Maternal and Cord Blood Plasma sEng and TGF-β1 in Patients with Hypertensive Disorders of Pregnancy: A Pilot Study in a South Indian Population
Introduction: Hypertensive Disorders of Pregnancy (HDP) are one of the most widespread complications of pregnancy that affects both mother and foetus. It has been observed that in Preeclampsia, the release of soluble angiogenic factors from the ischemic placenta into maternal plasma plays a cruc...
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| Format: | Article |
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JCDR Research and Publications Private Limited
2017-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/9600/22790_CE[Ra]_F(Sh)_PF1(AH_RK)_PFA(P)_PF2(RB_SS).pdf |
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| author | Vickneshwaran Vinayagam Zachariah Bobby Syed Habeebullah Latha Chaturvedula Shruthi K Bharadwaj |
| author_facet | Vickneshwaran Vinayagam Zachariah Bobby Syed Habeebullah Latha Chaturvedula Shruthi K Bharadwaj |
| author_sort | Vickneshwaran Vinayagam |
| collection | DOAJ |
| description | Introduction: Hypertensive Disorders of Pregnancy (HDP) are
one of the most widespread complications of pregnancy that
affects both mother and foetus. It has been observed that in
Preeclampsia, the release of soluble angiogenic factors from
the ischemic placenta into maternal plasma plays a crucial role
in the pathogenesis.
Aim: To assess the plasma Soluble Endoglin (sEng) and
Transforming Growth Factor (TGF-β1) levels in various types
of HDP and to correlate the levels of these markers with the
pregnancy outcome.
Materials and Methods: A total of 128 pregnant women were
recruited and the study was carried out for a period of three
years. Cord blood and maternal blood plasma levels of sEng
and TGF-β1 were analysed by ELISA kits in Control Pregnant
Women (CPW), Gestational Hypertension (GH), Early Onset
Preeclampsia (EOPE), Late Onset Preeclampsia (LOPE), and
Eclampsia (E) during third trimester. The Gestational Age (GA)
at the time of delivery and Birth Weight (BW) of the baby also
were also evaluated.
Results: The circulating levels of maternal and cord blood sEng
were significantly higher in EOPE and E compared to CPW
and GH. However, the maternal and cord blood levels of TGFβ1 were significantly lower in LOPE and E when compared to
CPW and GH. The GA and BW of the baby were found to be
significantly lower in EOPE and E compared to CPW, GH and
LOPE. Also, a negative correlation was observed between
sEng levels with pregnancy outcome; GA and BW. And also, a
positive correlation was found between TGF-β1 and pregnancy
outcome.
Conclusion: A generalised angiogenic imbalance and poor
birth outcomes were observed in HDP. There is a spectrum
of biochemical derangements related to angiogenesis in GH,
EOPE, LOPE and E. |
| first_indexed | 2024-12-11T06:51:24Z |
| format | Article |
| id | doaj.art-09577fcf797045ed8d5d73c254aebc25 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T06:51:24Z |
| publishDate | 2017-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-09577fcf797045ed8d5d73c254aebc252022-12-22T01:16:53ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-03-01113QC32QC3410.7860/JCDR/2017/22790.9600Maternal and Cord Blood Plasma sEng and TGF-β1 in Patients with Hypertensive Disorders of Pregnancy: A Pilot Study in a South Indian PopulationVickneshwaran Vinayagam0Zachariah Bobby1Syed Habeebullah2Latha Chaturvedula3Shruthi K Bharadwaj4Ph D Scholar, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.Professor and Head, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.Professor, Department of Obstetrics and Gynaecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.Professor, Department of Obstetrics and Gynaecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.Student (DM Neonatology), Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.Introduction: Hypertensive Disorders of Pregnancy (HDP) are one of the most widespread complications of pregnancy that affects both mother and foetus. It has been observed that in Preeclampsia, the release of soluble angiogenic factors from the ischemic placenta into maternal plasma plays a crucial role in the pathogenesis. Aim: To assess the plasma Soluble Endoglin (sEng) and Transforming Growth Factor (TGF-β1) levels in various types of HDP and to correlate the levels of these markers with the pregnancy outcome. Materials and Methods: A total of 128 pregnant women were recruited and the study was carried out for a period of three years. Cord blood and maternal blood plasma levels of sEng and TGF-β1 were analysed by ELISA kits in Control Pregnant Women (CPW), Gestational Hypertension (GH), Early Onset Preeclampsia (EOPE), Late Onset Preeclampsia (LOPE), and Eclampsia (E) during third trimester. The Gestational Age (GA) at the time of delivery and Birth Weight (BW) of the baby also were also evaluated. Results: The circulating levels of maternal and cord blood sEng were significantly higher in EOPE and E compared to CPW and GH. However, the maternal and cord blood levels of TGFβ1 were significantly lower in LOPE and E when compared to CPW and GH. The GA and BW of the baby were found to be significantly lower in EOPE and E compared to CPW, GH and LOPE. Also, a negative correlation was observed between sEng levels with pregnancy outcome; GA and BW. And also, a positive correlation was found between TGF-β1 and pregnancy outcome. Conclusion: A generalised angiogenic imbalance and poor birth outcomes were observed in HDP. There is a spectrum of biochemical derangements related to angiogenesis in GH, EOPE, LOPE and E.https://jcdr.net/articles/PDF/9600/22790_CE[Ra]_F(Sh)_PF1(AH_RK)_PFA(P)_PF2(RB_SS).pdfangiogenic markerseclampsiapreeclampsia |
| spellingShingle | Vickneshwaran Vinayagam Zachariah Bobby Syed Habeebullah Latha Chaturvedula Shruthi K Bharadwaj Maternal and Cord Blood Plasma sEng and TGF-β1 in Patients with Hypertensive Disorders of Pregnancy: A Pilot Study in a South Indian Population Journal of Clinical and Diagnostic Research angiogenic markers eclampsia preeclampsia |
| title | Maternal and Cord Blood Plasma sEng and TGF-β1 in Patients with Hypertensive Disorders of Pregnancy: A Pilot Study in a South Indian Population |
| title_full | Maternal and Cord Blood Plasma sEng and TGF-β1 in Patients with Hypertensive Disorders of Pregnancy: A Pilot Study in a South Indian Population |
| title_fullStr | Maternal and Cord Blood Plasma sEng and TGF-β1 in Patients with Hypertensive Disorders of Pregnancy: A Pilot Study in a South Indian Population |
| title_full_unstemmed | Maternal and Cord Blood Plasma sEng and TGF-β1 in Patients with Hypertensive Disorders of Pregnancy: A Pilot Study in a South Indian Population |
| title_short | Maternal and Cord Blood Plasma sEng and TGF-β1 in Patients with Hypertensive Disorders of Pregnancy: A Pilot Study in a South Indian Population |
| title_sort | maternal and cord blood plasma seng and tgf β1 in patients with hypertensive disorders of pregnancy a pilot study in a south indian population |
| topic | angiogenic markers eclampsia preeclampsia |
| url | https://jcdr.net/articles/PDF/9600/22790_CE[Ra]_F(Sh)_PF1(AH_RK)_PFA(P)_PF2(RB_SS).pdf |
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