Sargachromenol Isolated from <i>Sargassum horneri</i> Attenuates Glutamate-Induced Neuronal Cell Death and Oxidative Stress through Inhibition of MAPK/NF-κB and Activation of Nrf2/HO-1 Signaling Pathway

Sargachromenol Isolated from <i>Sargassum horneri</i> Attenuates Glutamate-Induced Neuronal Cell Death and Oxidative Stress through Inhibition of MAPK/NF-κB and Activation of Nrf2/HO-1 Signaling Pathway

Oxidative stress-induced neuronal cell loss is considered to be the major mechanism underlying the pathogenesis of neurodegenerative diseases, which could be induced by a high concentration of glutamate. In this study, sargachromenol (SC) was isolated from a marine brown seaweed <i>Sargassum h...

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Bibliographic Details
Main Authors: Eui-Jeong Han, Chunying Zhang, Hyun-Soo Kim, Ji-Yul Kim, Sang-Muyn Park, Won-Kyo Jung, Ginnae Ahn, Seon-Heui Cha
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Marine Drugs
Subjects:
sargachromenol
<i>Sargassum horneri</i>
Neuroprotective effects
oxidative stress
neurons cell death
glutamate
Online Access:https://www.mdpi.com/1660-3397/20/11/710

Internet

https://www.mdpi.com/1660-3397/20/11/710

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