Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats

Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats

Abstract Background Chronic high-fat diet (HFD) consumption caused not only obese-insulin resistance, but also cognitive decline and microglial hyperactivity. Modified gut microbiota by prebiotics and probiotics improved obese-insulin resistance. However, the effects of prebiotics, probiotics, and s...

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Bibliographic Details
Main Authors: Titikorn Chunchai, Wannipa Thunapong, Sakawdaurn Yasom, Keerati Wanchai, Sathima Eaimworawuthikul, Gabrielle Metzler, Anusorn Lungkaphin, Anchalee Pongchaidecha, Sasithorn Sirilun, Chaiyavat Chaiyasut, Wasana Pratchayasakul, Parameth Thiennimitr, Nipon Chattipakorn, Siriporn C. Chattipakorn
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Neuroinflammation
Subjects:
Xyloolidosaccharide
Lactobacillus paracasei HII01
Synbiotics
Microglia
Brain mitochondrial function
Cognitive function
Online Access:http://link.springer.com/article/10.1186/s12974-018-1055-2

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