Thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess: a retrospective case series
BackgroundThrombocytopenia and poor prognosis in severe conditions are associated. However, the clinical significance of thrombocytopenia in pyogenic liver abscess (PLA) has not been evaluated.ObjectiveTo evaluate the association between thrombocytopenia and the prognosis of patients with PLA.Method...
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| Format: | Article |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1192523/full |
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| author | Sheng-zhong Li Shao-hua Liu Shao-hua Liu Meng Hao Tian Yu Tian Yu Song Hu Li Liu Li Liu Zhe-long Liu Zhe-long Liu |
| author_facet | Sheng-zhong Li Shao-hua Liu Shao-hua Liu Meng Hao Tian Yu Tian Yu Song Hu Li Liu Li Liu Zhe-long Liu Zhe-long Liu |
| author_sort | Sheng-zhong Li |
| collection | DOAJ |
| description | BackgroundThrombocytopenia and poor prognosis in severe conditions are associated. However, the clinical significance of thrombocytopenia in pyogenic liver abscess (PLA) has not been evaluated.ObjectiveTo evaluate the association between thrombocytopenia and the prognosis of patients with PLA.MethodsA consecutive case series of 458 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, China) between October 2011 and June 2021 was included in this cross-sectional analysis. Patient data were compared between the thrombocytopenia and non-thrombocytopenia groups. Multivariate logistic regression, receiver operating characteristic (ROC) curve and propensity score -matched analyses (PSM) were performed.ResultsOf the 458 patients with PLA, 94 (20.5%) developed thrombocytopenia, 19 (4.1%) developed septic shock, 14 (3.1%) were admitted to the ICU, and 15 (3.3%) died during hospitalization. Thrombocytopenia was independently associated with shock (95%CI = 3.529–57.944, P < 0.001), ICU admission (95%CI = 1.286–25.733, P = 0.022), and mortality (95%CI = 1.947–34.223, P = 0.004) in multivariate regression analysis. ROC analysis showed that thrombocytopenia may be an identified marker of shock [area under the ROC curve (AUC), 0.8119; cut-off, 92.50; P < 0.0001], ICU admission (AUC, 0.7484; cut-off, 82.50; P < 0.0015), and mortality (AUC, 0.7827; cut-off, 122.50; P < 0.002). These findings remained consistent across 86 pairs of patients analyzed for PSM analyses.ConclusionsThrombocytopenia is an independent risk factor for poor prognosis in PLA and patients may be more prone to adverse outcomes. |
| first_indexed | 2024-03-12T21:59:38Z |
| format | Article |
| id | doaj.art-095e81daa2c842b7bb0ca59b99294286 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-03-12T21:59:38Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-095e81daa2c842b7bb0ca59b992942862023-07-25T08:10:13ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-07-011010.3389/fsurg.2023.11925231192523Thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess: a retrospective case seriesSheng-zhong Li0Shao-hua Liu1Shao-hua Liu2Meng Hao3Tian Yu4Tian Yu5Song Hu6Li Liu7Li Liu8Zhe-long Liu9Zhe-long Liu10Department of Surgery, Wuhan Jinyintan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaDepartment of Gastroenterology, Zigui County People’s Hospital, Yichang, ChinaDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaDepartment of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Wuhan, ChinaBackgroundThrombocytopenia and poor prognosis in severe conditions are associated. However, the clinical significance of thrombocytopenia in pyogenic liver abscess (PLA) has not been evaluated.ObjectiveTo evaluate the association between thrombocytopenia and the prognosis of patients with PLA.MethodsA consecutive case series of 458 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, China) between October 2011 and June 2021 was included in this cross-sectional analysis. Patient data were compared between the thrombocytopenia and non-thrombocytopenia groups. Multivariate logistic regression, receiver operating characteristic (ROC) curve and propensity score -matched analyses (PSM) were performed.ResultsOf the 458 patients with PLA, 94 (20.5%) developed thrombocytopenia, 19 (4.1%) developed septic shock, 14 (3.1%) were admitted to the ICU, and 15 (3.3%) died during hospitalization. Thrombocytopenia was independently associated with shock (95%CI = 3.529–57.944, P < 0.001), ICU admission (95%CI = 1.286–25.733, P = 0.022), and mortality (95%CI = 1.947–34.223, P = 0.004) in multivariate regression analysis. ROC analysis showed that thrombocytopenia may be an identified marker of shock [area under the ROC curve (AUC), 0.8119; cut-off, 92.50; P < 0.0001], ICU admission (AUC, 0.7484; cut-off, 82.50; P < 0.0015), and mortality (AUC, 0.7827; cut-off, 122.50; P < 0.002). These findings remained consistent across 86 pairs of patients analyzed for PSM analyses.ConclusionsThrombocytopenia is an independent risk factor for poor prognosis in PLA and patients may be more prone to adverse outcomes.https://www.frontiersin.org/articles/10.3389/fsurg.2023.1192523/fullpyogenic liver abscessthrombocytopeniaplatelet countprognosiscross-sectional analysis |
| spellingShingle | Sheng-zhong Li Shao-hua Liu Shao-hua Liu Meng Hao Tian Yu Tian Yu Song Hu Li Liu Li Liu Zhe-long Liu Zhe-long Liu Thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess: a retrospective case series Frontiers in Surgery pyogenic liver abscess thrombocytopenia platelet count prognosis cross-sectional analysis |
| title | Thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess: a retrospective case series |
| title_full | Thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess: a retrospective case series |
| title_fullStr | Thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess: a retrospective case series |
| title_full_unstemmed | Thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess: a retrospective case series |
| title_short | Thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess: a retrospective case series |
| title_sort | thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess a retrospective case series |
| topic | pyogenic liver abscess thrombocytopenia platelet count prognosis cross-sectional analysis |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1192523/full |
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