Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis
Objectives: To assess whether exposure to specific classes of neuroactive non-organochlorine insecticides is associated with diabetes mellitus or related metabolic traits. Methods: Eligibility criteria: Any type of epidemiological and human exposure studies providing an exposure contrast to neuroact...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018310973 |
| _version_ | 1818351411475251200 |
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| author | Martin Rune Hassan Hansen Erik Jørs Annelli Sandbæk Henrik Albert Kolstad Jörg Schullehner Vivi Schlünssen |
| author_facet | Martin Rune Hassan Hansen Erik Jørs Annelli Sandbæk Henrik Albert Kolstad Jörg Schullehner Vivi Schlünssen |
| author_sort | Martin Rune Hassan Hansen |
| collection | DOAJ |
| description | Objectives: To assess whether exposure to specific classes of neuroactive non-organochlorine insecticides is associated with diabetes mellitus or related metabolic traits. Methods: Eligibility criteria: Any type of epidemiological and human exposure studies providing an exposure contrast to neuroactive non-organochlorine insecticides and a measure of association to diabetes mellitus or related metabolic traits. We will include published peer-reviewed studies in both English and non-English language.Information sources: Articles will be located in the NCBI PubMed, Embase, Scopus, Web of Science and LILACS databases, supplemented with manual searching of reference lists and articles citing the included studies.Risk of bias assessment: Risk of bias in individual studies will be assessed using tools from the Navigation Guide systematic review methodology, while the risk of bias at the outcome level will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines.Data synthesis and analysis: When studies are sufficiently similar in population, exposure, comparator and effect estimate to meaningfully allow quantitative synthesis, we will perform meta-analysis. Otherwise, results will be summarized qualitatively. Funding: The authors are paid employees of their respective institutions. MRHH is a Ph.D. student working under grants from Aarhus University and the National Research Centre for the Working Environment. Registration: PROSPERO CRD42017068861. Keywords: Diabetes mellitus, Blood glucose, Hyperglycaemia, Pesticide, Insecticide |
| first_indexed | 2024-12-13T18:37:19Z |
| format | Article |
| id | doaj.art-0957442c3d524db49b816274658ba1f8 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-13T18:37:19Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-0957442c3d524db49b816274658ba1f82022-12-21T23:35:20ZengElsevierEnvironment International0160-41202019-06-01127664670Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysisMartin Rune Hassan Hansen0Erik Jørs1Annelli Sandbæk2Henrik Albert Kolstad3Jörg Schullehner4Vivi Schlünssen5Section for Environment, Work and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Bartholins Allé 2, Building 1260, DK-8000 Aarhus C, Denmark; National Research Centre for the Working Environment, Lersø Parkallé 105, DK-2100 København Ø, Denmark; Corresponding author at: Section for Environment, Work and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Bartholins Allé 2, Building 1260, DK-8000 Aarhus C, Denmark.Department of Occupational Medicine, Odense University Hospital, Kløvervænget 3, indgang 138, DK-5000 Odense C, DenmarkSection of General Practice, Department of Public Health, Aarhus University, Bartholins Allé 2, Building 1260, DK-8000 Aarhus C, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital and Central Denmark Region, Hedeager 3, DK-8200 Aarhus N, DenmarkDepartment of Occupational Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 35, indgang C, DK-8200 Aarhus N, DenmarkNational Centre for Register-based Research, Aarhus University, Fuglesangs Allé 4, Building K, DK-8210 Aarhus V, Denmark; Geological Survey of Denmark and Greenland, C. F. Møllers Allé 8, DK-8000 Aarhus C, DenmarkSection for Environment, Work and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Bartholins Allé 2, Building 1260, DK-8000 Aarhus C, Denmark; National Research Centre for the Working Environment, Lersø Parkallé 105, DK-2100 København Ø, DenmarkObjectives: To assess whether exposure to specific classes of neuroactive non-organochlorine insecticides is associated with diabetes mellitus or related metabolic traits. Methods: Eligibility criteria: Any type of epidemiological and human exposure studies providing an exposure contrast to neuroactive non-organochlorine insecticides and a measure of association to diabetes mellitus or related metabolic traits. We will include published peer-reviewed studies in both English and non-English language.Information sources: Articles will be located in the NCBI PubMed, Embase, Scopus, Web of Science and LILACS databases, supplemented with manual searching of reference lists and articles citing the included studies.Risk of bias assessment: Risk of bias in individual studies will be assessed using tools from the Navigation Guide systematic review methodology, while the risk of bias at the outcome level will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines.Data synthesis and analysis: When studies are sufficiently similar in population, exposure, comparator and effect estimate to meaningfully allow quantitative synthesis, we will perform meta-analysis. Otherwise, results will be summarized qualitatively. Funding: The authors are paid employees of their respective institutions. MRHH is a Ph.D. student working under grants from Aarhus University and the National Research Centre for the Working Environment. Registration: PROSPERO CRD42017068861. Keywords: Diabetes mellitus, Blood glucose, Hyperglycaemia, Pesticide, Insecticidehttp://www.sciencedirect.com/science/article/pii/S0160412018310973 |
| spellingShingle | Martin Rune Hassan Hansen Erik Jørs Annelli Sandbæk Henrik Albert Kolstad Jörg Schullehner Vivi Schlünssen Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis Environment International |
| title | Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis |
| title_full | Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis |
| title_fullStr | Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis |
| title_full_unstemmed | Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis |
| title_short | Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis |
| title_sort | exposure to neuroactive non organochlorine insecticides and diabetes mellitus and related metabolic disturbances protocol for a systematic review and meta analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0160412018310973 |
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