Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics
The World Health Organization has recently published a list of 12 drug-resistant bacteria that posed a significant threat to human health, and Pseudomonas aeruginosa (P. aeruginosa) was among them. In China, P. aeruginosa is a common pathogen in hospital acquired pneumonia, accounting for 16.9–22.0%...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1239540/full |
| _version_ | 1797692438636134400 |
|---|---|
| author | Xueqi Chen Shan Su Yan Yan Limei Yin Lihong Liu |
| author_facet | Xueqi Chen Shan Su Yan Yan Limei Yin Lihong Liu |
| author_sort | Xueqi Chen |
| collection | DOAJ |
| description | The World Health Organization has recently published a list of 12 drug-resistant bacteria that posed a significant threat to human health, and Pseudomonas aeruginosa (P. aeruginosa) was among them. In China, P. aeruginosa is a common pathogen in hospital acquired pneumonia, accounting for 16.9–22.0%. It is a ubiquitous opportunistic pathogen that can infect individuals with weakened immune systems, leading to hospital-acquired acute and systemic infections. The excessive use of antibiotics has led to the development of various mechanisms in P. aeruginosa to resist conventional drugs. Thus, there is an emergence of multidrug-resistant strains, posing a major challenge to conventional antibiotics and therapeutic approaches. Antimicrobial peptides are an integral component of host defense and have been found in many living organisms. Most antimicrobial peptides are characterized by negligible host toxicity and low resistance rates, making them become promising for use as antimicrobial products. This review particularly focuses on summarizing the inhibitory activity of natural antimicrobial peptides against P. aeruginosa planktonic cells and biofilms, as well as the drug interactions when these peptides used in combination with conventional antibiotics. Moreover, the underlying mechanism of these antimicrobial peptides against P. aeruginosa strains was mainly related to destroy the membrane structure through interacting with LPS or increasing ROS levels, or targeting cellular components, leaded to cell lysis. Hopefully, this analysis will provide valuable experimental data on developing novel compounds to combat P. aeruginosa. |
| first_indexed | 2024-03-12T02:28:37Z |
| format | Article |
| id | doaj.art-0967562b6fb340aa826a5d9bb5dece82 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-12T02:28:37Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-0967562b6fb340aa826a5d9bb5dece822023-09-05T10:28:41ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-09-011410.3389/fmicb.2023.12395401239540Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibioticsXueqi Chen0Shan Su1Yan Yan2Limei Yin3Lihong Liu4Department of Pharmacy, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Pharmacy, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaDepartment of Pharmacy, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Pharmacy, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Pharmacy, China-Japan Friendship Hospital, Beijing, ChinaThe World Health Organization has recently published a list of 12 drug-resistant bacteria that posed a significant threat to human health, and Pseudomonas aeruginosa (P. aeruginosa) was among them. In China, P. aeruginosa is a common pathogen in hospital acquired pneumonia, accounting for 16.9–22.0%. It is a ubiquitous opportunistic pathogen that can infect individuals with weakened immune systems, leading to hospital-acquired acute and systemic infections. The excessive use of antibiotics has led to the development of various mechanisms in P. aeruginosa to resist conventional drugs. Thus, there is an emergence of multidrug-resistant strains, posing a major challenge to conventional antibiotics and therapeutic approaches. Antimicrobial peptides are an integral component of host defense and have been found in many living organisms. Most antimicrobial peptides are characterized by negligible host toxicity and low resistance rates, making them become promising for use as antimicrobial products. This review particularly focuses on summarizing the inhibitory activity of natural antimicrobial peptides against P. aeruginosa planktonic cells and biofilms, as well as the drug interactions when these peptides used in combination with conventional antibiotics. Moreover, the underlying mechanism of these antimicrobial peptides against P. aeruginosa strains was mainly related to destroy the membrane structure through interacting with LPS or increasing ROS levels, or targeting cellular components, leaded to cell lysis. Hopefully, this analysis will provide valuable experimental data on developing novel compounds to combat P. aeruginosa.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1239540/fullantimicrobial peptidesPseudomonas aeruginosaEscherichia colidrug resistancebiofilmsinteraction |
| spellingShingle | Xueqi Chen Shan Su Yan Yan Limei Yin Lihong Liu Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics Frontiers in Microbiology antimicrobial peptides Pseudomonas aeruginosa Escherichia coli drug resistance biofilms interaction |
| title | Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics |
| title_full | Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics |
| title_fullStr | Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics |
| title_full_unstemmed | Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics |
| title_short | Anti-Pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics |
| title_sort | anti pseudomonas aeruginosa activity of natural antimicrobial peptides when used alone or in combination with antibiotics |
| topic | antimicrobial peptides Pseudomonas aeruginosa Escherichia coli drug resistance biofilms interaction |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1239540/full |
| work_keys_str_mv | AT xueqichen antipseudomonasaeruginosaactivityofnaturalantimicrobialpeptideswhenusedaloneorincombinationwithantibiotics AT shansu antipseudomonasaeruginosaactivityofnaturalantimicrobialpeptideswhenusedaloneorincombinationwithantibiotics AT yanyan antipseudomonasaeruginosaactivityofnaturalantimicrobialpeptideswhenusedaloneorincombinationwithantibiotics AT limeiyin antipseudomonasaeruginosaactivityofnaturalantimicrobialpeptideswhenusedaloneorincombinationwithantibiotics AT lihongliu antipseudomonasaeruginosaactivityofnaturalantimicrobialpeptideswhenusedaloneorincombinationwithantibiotics |