Histological characteristics of a giant cell tumor of the tendon sheaths associated with palmar fascial fibromatosis (case report)
Giant cell tumor of the tendon sheaths and palmar fascial fibromatosis are both fibrohistiocytic diseases. There is no information about their combination in the available literature. Aim To analyze the histological characteristics of a giant cell tumor of the tendon sheath associated with palmar...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics
2022-08-01
|
| Series: | Гений oртопедии |
| Subjects: |
| _version_ | 1811340770337095680 |
|---|---|
| author | Natalia A. Shchudlo Tatyana A. Stupina Nikolai S. Migalkin Tatyana N. Varsegova Irina V. Chirkova Daria A. Ostanina |
| author_facet | Natalia A. Shchudlo Tatyana A. Stupina Nikolai S. Migalkin Tatyana N. Varsegova Irina V. Chirkova Daria A. Ostanina |
| author_sort | Natalia A. Shchudlo |
| collection | DOAJ |
| description | Giant cell tumor of the tendon sheaths and palmar fascial fibromatosis are both fibrohistiocytic diseases. There is no information about their
combination in the available literature. Aim To analyze the histological characteristics of a giant cell tumor of the tendon sheath associated with
palmar fascial fibromatosis. Materials and methods Case history and pathomorphological examination of the surgical material of patient M with
recurrent palmar fascial fibromatosis and Dupuytren's contracture of the 5th ray of the right hand in grade 3 and a neoplasm of the 2nd finger of the
right hand Results A neoplasm with a thin fibrous capsule, permeated with blood vessels, many of them had abnormally thickened fibrous walls and
completely obliterated lumens. The cellular composition of the tumor is mixed: fibroblast-like cells, small histiocytes, siderophages, osteoclast-like
giant multinucleated cells, xanthoma and plasma cells. The frequency of mitoses is less than one per 10 fields of view, apoptotic bodies from zero to
several per field of view. In the composition of fibromatous cords in the projection of the V beam, giant multinucleated cells (possibly cells of foreign
bodies) were found. Conclusion For the first time, a clinical case of a giant cell tumor of the tendon sheaths, which developed against the background
of a long-term recurrent palmar fascial fibromatosis, is presented. Taking into account the pathomorphological characteristics of the surgical material,
the risk of its recurrence and malignancy in patient M. is low. However, the unpredictability of the histogenesis of this tumor known from the literature
is an indication for active clinical observation. |
| first_indexed | 2024-04-13T18:46:51Z |
| format | Article |
| id | doaj.art-09565f5744b746cc8dd0388a3275da2f |
| institution | Directory Open Access Journal |
| issn | 1028-4427 2542-131X |
| language | English |
| last_indexed | 2024-04-13T18:46:51Z |
| publishDate | 2022-08-01 |
| publisher | Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics |
| record_format | Article |
| series | Гений oртопедии |
| spelling | doaj.art-09565f5744b746cc8dd0388a3275da2f2022-12-22T02:34:34ZengRussian Ilizarov Scientific Center for Restorative Traumatology and OrthopaedicsГений oртопедии1028-44272542-131X2022-08-0128457958310.18019/1028-4427-2022-28-4-579-583Histological characteristics of a giant cell tumor of the tendon sheaths associated with palmar fascial fibromatosis (case report)Natalia A. Shchudlo0Tatyana A. Stupina1https://orcid.org/0000-0003-3434-0372Nikolai S. Migalkin2https://orcid.org/0000-0002-7502-5654Tatyana N. Varsegova3Irina V. Chirkova4Daria A. Ostanina5Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian FederationIlizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian FederationIlizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian FederationIlizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian FederationIlizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian FederationIlizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian FederationGiant cell tumor of the tendon sheaths and palmar fascial fibromatosis are both fibrohistiocytic diseases. There is no information about their combination in the available literature. Aim To analyze the histological characteristics of a giant cell tumor of the tendon sheath associated with palmar fascial fibromatosis. Materials and methods Case history and pathomorphological examination of the surgical material of patient M with recurrent palmar fascial fibromatosis and Dupuytren's contracture of the 5th ray of the right hand in grade 3 and a neoplasm of the 2nd finger of the right hand Results A neoplasm with a thin fibrous capsule, permeated with blood vessels, many of them had abnormally thickened fibrous walls and completely obliterated lumens. The cellular composition of the tumor is mixed: fibroblast-like cells, small histiocytes, siderophages, osteoclast-like giant multinucleated cells, xanthoma and plasma cells. The frequency of mitoses is less than one per 10 fields of view, apoptotic bodies from zero to several per field of view. In the composition of fibromatous cords in the projection of the V beam, giant multinucleated cells (possibly cells of foreign bodies) were found. Conclusion For the first time, a clinical case of a giant cell tumor of the tendon sheaths, which developed against the background of a long-term recurrent palmar fascial fibromatosis, is presented. Taking into account the pathomorphological characteristics of the surgical material, the risk of its recurrence and malignancy in patient M. is low. However, the unpredictability of the histogenesis of this tumor known from the literature is an indication for active clinical observation.palmar fascial fibromatosisdupuytren's contracturegiant cell tumor of the tendon sheathpathohistology |
| spellingShingle | Natalia A. Shchudlo Tatyana A. Stupina Nikolai S. Migalkin Tatyana N. Varsegova Irina V. Chirkova Daria A. Ostanina Histological characteristics of a giant cell tumor of the tendon sheaths associated with palmar fascial fibromatosis (case report) Гений oртопедии palmar fascial fibromatosis dupuytren's contracture giant cell tumor of the tendon sheath pathohistology |
| title | Histological characteristics of a giant cell tumor of the tendon sheaths associated with palmar fascial fibromatosis (case report) |
| title_full | Histological characteristics of a giant cell tumor of the tendon sheaths associated with palmar fascial fibromatosis (case report) |
| title_fullStr | Histological characteristics of a giant cell tumor of the tendon sheaths associated with palmar fascial fibromatosis (case report) |
| title_full_unstemmed | Histological characteristics of a giant cell tumor of the tendon sheaths associated with palmar fascial fibromatosis (case report) |
| title_short | Histological characteristics of a giant cell tumor of the tendon sheaths associated with palmar fascial fibromatosis (case report) |
| title_sort | histological characteristics of a giant cell tumor of the tendon sheaths associated with palmar fascial fibromatosis case report |
| topic | palmar fascial fibromatosis dupuytren's contracture giant cell tumor of the tendon sheath pathohistology |
| work_keys_str_mv | AT nataliaashchudlo histologicalcharacteristicsofagiantcelltumorofthetendonsheathsassociatedwithpalmarfascialfibromatosiscasereport AT tatyanaastupina histologicalcharacteristicsofagiantcelltumorofthetendonsheathsassociatedwithpalmarfascialfibromatosiscasereport AT nikolaismigalkin histologicalcharacteristicsofagiantcelltumorofthetendonsheathsassociatedwithpalmarfascialfibromatosiscasereport AT tatyananvarsegova histologicalcharacteristicsofagiantcelltumorofthetendonsheathsassociatedwithpalmarfascialfibromatosiscasereport AT irinavchirkova histologicalcharacteristicsofagiantcelltumorofthetendonsheathsassociatedwithpalmarfascialfibromatosiscasereport AT dariaaostanina histologicalcharacteristicsofagiantcelltumorofthetendonsheathsassociatedwithpalmarfascialfibromatosiscasereport |