Compensatory Corneal Epithelial Changes After Femtolaser - Assisted Intracorneal Rings Implantation in Early and Moderate Cases of Keratoconus
Yasmine Maher Shaaban,1,2,* Tamer Abdelfattah Badran1,3,* 1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, 1181, Egypt; 2Ain Shams University Hospitals and Ain Shams Specialized Hospital, Cairo, 11588, Egypt; 3The Eye Subspeciality Center (ESC), Cairo,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-11-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/compensatory-corneal-epithelial-changes-after-femtolaser---assisted-in-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1797486268997697536 |
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| author | Shaaban YM Badran TA |
| author_facet | Shaaban YM Badran TA |
| author_sort | Shaaban YM |
| collection | DOAJ |
| description | Yasmine Maher Shaaban,1,2,* Tamer Abdelfattah Badran1,3,* 1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, 1181, Egypt; 2Ain Shams University Hospitals and Ain Shams Specialized Hospital, Cairo, 11588, Egypt; 3The Eye Subspeciality Center (ESC), Cairo, 11402, Egypt*These authors contributed equally to this workCorrespondence: Yasmine Maher Shaaban, Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, 1181, Egypt, Tel +20 1227123242, Fax +20224346753 ; +20224346041, Email yasminemaher0@gmail.comPurpose: To study the compensatory corneal epithelial changes after femtolaser-assisted intracorneal ring segment (ICRS) implantation in early and moderate cases of keratoconus (KC) using anterior segment optical coherence tomography (AS-OCT).Patients and Methods: A prospective observational non-randomized study of 40 eyes with mild to moderate KC received femtolaser-assisted ICRS implantation. Ferrara ICRS with different arc lengths and thicknesses were used according to the patients’ tomographic pattern. Patients had a clear central cornea, keratometry reading < 60 diopters, and corneal thickness > 400 microns. AS-OCT was performed preoperatively and at 1, 3, and 6 months after surgery. Corneal epithelial thickness (CET) was measured over 17 points (2 mm central and 16 points on 2– 5 mm and 5– 7 mm annular zones) over the pupil center. All data were collected and analyzed.Results: Comparing the preoperative and postoperative data, there was a statistically significant increase in the CET postoperatively throughout the 6-month follow-up period in all zones (p< 0.001). The epithelial thickness (ET) was noticed shortly around and central to the ring ridges by the first month (5– 7 mm zone). By the third month, the flattened central cornea (2 mm zone) and the 2– 5 mm zone showed a significant increase in ET up to the 6th month.Conclusion: ICRS implantation in KC results in a thicker and more regular epithelium in the central corneal zone as a secondary response to the corneal stromal changes induced by the implants.Keywords: keratoconus, Ferrara rings, epithelial thickness, AS-OCT |
| first_indexed | 2024-03-09T23:31:48Z |
| format | Article |
| id | doaj.art-0965df10f60e417d878460bf2b21a1ed |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-03-09T23:31:48Z |
| publishDate | 2023-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-0965df10f60e417d878460bf2b21a1ed2023-11-23T17:07:55ZengDove Medical PressClinical Ophthalmology1177-54832023-11-01Volume 173591359988396Compensatory Corneal Epithelial Changes After Femtolaser - Assisted Intracorneal Rings Implantation in Early and Moderate Cases of KeratoconusShaaban YMBadran TAYasmine Maher Shaaban,1,2,* Tamer Abdelfattah Badran1,3,* 1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, 1181, Egypt; 2Ain Shams University Hospitals and Ain Shams Specialized Hospital, Cairo, 11588, Egypt; 3The Eye Subspeciality Center (ESC), Cairo, 11402, Egypt*These authors contributed equally to this workCorrespondence: Yasmine Maher Shaaban, Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, 1181, Egypt, Tel +20 1227123242, Fax +20224346753 ; +20224346041, Email yasminemaher0@gmail.comPurpose: To study the compensatory corneal epithelial changes after femtolaser-assisted intracorneal ring segment (ICRS) implantation in early and moderate cases of keratoconus (KC) using anterior segment optical coherence tomography (AS-OCT).Patients and Methods: A prospective observational non-randomized study of 40 eyes with mild to moderate KC received femtolaser-assisted ICRS implantation. Ferrara ICRS with different arc lengths and thicknesses were used according to the patients’ tomographic pattern. Patients had a clear central cornea, keratometry reading < 60 diopters, and corneal thickness > 400 microns. AS-OCT was performed preoperatively and at 1, 3, and 6 months after surgery. Corneal epithelial thickness (CET) was measured over 17 points (2 mm central and 16 points on 2– 5 mm and 5– 7 mm annular zones) over the pupil center. All data were collected and analyzed.Results: Comparing the preoperative and postoperative data, there was a statistically significant increase in the CET postoperatively throughout the 6-month follow-up period in all zones (p< 0.001). The epithelial thickness (ET) was noticed shortly around and central to the ring ridges by the first month (5– 7 mm zone). By the third month, the flattened central cornea (2 mm zone) and the 2– 5 mm zone showed a significant increase in ET up to the 6th month.Conclusion: ICRS implantation in KC results in a thicker and more regular epithelium in the central corneal zone as a secondary response to the corneal stromal changes induced by the implants.Keywords: keratoconus, Ferrara rings, epithelial thickness, AS-OCThttps://www.dovepress.com/compensatory-corneal-epithelial-changes-after-femtolaser---assisted-in-peer-reviewed-fulltext-article-OPTHkeratoconusferrara ringsepithelial thicknessas-oct. |
| spellingShingle | Shaaban YM Badran TA Compensatory Corneal Epithelial Changes After Femtolaser - Assisted Intracorneal Rings Implantation in Early and Moderate Cases of Keratoconus Clinical Ophthalmology keratoconus ferrara rings epithelial thickness as-oct. |
| title | Compensatory Corneal Epithelial Changes After Femtolaser - Assisted Intracorneal Rings Implantation in Early and Moderate Cases of Keratoconus |
| title_full | Compensatory Corneal Epithelial Changes After Femtolaser - Assisted Intracorneal Rings Implantation in Early and Moderate Cases of Keratoconus |
| title_fullStr | Compensatory Corneal Epithelial Changes After Femtolaser - Assisted Intracorneal Rings Implantation in Early and Moderate Cases of Keratoconus |
| title_full_unstemmed | Compensatory Corneal Epithelial Changes After Femtolaser - Assisted Intracorneal Rings Implantation in Early and Moderate Cases of Keratoconus |
| title_short | Compensatory Corneal Epithelial Changes After Femtolaser - Assisted Intracorneal Rings Implantation in Early and Moderate Cases of Keratoconus |
| title_sort | compensatory corneal epithelial changes after femtolaser assisted intracorneal rings implantation in early and moderate cases of keratoconus |
| topic | keratoconus ferrara rings epithelial thickness as-oct. |
| url | https://www.dovepress.com/compensatory-corneal-epithelial-changes-after-femtolaser---assisted-in-peer-reviewed-fulltext-article-OPTH |
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