Risk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndrome
Abstract Background Malignant peritoneal mesothelioma (MPM) is a rare and highly aggressive tumor. Its clinical manifestations are diverse, and the symptoms are not specific. Some patients will develop paraneoplastic syndrome (PS) during the disease course. This study aims to analyze the risk factor...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-024-03312-w |
| _version_ | 1797276448872988672 |
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| author | Xin-Li Liang Yan-Dong Su Xin-Bao Li Yu-Bin Fu Ru Ma Rui Yang He-Liang Wu Yan Li |
| author_facet | Xin-Li Liang Yan-Dong Su Xin-Bao Li Yu-Bin Fu Ru Ma Rui Yang He-Liang Wu Yan Li |
| author_sort | Xin-Li Liang |
| collection | DOAJ |
| description | Abstract Background Malignant peritoneal mesothelioma (MPM) is a rare and highly aggressive tumor. Its clinical manifestations are diverse, and the symptoms are not specific. Some patients will develop paraneoplastic syndrome (PS) during the disease course. This study aims to analyze the risk factors of PS in patients with MPM and their impacts on prognosis. Methods The clinical data of MPM patients who underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) at our center from June 2015 to May 2023 were retrospectively analyzed. MPM patients were divided into PS group and non-PS group according to the diagnostic criteria. Univariate and multivariate analyses were performed to explore the risk factors of PS in MPM patients, and to analyze the impact of PS on prognosis. Results There were 146 MPM patients in this study, including 60 patients (41.1%) with PS and 86 patients (58.9%) without PS. The highest incidence of PS was thrombocytosis (33.6%), followed by neoplastic fever (9.6%). Univariate analysis revealed 8 factors (P < 0.05) with statistically significant differences between the two groups: prior surgical scores, targeted therapy history, Karnofsky performance status score, preoperative carbohydrate antigen (CA) 125 level, vascular tumor embolus, peritoneal cancer index, completeness of cytoreduction (CC) score and intraoperative ascites. Multivariate analysis identified 3 independent factors associated with PS: preoperative CA 125 level, vascular tumor embolus, and CC score. Survival analysis demonstrated that MPM patients with PS had worse prognosis, although PS was not an independent prognostic factor. Conclusions PS is not rare in patients with MPM, and is independently associated with preoperative CA 125 level, vascular tumor embolus and CC score. PS often indicates advanced disease and poor prognosis. |
| first_indexed | 2024-03-07T15:29:20Z |
| format | Article |
| id | doaj.art-09676f305c7b4138b9c9d2edef04b02a |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-07T15:29:20Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-09676f305c7b4138b9c9d2edef04b02a2024-03-05T16:31:46ZengBMCWorld Journal of Surgical Oncology1477-78192024-01-012211910.1186/s12957-024-03312-wRisk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndromeXin-Li Liang0Yan-Dong Su1Xin-Bao Li2Yu-Bin Fu3Ru Ma4Rui Yang5He-Liang Wu6Yan Li7Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Haidian DistrictDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Haidian DistrictDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Haidian DistrictDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Haidian DistrictDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Haidian DistrictDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Haidian DistrictDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Peking University Ninth School of Clinical MedicineDepartment of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Haidian DistrictAbstract Background Malignant peritoneal mesothelioma (MPM) is a rare and highly aggressive tumor. Its clinical manifestations are diverse, and the symptoms are not specific. Some patients will develop paraneoplastic syndrome (PS) during the disease course. This study aims to analyze the risk factors of PS in patients with MPM and their impacts on prognosis. Methods The clinical data of MPM patients who underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) at our center from June 2015 to May 2023 were retrospectively analyzed. MPM patients were divided into PS group and non-PS group according to the diagnostic criteria. Univariate and multivariate analyses were performed to explore the risk factors of PS in MPM patients, and to analyze the impact of PS on prognosis. Results There were 146 MPM patients in this study, including 60 patients (41.1%) with PS and 86 patients (58.9%) without PS. The highest incidence of PS was thrombocytosis (33.6%), followed by neoplastic fever (9.6%). Univariate analysis revealed 8 factors (P < 0.05) with statistically significant differences between the two groups: prior surgical scores, targeted therapy history, Karnofsky performance status score, preoperative carbohydrate antigen (CA) 125 level, vascular tumor embolus, peritoneal cancer index, completeness of cytoreduction (CC) score and intraoperative ascites. Multivariate analysis identified 3 independent factors associated with PS: preoperative CA 125 level, vascular tumor embolus, and CC score. Survival analysis demonstrated that MPM patients with PS had worse prognosis, although PS was not an independent prognostic factor. Conclusions PS is not rare in patients with MPM, and is independently associated with preoperative CA 125 level, vascular tumor embolus and CC score. PS often indicates advanced disease and poor prognosis.https://doi.org/10.1186/s12957-024-03312-wMalignant peritoneal mesotheliomaParaneoplastic syndromeThrombocytosisNeoplastic feverPrognosis |
| spellingShingle | Xin-Li Liang Yan-Dong Su Xin-Bao Li Yu-Bin Fu Ru Ma Rui Yang He-Liang Wu Yan Li Risk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndrome World Journal of Surgical Oncology Malignant peritoneal mesothelioma Paraneoplastic syndrome Thrombocytosis Neoplastic fever Prognosis |
| title | Risk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndrome |
| title_full | Risk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndrome |
| title_fullStr | Risk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndrome |
| title_full_unstemmed | Risk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndrome |
| title_short | Risk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndrome |
| title_sort | risk factors and prognosis of malignant peritoneal mesothelioma with paraneoplastic syndrome |
| topic | Malignant peritoneal mesothelioma Paraneoplastic syndrome Thrombocytosis Neoplastic fever Prognosis |
| url | https://doi.org/10.1186/s12957-024-03312-w |
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