Estetrol: a new estrogen component in combined oral contraceptives: A review
Estetrol (E4) is a steroid hormone found in the urine of pregnant women in 1965. E4 is produced only during pregnancy and enters the maternal bloodstream through the placenta. Its concentration in maternal human plasma increases during pregnancy, reaching a maximum by the end of pregnancy (1 ng/mL)....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IP Berlin A.V.
2023-01-01
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| Series: | Гинекология |
| Subjects: | |
| Online Access: | https://gynecology.orscience.ru/2079-5831/article/viewFile/100485/pdf |
| _version_ | 1828056078459338752 |
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| author | Aida U. Hamadyanova Afzal H. Tuhtaboev Venera A. Shafieva Elena A. Kolodyazhnaya Julia R. Mansurova Aliya A. Muratova Arina A. Andreeva Julia A. Muzafarova |
| author_facet | Aida U. Hamadyanova Afzal H. Tuhtaboev Venera A. Shafieva Elena A. Kolodyazhnaya Julia R. Mansurova Aliya A. Muratova Arina A. Andreeva Julia A. Muzafarova |
| author_sort | Aida U. Hamadyanova |
| collection | DOAJ |
| description | Estetrol (E4) is a steroid hormone found in the urine of pregnant women in 1965. E4 is produced only during pregnancy and enters the maternal bloodstream through the placenta. Its concentration in maternal human plasma increases during pregnancy, reaching a maximum by the end of pregnancy (1 ng/mL). The pharmacological properties of E4 make it a promising agent for hormonal therapy and contraception. To date, phase II and III studies have shown promising results with the combination of 15 mg of E4 and 3 mg of drospirenone: this combined oral contraceptive has shown a good effect with a neutral metabolic effect. However, evidence is scarce about the effect of the new combination on the breast and bone tissue. Further studies are needed to consolidate the available data and to investigate possible side effects of prolonged use of E4-containing combined oral contraceptives compared to known ethinylestradiol and estradiol-containing combinations. |
| first_indexed | 2024-04-10T20:49:49Z |
| format | Article |
| id | doaj.art-09647bba9f244dbe90836a6d22983593 |
| institution | Directory Open Access Journal |
| issn | 2079-5696 2079-5831 |
| language | Russian |
| last_indexed | 2024-04-10T20:49:49Z |
| publishDate | 2023-01-01 |
| publisher | IP Berlin A.V. |
| record_format | Article |
| series | Гинекология |
| spelling | doaj.art-09647bba9f244dbe90836a6d229835932023-01-23T16:49:07ZrusIP Berlin A.V.Гинекология2079-56962079-58312023-01-0124645946410.26442/20795696.2022.6.20174979462Estetrol: a new estrogen component in combined oral contraceptives: A reviewAida U. Hamadyanova0https://orcid.org/0000-0001-6197-195XAfzal H. Tuhtaboev1https://orcid.org/0000-0002-3705-5692Venera A. Shafieva2https://orcid.org/0000-0001-9563-8856Elena A. Kolodyazhnaya3https://orcid.org/0000-0001-5133-7293Julia R. Mansurova4https://orcid.org/0000-0002-4503-8200Aliya A. Muratova5https://orcid.org/0000-0003-0875-0693Arina A. Andreeva6https://orcid.org/0000-0001-5572-1663Julia A. Muzafarova7https://orcid.org/0000-0001-9855-3022Bashkir State Medical UniversityBashkir State Medical UniversityBashkir State Medical UniversityBashkir State Medical UniversityBashkir State Medical UniversityBashkir State Medical UniversityBashkir State Medical UniversityBashkir State Medical UniversityEstetrol (E4) is a steroid hormone found in the urine of pregnant women in 1965. E4 is produced only during pregnancy and enters the maternal bloodstream through the placenta. Its concentration in maternal human plasma increases during pregnancy, reaching a maximum by the end of pregnancy (1 ng/mL). The pharmacological properties of E4 make it a promising agent for hormonal therapy and contraception. To date, phase II and III studies have shown promising results with the combination of 15 mg of E4 and 3 mg of drospirenone: this combined oral contraceptive has shown a good effect with a neutral metabolic effect. However, evidence is scarce about the effect of the new combination on the breast and bone tissue. Further studies are needed to consolidate the available data and to investigate possible side effects of prolonged use of E4-containing combined oral contraceptives compared to known ethinylestradiol and estradiol-containing combinations.https://gynecology.orscience.ru/2079-5831/article/viewFile/100485/pdfestetrolhormonal contraceptionestrogenhormonal therapy |
| spellingShingle | Aida U. Hamadyanova Afzal H. Tuhtaboev Venera A. Shafieva Elena A. Kolodyazhnaya Julia R. Mansurova Aliya A. Muratova Arina A. Andreeva Julia A. Muzafarova Estetrol: a new estrogen component in combined oral contraceptives: A review Гинекология estetrol hormonal contraception estrogen hormonal therapy |
| title | Estetrol: a new estrogen component in combined oral contraceptives: A review |
| title_full | Estetrol: a new estrogen component in combined oral contraceptives: A review |
| title_fullStr | Estetrol: a new estrogen component in combined oral contraceptives: A review |
| title_full_unstemmed | Estetrol: a new estrogen component in combined oral contraceptives: A review |
| title_short | Estetrol: a new estrogen component in combined oral contraceptives: A review |
| title_sort | estetrol a new estrogen component in combined oral contraceptives a review |
| topic | estetrol hormonal contraception estrogen hormonal therapy |
| url | https://gynecology.orscience.ru/2079-5831/article/viewFile/100485/pdf |
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