Association between inflammatory markers and non-alcoholic fatty liver disease in obese children
BackgroundGiven the high prevalence of non-alcoholic fatty liver disease (NAFLD) in obese children, non-invasive markers of disease to date are still limited and worth exploring.ObjectiveThis study aimed to evaluate the association between inflammatory markers and NAFLD in obese children.MethodsWe p...
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| Format: | Article |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.991393/full |
| _version_ | 1811213809212194816 |
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| author | Yamei Duan Jiayou Luo Xiongfeng Pan Jia Wei Xiang Xiao Jingya Li Miyang Luo |
| author_facet | Yamei Duan Jiayou Luo Xiongfeng Pan Jia Wei Xiang Xiao Jingya Li Miyang Luo |
| author_sort | Yamei Duan |
| collection | DOAJ |
| description | BackgroundGiven the high prevalence of non-alcoholic fatty liver disease (NAFLD) in obese children, non-invasive markers of disease to date are still limited and worth exploring.ObjectiveThis study aimed to evaluate the association between inflammatory markers and NAFLD in obese children.MethodsWe performed a case-control study in Hunan Children's Hospital from September 2020 to September 2021. Study participants were children with obesity diagnosed with NAFLD by abdominal ultrasound examination. Mean platelet volume (MPV), platelet distribution width (PDW), neutrophil, lymphocyte, monocyte, and platelet counts were extracted from medical records and inflammatory cytokines were measured by enzyme-linked immunosorbent assay (ELISA). Multivariable logistic regression analysis was performed to evaluate the association between inflammatory markers and NAFLD. We also used receiver operating characteristic curve analysis to assess the discriminative ability of inflammatory cytokines for NAFLD.ResultsTwo hundred and sixty-seven obese children were enrolled, including 176 NAFLD patients and 91 simple obesity controls. Multivariable logistic model indicated that increased interleukin (IL)-1β [odds ratio (OR) = 1.15, 95% confidence interval (CI): 1.04–1.27], IL-6 (OR = 1.28, 95% CI: 1.07–1.53), and IL-17 (OR = 1.04, 95% CI: 1.02–1.07) levels were significantly associated with NAFLD. In contrast, we observed non-significant associations for IL-8, IL-12, IL-21, IL-32, tumor necrosis factor-α (TNF-α), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), mean platelet volume (MPV), and platelet distribution width (PDW) with NAFLD. The area under the curves (AUCs) of IL-1β, IL-6, and IL-17 to discriminate obese children with or without NAFLD were 0.94, 0.94, and 0.97, respectively.ConclusionsOur results indicated that IL-1β, IL-6, and IL-17 levels were significantly associated with NAFLD. These inflammatory cytokines may serve as non-invasive markers to determine the development of NAFLD and potentially identify additional avenues for therapeutic intervention. |
| first_indexed | 2024-04-12T05:52:26Z |
| format | Article |
| id | doaj.art-09653c230220495abb0d1598867e5213 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-12T05:52:26Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-09653c230220495abb0d1598867e52132022-12-22T03:45:14ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-12-011010.3389/fpubh.2022.991393991393Association between inflammatory markers and non-alcoholic fatty liver disease in obese childrenYamei Duan0Jiayou Luo1Xiongfeng Pan2Jia Wei3Xiang Xiao4Jingya Li5Miyang Luo6Department of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, Hunan, ChinaDepartment of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, Hunan, ChinaDepartment of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, Hunan, ChinaDepartment of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, Hunan, ChinaDepartment of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, Hunan, ChinaDepartment of Maternal and Child Health, Xiangya School of Public Health, Central South University, Changsha, Hunan, ChinaDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, ChinaBackgroundGiven the high prevalence of non-alcoholic fatty liver disease (NAFLD) in obese children, non-invasive markers of disease to date are still limited and worth exploring.ObjectiveThis study aimed to evaluate the association between inflammatory markers and NAFLD in obese children.MethodsWe performed a case-control study in Hunan Children's Hospital from September 2020 to September 2021. Study participants were children with obesity diagnosed with NAFLD by abdominal ultrasound examination. Mean platelet volume (MPV), platelet distribution width (PDW), neutrophil, lymphocyte, monocyte, and platelet counts were extracted from medical records and inflammatory cytokines were measured by enzyme-linked immunosorbent assay (ELISA). Multivariable logistic regression analysis was performed to evaluate the association between inflammatory markers and NAFLD. We also used receiver operating characteristic curve analysis to assess the discriminative ability of inflammatory cytokines for NAFLD.ResultsTwo hundred and sixty-seven obese children were enrolled, including 176 NAFLD patients and 91 simple obesity controls. Multivariable logistic model indicated that increased interleukin (IL)-1β [odds ratio (OR) = 1.15, 95% confidence interval (CI): 1.04–1.27], IL-6 (OR = 1.28, 95% CI: 1.07–1.53), and IL-17 (OR = 1.04, 95% CI: 1.02–1.07) levels were significantly associated with NAFLD. In contrast, we observed non-significant associations for IL-8, IL-12, IL-21, IL-32, tumor necrosis factor-α (TNF-α), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), mean platelet volume (MPV), and platelet distribution width (PDW) with NAFLD. The area under the curves (AUCs) of IL-1β, IL-6, and IL-17 to discriminate obese children with or without NAFLD were 0.94, 0.94, and 0.97, respectively.ConclusionsOur results indicated that IL-1β, IL-6, and IL-17 levels were significantly associated with NAFLD. These inflammatory cytokines may serve as non-invasive markers to determine the development of NAFLD and potentially identify additional avenues for therapeutic intervention.https://www.frontiersin.org/articles/10.3389/fpubh.2022.991393/fullinflammatory markerscytokinesnon-alcoholic fatty liver diseaseassociationobesity children |
| spellingShingle | Yamei Duan Jiayou Luo Xiongfeng Pan Jia Wei Xiang Xiao Jingya Li Miyang Luo Association between inflammatory markers and non-alcoholic fatty liver disease in obese children Frontiers in Public Health inflammatory markers cytokines non-alcoholic fatty liver disease association obesity children |
| title | Association between inflammatory markers and non-alcoholic fatty liver disease in obese children |
| title_full | Association between inflammatory markers and non-alcoholic fatty liver disease in obese children |
| title_fullStr | Association between inflammatory markers and non-alcoholic fatty liver disease in obese children |
| title_full_unstemmed | Association between inflammatory markers and non-alcoholic fatty liver disease in obese children |
| title_short | Association between inflammatory markers and non-alcoholic fatty liver disease in obese children |
| title_sort | association between inflammatory markers and non alcoholic fatty liver disease in obese children |
| topic | inflammatory markers cytokines non-alcoholic fatty liver disease association obesity children |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.991393/full |
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