Analysis on the risk factors of second fracture in osteoporosis-
【Abstract】 Objective: To explore the clinical characteristics and risk factors of refracture in patients suffering from osteoporosis-related fractures as well as effective interventions. Methods: From January 2006 to January 2008, both out-patients and in-patients in our hospital who were over...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2011-04-01
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| Series: | Chinese Journal of Traumatology |
| Online Access: | http://www.cjtrauma.com/apps/ojs/index.php/cjt/article/view/61 |
| _version_ | 1818913103632400384 |
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| author | RUAN Wen-dong WANG Pei MA Xin-long GE Rui-ping ZHOU Xian-hu |
| author_facet | RUAN Wen-dong WANG Pei MA Xin-long GE Rui-ping ZHOU Xian-hu |
| author_sort | RUAN Wen-dong |
| collection | DOAJ |
| description | 【Abstract】 Objective: To explore the clinical characteristics
and risk factors of refracture in patients suffering
from osteoporosis-related fractures as well as effective
interventions.
Methods: From January 2006 to January 2008, both
out-patients and in-patients in our hospital who were over
50 years old and suffered from osteoporosis-related fractures
were selected for this research. They were divided
into fracture group and refracture group. The refracture rate
was followed up for 2 years, during which 11 patients developed
refracture, thus were included in the refracture group.
Therefore, 273 patients, 225 first-fracture cases, aged (67.7±
8.5) years, and 48 refracture cases, aged (72.7±9.5) years,
were included in this study. General data including age and
sex, fracture types, femoral neck bone mineral density (BMD)
T-scores tested by dual-energy X-rays absorptiometry
(DEXA), Charlson index, time-frame between two fractures
as well as mobility skill assessment were collected and analyzed
by single-factor and multivariate statistical methods.
Results: Females accounted for 70.2% of the fracture
group and 77.1% of the refracture group. The most common
refracture type was vertebral fracture for the first time and
femoral neck fracture for the second time during the followup.
The second fracture happened 3.7 years after the first
one on average. The refracture rate was 2.12% within one
year, and 4.66% within two years. Risk factors for a second
fracture in osteoporotic fracture patients included age (>75
years, HR=1.23, 95%CI 1.18-1.29; >85 years, HR=1.68, 95%
CI 1.60-1.76), female sex (HR=1.36, 95%CI 1.32-1.40), prior
vertebral fractures (HR=1.62, 95%CI 1.01-2.07), prior hip
fractures (HR=1.27, 95%CI 0.89-2.42), BMD T-score<-3.5
(HR=1.38, 95%CI 1.17-1.72) and weakened motor skills
(HR=1.27, 95%CI 1.09-1.40).
Conclusions: The risks of second fracture among
patients with initial brittle fracture are substantial. There is
adequate time between the first and second fractures for
interventions to reduce the risks of refracture, especially for
the old women with a vertebral or hip fracture. Medication,
motor functional rehabilitation and fall-down prevention
training are helpful.
Key words: Osteoporotic fractures; Recurrence; Risk
factors; Incidence |
| first_indexed | 2024-12-19T23:25:10Z |
| format | Article |
| id | doaj.art-095e5867051c4952add476d43f4f9c80 |
| institution | Directory Open Access Journal |
| issn | 1008-1275 |
| language | English |
| last_indexed | 2024-12-19T23:25:10Z |
| publishDate | 2011-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chinese Journal of Traumatology |
| spelling | doaj.art-095e5867051c4952add476d43f4f9c802022-12-21T20:01:52ZengElsevierChinese Journal of Traumatology1008-12752011-04-01142747843Analysis on the risk factors of second fracture in osteoporosis-RUAN Wen-dongWANG PeiMA Xin-longGE Rui-pingZHOU Xian-hu【Abstract】 Objective: To explore the clinical characteristics and risk factors of refracture in patients suffering from osteoporosis-related fractures as well as effective interventions. Methods: From January 2006 to January 2008, both out-patients and in-patients in our hospital who were over 50 years old and suffered from osteoporosis-related fractures were selected for this research. They were divided into fracture group and refracture group. The refracture rate was followed up for 2 years, during which 11 patients developed refracture, thus were included in the refracture group. Therefore, 273 patients, 225 first-fracture cases, aged (67.7± 8.5) years, and 48 refracture cases, aged (72.7±9.5) years, were included in this study. General data including age and sex, fracture types, femoral neck bone mineral density (BMD) T-scores tested by dual-energy X-rays absorptiometry (DEXA), Charlson index, time-frame between two fractures as well as mobility skill assessment were collected and analyzed by single-factor and multivariate statistical methods. Results: Females accounted for 70.2% of the fracture group and 77.1% of the refracture group. The most common refracture type was vertebral fracture for the first time and femoral neck fracture for the second time during the followup. The second fracture happened 3.7 years after the first one on average. The refracture rate was 2.12% within one year, and 4.66% within two years. Risk factors for a second fracture in osteoporotic fracture patients included age (>75 years, HR=1.23, 95%CI 1.18-1.29; >85 years, HR=1.68, 95% CI 1.60-1.76), female sex (HR=1.36, 95%CI 1.32-1.40), prior vertebral fractures (HR=1.62, 95%CI 1.01-2.07), prior hip fractures (HR=1.27, 95%CI 0.89-2.42), BMD T-score<-3.5 (HR=1.38, 95%CI 1.17-1.72) and weakened motor skills (HR=1.27, 95%CI 1.09-1.40). Conclusions: The risks of second fracture among patients with initial brittle fracture are substantial. There is adequate time between the first and second fractures for interventions to reduce the risks of refracture, especially for the old women with a vertebral or hip fracture. Medication, motor functional rehabilitation and fall-down prevention training are helpful. Key words: Osteoporotic fractures; Recurrence; Risk factors; Incidencehttp://www.cjtrauma.com/apps/ojs/index.php/cjt/article/view/61 |
| spellingShingle | RUAN Wen-dong WANG Pei MA Xin-long GE Rui-ping ZHOU Xian-hu Analysis on the risk factors of second fracture in osteoporosis- Chinese Journal of Traumatology |
| title | Analysis on the risk factors of second fracture in osteoporosis- |
| title_full | Analysis on the risk factors of second fracture in osteoporosis- |
| title_fullStr | Analysis on the risk factors of second fracture in osteoporosis- |
| title_full_unstemmed | Analysis on the risk factors of second fracture in osteoporosis- |
| title_short | Analysis on the risk factors of second fracture in osteoporosis- |
| title_sort | analysis on the risk factors of second fracture in osteoporosis |
| url | http://www.cjtrauma.com/apps/ojs/index.php/cjt/article/view/61 |
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