Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant Rupture
Background: Autoimmune/inflammatory syndrome (ASIA) constitutes a set of related immune mediated diseases that share a common clinical picture and a history of a previous exposure to an adjuvant agent. From a clinical standpoint, patients present with none specific manifestations such as myalgia, ar...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kaviani Breast Disease Institute
2021-04-01
|
| Series: | Archives of Breast Cancer |
| Subjects: | |
| Online Access: | https://archbreastcancer.com/index.php/abc/article/view/361 |
| _version_ | 1819241818688061440 |
|---|---|
| author | Ivie Braga de Paula Erica Araujo Santiago |
| author_facet | Ivie Braga de Paula Erica Araujo Santiago |
| author_sort | Ivie Braga de Paula |
| collection | DOAJ |
| description | Background: Autoimmune/inflammatory syndrome (ASIA) constitutes a set of related immune mediated diseases that share a common clinical picture and a history of a previous exposure to an adjuvant agent. From a clinical standpoint, patients present with none specific manifestations such as myalgia, arthralgia, chronic fatigue and dry mouth as well as neurological manifestations such as cognitive disturbances, memory loss and neurologic disabilities. .
Case presentation: A previously healthy 25-year-old patient who underwent breast augmentation 3 years ago, with an asymptomatic rupture of the silicone breast implant, presented with three major criteria of ASIA, and improved after bilateral implant removal. She also had pleuritis and pericarditis, rarely described in such disease. A literature review on complications related to breast implants, their questionable relationship to the onset of autoimmune pathologies, and basic aspects of the diagnosis and management of ASIA was carried out.
Conclusion: The silicone presented in breast implants should be considered as an adjuvant, with the potential to cause chronic stimulation to the immune system. This can lead to systemic manifestations that can be severe in patients genetically predisposed and potentially not reversible even after surgical removal of the implants. When facing patients with breast implants and systemic clinical symptoms, lymph node disorders, neurological manifestations, or serositis as in the case presented, without other defined etiology, the possibility of ASIA should be considered in the differential diagnosis. |
| first_indexed | 2024-12-23T14:29:57Z |
| format | Article |
| id | doaj.art-09573b3062be4f9f984d2d96315bc13c |
| institution | Directory Open Access Journal |
| issn | 2383-0433 |
| language | English |
| last_indexed | 2024-12-23T14:29:57Z |
| publishDate | 2021-04-01 |
| publisher | Kaviani Breast Disease Institute |
| record_format | Article |
| series | Archives of Breast Cancer |
| spelling | doaj.art-09573b3062be4f9f984d2d96315bc13c2022-12-21T17:43:32ZengKaviani Breast Disease InstituteArchives of Breast Cancer2383-04332021-04-0110.32768/abc.202182156-161Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant RuptureIvie Braga de Paula0Erica Araujo Santiago1 Department of Radiology, Federal University of Minas Gerais, Orizonti Hospital, MG, BrazilDepartment of Radiology, Federal University of Minas Gerais, Felicio Rocho Hospital, MG, BrazilBackground: Autoimmune/inflammatory syndrome (ASIA) constitutes a set of related immune mediated diseases that share a common clinical picture and a history of a previous exposure to an adjuvant agent. From a clinical standpoint, patients present with none specific manifestations such as myalgia, arthralgia, chronic fatigue and dry mouth as well as neurological manifestations such as cognitive disturbances, memory loss and neurologic disabilities. . Case presentation: A previously healthy 25-year-old patient who underwent breast augmentation 3 years ago, with an asymptomatic rupture of the silicone breast implant, presented with three major criteria of ASIA, and improved after bilateral implant removal. She also had pleuritis and pericarditis, rarely described in such disease. A literature review on complications related to breast implants, their questionable relationship to the onset of autoimmune pathologies, and basic aspects of the diagnosis and management of ASIA was carried out. Conclusion: The silicone presented in breast implants should be considered as an adjuvant, with the potential to cause chronic stimulation to the immune system. This can lead to systemic manifestations that can be severe in patients genetically predisposed and potentially not reversible even after surgical removal of the implants. When facing patients with breast implants and systemic clinical symptoms, lymph node disorders, neurological manifestations, or serositis as in the case presented, without other defined etiology, the possibility of ASIA should be considered in the differential diagnosis.https://archbreastcancer.com/index.php/abc/article/view/361Autoimmune/inflammatory syndrome induced by adjuvants; ASIA; silicone breast implants; mammoplasty; complications related to silicone breast implants; pleuritis; pericarditis; breast implants and autoimmunity. |
| spellingShingle | Ivie Braga de Paula Erica Araujo Santiago Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant Rupture Archives of Breast Cancer Autoimmune/inflammatory syndrome induced by adjuvants; ASIA; silicone breast implants; mammoplasty; complications related to silicone breast implants; pleuritis; pericarditis; breast implants and autoimmunity. |
| title | Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant Rupture |
| title_full | Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant Rupture |
| title_fullStr | Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant Rupture |
| title_full_unstemmed | Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant Rupture |
| title_short | Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant Rupture |
| title_sort | autoimmune inflammatory syndrome induced by adjuvants asia syndrome associated with silicone breast implant rupture |
| topic | Autoimmune/inflammatory syndrome induced by adjuvants; ASIA; silicone breast implants; mammoplasty; complications related to silicone breast implants; pleuritis; pericarditis; breast implants and autoimmunity. |
| url | https://archbreastcancer.com/index.php/abc/article/view/361 |
| work_keys_str_mv | AT iviebragadepaula autoimmuneinflammatorysyndromeinducedbyadjuvantsasiasyndromeassociatedwithsiliconebreastimplantrupture AT ericaaraujosantiago autoimmuneinflammatorysyndromeinducedbyadjuvantsasiasyndromeassociatedwithsiliconebreastimplantrupture |