Relationship between trajectories of serum albumin levels and technique failure according to diabetic status in peritoneal dialysis patients: A joint modeling approach
Background: In peritoneal dialysis, technique failure is an important metric to be considered. This study was performed in order to identify the relationship between trajectories of serum albumin levels and peritoneal dialysis technique failure on end-stage renal disease patients according to diabet...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2017-06-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.23876/j.krcp.2017.36.2.182 |
| _version_ | 1818875903687524352 |
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| author | Mehri Khoshhali Iraj Kazemi S.Mohsen Hosseini Shiva Seirafian |
| author_facet | Mehri Khoshhali Iraj Kazemi S.Mohsen Hosseini Shiva Seirafian |
| author_sort | Mehri Khoshhali |
| collection | DOAJ |
| description | Background: In peritoneal dialysis, technique failure is an important metric to be considered. This study was performed in order to identify the relationship between trajectories of serum albumin levels and peritoneal dialysis technique failure on end-stage renal disease patients according to diabetic status. Furthermore, this study was performed to reveal predictors of serum albumin and technique failure simultaneously. Methods: This retrospective cohort study included 300 (189 non-diabetic and 111 diabetic) end-stage renal disease patients on continuous ambulatory peritoneal dialysis treated in Al-Zahra Hospital, Isfahan, Iran, from May 2005 to March 2015. Bayesian joint modeling was carried out in order to determine the relationship between trajectories of serum albumin levels and peritoneal dialysis technique failure in the patients according to diabetic status. Death from all causes was considered as a competing risk. Results: Using joint modeling approach, a relationship between trajectories of serum albumin with hazard of transfer to hemodialysis was estimated as −0.720 (95% confidence interval [CI], −0.971 to −0.472) for diabetic and −0.784 (95% CI, −0.963 to −0.587) for non-diabetic patients. From our findings it was showed that predictors of low serum albumin over time were time on peritoneal dialysis for diabetic patients and increase in age and time on peritoneal dialysis, history of previous hemodialysis, and lower body mass index in non-diabetic patients. Conclusion: The results of current study showed that controlling serum albumin over time in non-diabetic and diabetic patients undergoing continuous ambulatory peritoneal dialysis treatment can decrease risk of adverse outcomes during the peritoneal dialysis period. |
| first_indexed | 2024-12-19T13:33:54Z |
| format | Article |
| id | doaj.art-0959be5d84a14b52aad00a68a9e3a42d |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-19T13:33:54Z |
| publishDate | 2017-06-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-0959be5d84a14b52aad00a68a9e3a42d2022-12-21T20:19:17ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322017-06-0136218219110.23876/j.krcp.2017.36.2.182j.krcp.2017.36.2.182Relationship between trajectories of serum albumin levels and technique failure according to diabetic status in peritoneal dialysis patients: A joint modeling approachMehri Khoshhali0Iraj Kazemi1S.Mohsen Hosseini2Shiva Seirafian3Student Research Center, School of Health, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Statistics, University of Isfahan, Isfahan, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, IranDivision of Nephrology, Department of Medicine, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, IranBackground: In peritoneal dialysis, technique failure is an important metric to be considered. This study was performed in order to identify the relationship between trajectories of serum albumin levels and peritoneal dialysis technique failure on end-stage renal disease patients according to diabetic status. Furthermore, this study was performed to reveal predictors of serum albumin and technique failure simultaneously. Methods: This retrospective cohort study included 300 (189 non-diabetic and 111 diabetic) end-stage renal disease patients on continuous ambulatory peritoneal dialysis treated in Al-Zahra Hospital, Isfahan, Iran, from May 2005 to March 2015. Bayesian joint modeling was carried out in order to determine the relationship between trajectories of serum albumin levels and peritoneal dialysis technique failure in the patients according to diabetic status. Death from all causes was considered as a competing risk. Results: Using joint modeling approach, a relationship between trajectories of serum albumin with hazard of transfer to hemodialysis was estimated as −0.720 (95% confidence interval [CI], −0.971 to −0.472) for diabetic and −0.784 (95% CI, −0.963 to −0.587) for non-diabetic patients. From our findings it was showed that predictors of low serum albumin over time were time on peritoneal dialysis for diabetic patients and increase in age and time on peritoneal dialysis, history of previous hemodialysis, and lower body mass index in non-diabetic patients. Conclusion: The results of current study showed that controlling serum albumin over time in non-diabetic and diabetic patients undergoing continuous ambulatory peritoneal dialysis treatment can decrease risk of adverse outcomes during the peritoneal dialysis period.https://doi.org/10.23876/j.krcp.2017.36.2.182Joint modelingPeritoneal dialysisSerum albuminTechnique failure |
| spellingShingle | Mehri Khoshhali Iraj Kazemi S.Mohsen Hosseini Shiva Seirafian Relationship between trajectories of serum albumin levels and technique failure according to diabetic status in peritoneal dialysis patients: A joint modeling approach Kidney Research and Clinical Practice Joint modeling Peritoneal dialysis Serum albumin Technique failure |
| title | Relationship between trajectories of serum albumin levels and technique failure according to diabetic status in peritoneal dialysis patients: A joint modeling approach |
| title_full | Relationship between trajectories of serum albumin levels and technique failure according to diabetic status in peritoneal dialysis patients: A joint modeling approach |
| title_fullStr | Relationship between trajectories of serum albumin levels and technique failure according to diabetic status in peritoneal dialysis patients: A joint modeling approach |
| title_full_unstemmed | Relationship between trajectories of serum albumin levels and technique failure according to diabetic status in peritoneal dialysis patients: A joint modeling approach |
| title_short | Relationship between trajectories of serum albumin levels and technique failure according to diabetic status in peritoneal dialysis patients: A joint modeling approach |
| title_sort | relationship between trajectories of serum albumin levels and technique failure according to diabetic status in peritoneal dialysis patients a joint modeling approach |
| topic | Joint modeling Peritoneal dialysis Serum albumin Technique failure |
| url | https://doi.org/10.23876/j.krcp.2017.36.2.182 |
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