Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV
Among individuals coinfected with HCV and HIV, studies of mortality from non-hepatic causes have shown inconsistent results. The aim of this study was to investigate the contribution of HCV and HIV co-infection to mortality from hepatic and non-hepatic causes in Brazil. This retrospective cohort stu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867023000703 |
| _version_ | 1797657854803443712 |
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| author | Hélio Ranes de Menezes Filho Giuliano Grandi Ludimila Paula Vaz Cardoso Juan Felipe Galvão da Silva Soraia Mafra Machado Cesar de Almeida-Neto Ester Cerdeira Sabino Maria Cássia Mendes-Corrêa |
| author_facet | Hélio Ranes de Menezes Filho Giuliano Grandi Ludimila Paula Vaz Cardoso Juan Felipe Galvão da Silva Soraia Mafra Machado Cesar de Almeida-Neto Ester Cerdeira Sabino Maria Cássia Mendes-Corrêa |
| author_sort | Hélio Ranes de Menezes Filho |
| collection | DOAJ |
| description | Among individuals coinfected with HCV and HIV, studies of mortality from non-hepatic causes have shown inconsistent results. The aim of this study was to investigate the contribution of HCV and HIV co-infection to mortality from hepatic and non-hepatic causes in Brazil. This retrospective cohort study included blood donors from Fundação Pró-Sangue de São Paulo (FPS) who were followed from 1994 to 2016 to compare mortality and its causes between HIV-HCV coinfected individuals versus those seronegative for all tested infections. Records from the FPS database and the Mortality Information System were linked through a probabilistic record Relationship (RL). The Hazard Ratio (HR) was estimated using Cox multiple regression models. HCV-HIV coinfected individuals compared to seronegative individuals had a higher risk of death from all causes (HR = 14.54), non-liver neoplasms (HR = 2.55), infections (HR = 10.37) and liver disease (HR = 7.0). In addition, HCV mono-infected individuals compared to seronegative individuals had a higher risk of death from all causes (HR = 2.23), liver cancer (HR = 32.21), liver disease (HR = 14.92), infection (HR = 3.22), and trauma (HR = 1.68). Individuals coinfected with HCV and HIV have increased overall mortality and death due to infections, liver diseases and non-liver neoplasms as compared to those uninfected with HCV and HIV. |
| first_indexed | 2024-03-11T17:50:37Z |
| format | Article |
| id | doaj.art-096473163a94445aa054550d37ac1c62 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-03-11T17:50:37Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-096473163a94445aa054550d37ac1c622023-10-18T04:30:31ZengElsevierBrazilian Journal of Infectious Diseases1413-86702023-09-01275102810Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCVHélio Ranes de Menezes Filho0Giuliano Grandi1Ludimila Paula Vaz Cardoso2Juan Felipe Galvão da Silva3Soraia Mafra Machado4Cesar de Almeida-Neto5Ester Cerdeira Sabino6Maria Cássia Mendes-Corrêa7Department of Infectious Diseases, Universidade de São Paulo, School of Medicine, São Paulo, SP, Brazil; Department of Health Sciences, Universidade Federal de Jataí, GO, Brazil; Corresponding author.Medical School, Universidade Federal de São Paulo, São Paulo, SP, BrazilDepartment of Health Sciences, Universidade Federal de Jataí, GO, BrazilDepartment of Health Sciences, Universidade Federal de Jataí, GO, BrazilDepartment of Infectious Diseases, Universidade de São Paulo, School of Medicine, São Paulo, SP, BrazilHemocentro de São Paulo, Fundação Pró-Sangue, São Paulo, SP, BrazilDepartment of Infectious Diseases, Universidade de São Paulo, School of Medicine, São Paulo, SP, Brazil; Institute of Tropical Medicine, Universidade de São Paulo, São Paulo, SP, BrazilDepartment of Infectious Diseases, Universidade de São Paulo, School of Medicine, São Paulo, SP, Brazil; Institute of Tropical Medicine, Universidade de São Paulo, São Paulo, SP, BrazilAmong individuals coinfected with HCV and HIV, studies of mortality from non-hepatic causes have shown inconsistent results. The aim of this study was to investigate the contribution of HCV and HIV co-infection to mortality from hepatic and non-hepatic causes in Brazil. This retrospective cohort study included blood donors from Fundação Pró-Sangue de São Paulo (FPS) who were followed from 1994 to 2016 to compare mortality and its causes between HIV-HCV coinfected individuals versus those seronegative for all tested infections. Records from the FPS database and the Mortality Information System were linked through a probabilistic record Relationship (RL). The Hazard Ratio (HR) was estimated using Cox multiple regression models. HCV-HIV coinfected individuals compared to seronegative individuals had a higher risk of death from all causes (HR = 14.54), non-liver neoplasms (HR = 2.55), infections (HR = 10.37) and liver disease (HR = 7.0). In addition, HCV mono-infected individuals compared to seronegative individuals had a higher risk of death from all causes (HR = 2.23), liver cancer (HR = 32.21), liver disease (HR = 14.92), infection (HR = 3.22), and trauma (HR = 1.68). Individuals coinfected with HCV and HIV have increased overall mortality and death due to infections, liver diseases and non-liver neoplasms as compared to those uninfected with HCV and HIV.http://www.sciencedirect.com/science/article/pii/S1413867023000703Hepatitis CHIVMortality |
| spellingShingle | Hélio Ranes de Menezes Filho Giuliano Grandi Ludimila Paula Vaz Cardoso Juan Felipe Galvão da Silva Soraia Mafra Machado Cesar de Almeida-Neto Ester Cerdeira Sabino Maria Cássia Mendes-Corrêa Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV Brazilian Journal of Infectious Diseases Hepatitis C HIV Mortality |
| title | Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV |
| title_full | Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV |
| title_fullStr | Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV |
| title_full_unstemmed | Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV |
| title_short | Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV |
| title_sort | survival analysis over a 20 year period of a brazilian cohort of blood donors coinfected hiv hcv |
| topic | Hepatitis C HIV Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S1413867023000703 |
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