Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action.

Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action.

Increasing preclinical and clinical evidence underscores the strong and rapid antidepressant properties of the glutamate-modulating NMDA receptor antagonist ketamine. Targeting the glutamatergic system might thus provide a novel molecular strategy for antidepressant treatment. Since glutamate is the...

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Bibliographic Details
Main Authors: Milan Scheidegger, Martin Walter, Mick Lehmann, Coraline Metzger, Simone Grimm, Heinz Boeker, Peter Boesiger, Anke Henning, Erich Seifritz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3461985?pdf=render

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