>Micelles are nano-sized particles with a core-shell structure that are made by natural or synthetic polymers or copolymers. The aim of this study was to develop and characterize a copolymeric micelle using two polymers loaded with hydrophilic and lipophilic drugs.<h4>Methods</h4>Poly(ethylene glycol) and poly(ε-caprolactone) (PEG-PCL) were used to form a copolymeric micelle which was further loaded with either moxifloxacin or clarithromycin as hydrophilic and lipophilic drug samples, respectively. Characterization tests were done including fourier transform-infrared (FT-IR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, encapsulation efficiency, particle size, zeta potential, polydispersity index, transmission electron microscopy, and in-vitro release test.<h4>Results</h4>The construction of the copolymer was confirmed by the results of FT-IR and 1H NMR spectroscopy tests. The encapsulation efficiency test exhibited that loading was about 50% for twelve formulations. Particle size, zeta potential, polydispersity index, and transmission electron microscopy confirmed the formation of monodispersed, uniform, and nano-sized micelles with a few negative charges. The kinetic model of release was fitted to the Higuchi model.<h4>Conclusions</h4>Polymeric micelles consisting of PEG-PCL copolymer were loaded with adequate concentrations of hydrophilic (moxifloxacin) and lipophilic (clarithromycin) model drugs, with a mean particle size under 300 nm. Therefore, copolymeric micelles can be used as a suitable drug delivery system for mucous membranes and skin.https://doi.org/10.1371/journal.pone.0286251 |
| spellingShingle | Farhad Mohammadi Alireza Moradi Fatemeh Tavakoli Samaneh Rahmati Rashin Giti Vahid Ramezani Development and characterization of a copolymeric micelle containing soluble and insoluble model drugs. PLoS ONE |
| title | Development and characterization of a copolymeric micelle containing soluble and insoluble model drugs. |
| title_full | Development and characterization of a copolymeric micelle containing soluble and insoluble model drugs. |
| title_fullStr | Development and characterization of a copolymeric micelle containing soluble and insoluble model drugs. |
| title_full_unstemmed | Development and characterization of a copolymeric micelle containing soluble and insoluble model drugs. |
| title_short | Development and characterization of a copolymeric micelle containing soluble and insoluble model drugs. |
| title_sort | development and characterization of a copolymeric micelle containing soluble and insoluble model drugs |
| url | https://doi.org/10.1371/journal.pone.0286251 |
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