Role of blood beta-hydroxybutyric acid estimation as a diagnostic marker of feline hepatic lipidosis
Feline hepatic lipidosis (FHL), characterised by an accumulation of triglycerides in the cytoplasm of hepatocytes, is a common and potentially fatal liver disorder in cats. Hepatic lipidosis in cats can develop due to any condition that will impair nutrient uptake and is often presented with non-spe...
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| Format: | Article |
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Director of Academics and Research, Kerala Veterinary and Animal Sciences University
2023-12-01
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| Series: | Journal of Veterinary and Animal Sciences |
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| Online Access: | https://jvas.in/public_html/upload/article_file/article_file_s6kl9t.pdf?t=s6kl9t |
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| author | K. Asha Saigal O. K. Sindhu N. Madhavan Unny P. Vinu David Hamza Palekkodan P. Biju Habeeb |
| author_facet | K. Asha Saigal O. K. Sindhu N. Madhavan Unny P. Vinu David Hamza Palekkodan P. Biju Habeeb |
| author_sort | K. Asha Saigal |
| collection | DOAJ |
| description | Feline hepatic lipidosis (FHL), characterised by an accumulation of triglycerides in the cytoplasm of hepatocytes, is a common and potentially fatal liver disorder in cats. Hepatic lipidosis in cats can develop due to any condition that will impair nutrient uptake and is often presented with non-specific clinical signs. The present study describes the diagnosis of FHL based on clinicobiochemical, ultrasonographic, and cytological changes and evaluates the diagnostic utility of blood beta-hydroxybutyric acid (βHBA) estimation in FHL. Anorexia, weight loss, lethargy, vomiting, dehydration, and jaundice were the common clinical findings in cats with hepatic lipidosis. Serum biochemical evaluation revealed elevations in alkaline phosphatase (ALP), triglycerides, glucose, and total bilirubin. Ultrasonography revealed an enlarged hyperechoic liver. Fine-needle aspiration cytology of the liver revealed mild to severe vacuolation in the cytoplasm of hepatocytes. Blood beta-hydroxybutyric acid levels were found higher in cats with hepatic lipidosis than in healthy cats and cats with other hepatic disorders. Therefore, βHBA estimation, being a quick and non-invasive method, could be considered as a diagnostic marker in the early diagnosis of FHL. |
| first_indexed | 2024-03-08T14:30:41Z |
| format | Article |
| id | doaj.art-0964260c2e22465fbeb24a8fa2136ca2 |
| institution | Directory Open Access Journal |
| issn | 0971-0701 2582-0605 |
| language | English |
| last_indexed | 2024-03-08T14:30:41Z |
| publishDate | 2023-12-01 |
| publisher | Director of Academics and Research, Kerala Veterinary and Animal Sciences University |
| record_format | Article |
| series | Journal of Veterinary and Animal Sciences |
| spelling | doaj.art-0964260c2e22465fbeb24a8fa2136ca22024-01-12T11:02:35ZengDirector of Academics and Research, Kerala Veterinary and Animal Sciences UniversityJournal of Veterinary and Animal Sciences0971-07012582-06052023-12-0154497397910.51966/jvas.2023.54.4.973-979Role of blood beta-hydroxybutyric acid estimation as a diagnostic marker of feline hepatic lipidosisK. Asha Saigal0https://orcid.org/0009-0007-4558-7924O. K. Sindhu1https://orcid.org/0000-0002-1700-3449N. Madhavan Unny2P. Vinu David3Hamza Palekkodan4https://orcid.org/0000-0002-5278-0147P. Biju Habeeb5https://orcid.org/0000-0003-0046-1539MVSc Scholar, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Pookode, Lakkidi, Wayanad- 673576, Kerala Veterinary and Animal Sciences University, Kerala, IndiaAssistant Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Pookode, Lakkidi, Wayanad- 673576, Kerala Veterinary and Animal Sciences University, Kerala, IndiaProfessor and Head, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Pookode, Lakkidi, Wayanad- 673576, Kerala Veterinary and Animal Sciences University, Kerala, IndiaAssociate Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Pookode, Lakkidi, Wayanad- 673576, Kerala Veterinary and Animal Sciences University, Kerala, India Assistant Professor, Department of Veterinary Pathology, ollege of Veterinary and Animal Sciences, Pookode, Lakkidi, Wayanad- 673576, Kerala Veterinary and Animal Sciences University, Kerala, India Assistant Professor, Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, College of Veterinary and Animal Sciences, Pookode, Lakkidi, Wayanad- 673576, Kerala Veterinary and Animal Sciences University, Kerala, IndiaFeline hepatic lipidosis (FHL), characterised by an accumulation of triglycerides in the cytoplasm of hepatocytes, is a common and potentially fatal liver disorder in cats. Hepatic lipidosis in cats can develop due to any condition that will impair nutrient uptake and is often presented with non-specific clinical signs. The present study describes the diagnosis of FHL based on clinicobiochemical, ultrasonographic, and cytological changes and evaluates the diagnostic utility of blood beta-hydroxybutyric acid (βHBA) estimation in FHL. Anorexia, weight loss, lethargy, vomiting, dehydration, and jaundice were the common clinical findings in cats with hepatic lipidosis. Serum biochemical evaluation revealed elevations in alkaline phosphatase (ALP), triglycerides, glucose, and total bilirubin. Ultrasonography revealed an enlarged hyperechoic liver. Fine-needle aspiration cytology of the liver revealed mild to severe vacuolation in the cytoplasm of hepatocytes. Blood beta-hydroxybutyric acid levels were found higher in cats with hepatic lipidosis than in healthy cats and cats with other hepatic disorders. Therefore, βHBA estimation, being a quick and non-invasive method, could be considered as a diagnostic marker in the early diagnosis of FHL.https://jvas.in/public_html/upload/article_file/article_file_s6kl9t.pdf?t=s6kl9thepatic lipidosisbeta-hydroxybutyric acid (βhba)liver |
| spellingShingle | K. Asha Saigal O. K. Sindhu N. Madhavan Unny P. Vinu David Hamza Palekkodan P. Biju Habeeb Role of blood beta-hydroxybutyric acid estimation as a diagnostic marker of feline hepatic lipidosis Journal of Veterinary and Animal Sciences hepatic lipidosis beta-hydroxybutyric acid (βhba) liver |
| title | Role of blood beta-hydroxybutyric acid estimation as a diagnostic marker of feline hepatic lipidosis |
| title_full | Role of blood beta-hydroxybutyric acid estimation as a diagnostic marker of feline hepatic lipidosis |
| title_fullStr | Role of blood beta-hydroxybutyric acid estimation as a diagnostic marker of feline hepatic lipidosis |
| title_full_unstemmed | Role of blood beta-hydroxybutyric acid estimation as a diagnostic marker of feline hepatic lipidosis |
| title_short | Role of blood beta-hydroxybutyric acid estimation as a diagnostic marker of feline hepatic lipidosis |
| title_sort | role of blood beta hydroxybutyric acid estimation as a diagnostic marker of feline hepatic lipidosis |
| topic | hepatic lipidosis beta-hydroxybutyric acid (βhba) liver |
| url | https://jvas.in/public_html/upload/article_file/article_file_s6kl9t.pdf?t=s6kl9t |
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