Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and Sex
Children with cancer have a greater risk for vitamin D concerns because of compromised health before diagnosis, the disease itself, and treatments for the cancer. This IRB-approved retrospective, matched case–control study of children with and without cancer included three race categories: black, ot...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/10/2378 |
| _version_ | 1797501017772785664 |
|---|---|
| author | Michell Fullmer Annelise Su Steven Bachrach Jobayer Hossain Heidi H. Kecskemethy |
| author_facet | Michell Fullmer Annelise Su Steven Bachrach Jobayer Hossain Heidi H. Kecskemethy |
| author_sort | Michell Fullmer |
| collection | DOAJ |
| description | Children with cancer have a greater risk for vitamin D concerns because of compromised health before diagnosis, the disease itself, and treatments for the cancer. This IRB-approved retrospective, matched case–control study of children with and without cancer included three race categories: black, other, and Caucasian. This is the first study to directly compare serum 25-hydroxy vitamin D (25(OH)D) levels and status in newly diagnosed pediatric cancer patients with age-, sex-, and race-matched cancer-free children from the same geographic region of the US, all of whom are free from other conditions that negatively impact 25(OH)D levels. Univariable and multivariable ordinal logistic regressions were performed. In the 544 children (mean age of 8.5 years, 53% female), there were 136 newly diagnosed children with cancer and 408 matched non-cancer controls. Serum 25(OH)D levels at cancer diagnosis were lower (22.4 ng/mL) than in controls (30.1 ng/mL; <i>p</i> < 0.0001). Differences persisted across race (<i>p</i> < 0.001) and age (<i>p</i> < 0.001), but not sex. Older children exhibited lower 25(OH)D levels. Only 18.4% of the children with cancer had sufficient levels. Black children with cancer had the greatest rate of deficiency (39%). Race differences were evident: children of color (other and black) displayed higher levels of insufficiency; black children were most deficient. |
| first_indexed | 2024-03-10T03:12:13Z |
| format | Article |
| id | doaj.art-09646f80a006465aa81df051b5f0a580 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:12:13Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-09646f80a006465aa81df051b5f0a5802023-11-23T10:22:18ZengMDPI AGCancers2072-66942022-05-011410237810.3390/cancers14102378Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and SexMichell Fullmer0Annelise Su1Steven Bachrach2Jobayer Hossain3Heidi H. Kecskemethy4Nemours Center for Cancer and Blood Disorders, Nemours Children’s Health, Wilmington, DE 19803, USAUniversity of Richmond, Richmond, VA 23173, USADepartment of Pediatrics, Nemours Children’s Health, Wilmington, DE 19803, USANemours Biomedical Research, Nemours Children’s Health, Wilmington, DE 19803, USADepartment of Radiology, Nemours Children’s Health, Wilmington, DE 19803, USAChildren with cancer have a greater risk for vitamin D concerns because of compromised health before diagnosis, the disease itself, and treatments for the cancer. This IRB-approved retrospective, matched case–control study of children with and without cancer included three race categories: black, other, and Caucasian. This is the first study to directly compare serum 25-hydroxy vitamin D (25(OH)D) levels and status in newly diagnosed pediatric cancer patients with age-, sex-, and race-matched cancer-free children from the same geographic region of the US, all of whom are free from other conditions that negatively impact 25(OH)D levels. Univariable and multivariable ordinal logistic regressions were performed. In the 544 children (mean age of 8.5 years, 53% female), there were 136 newly diagnosed children with cancer and 408 matched non-cancer controls. Serum 25(OH)D levels at cancer diagnosis were lower (22.4 ng/mL) than in controls (30.1 ng/mL; <i>p</i> < 0.0001). Differences persisted across race (<i>p</i> < 0.001) and age (<i>p</i> < 0.001), but not sex. Older children exhibited lower 25(OH)D levels. Only 18.4% of the children with cancer had sufficient levels. Black children with cancer had the greatest rate of deficiency (39%). Race differences were evident: children of color (other and black) displayed higher levels of insufficiency; black children were most deficient.https://www.mdpi.com/2072-6694/14/10/237825(OH)Dcancerchilddeficiencydiagnosispediatrics |
| spellingShingle | Michell Fullmer Annelise Su Steven Bachrach Jobayer Hossain Heidi H. Kecskemethy Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and Sex Cancers 25(OH)D cancer child deficiency diagnosis pediatrics |
| title | Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and Sex |
| title_full | Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and Sex |
| title_fullStr | Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and Sex |
| title_full_unstemmed | Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and Sex |
| title_short | Newly Diagnosed Children with Cancer Have Lower 25-Vitamin D Levels than Their Cancer-Free Peers: A Comparison across Age, Race, and Sex |
| title_sort | newly diagnosed children with cancer have lower 25 vitamin d levels than their cancer free peers a comparison across age race and sex |
| topic | 25(OH)D cancer child deficiency diagnosis pediatrics |
| url | https://www.mdpi.com/2072-6694/14/10/2378 |
| work_keys_str_mv | AT michellfullmer newlydiagnosedchildrenwithcancerhavelower25vitamindlevelsthantheircancerfreepeersacomparisonacrossageraceandsex AT annelisesu newlydiagnosedchildrenwithcancerhavelower25vitamindlevelsthantheircancerfreepeersacomparisonacrossageraceandsex AT stevenbachrach newlydiagnosedchildrenwithcancerhavelower25vitamindlevelsthantheircancerfreepeersacomparisonacrossageraceandsex AT jobayerhossain newlydiagnosedchildrenwithcancerhavelower25vitamindlevelsthantheircancerfreepeersacomparisonacrossageraceandsex AT heidihkecskemethy newlydiagnosedchildrenwithcancerhavelower25vitamindlevelsthantheircancerfreepeersacomparisonacrossageraceandsex |