Determination Of Micro Amount Of Spironolactone In Some Of Pharmaceutical Preparate By Using a Molecular Luminescence Technique.
The present study include a new developed method of analysis for determination of drug Spironolaction (SP) in some Pharmaceuticals by Spectrofluorometric method. Spironolaction was determined under optimal experimental condition that follows :- The excitation spectrum was (l=351 nm), the emmetion sp...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2008-03-01
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| Series: | Baghdad Science Journal |
| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/862 |
| _version_ | 1819208349915283456 |
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| author | Baghdad Science Journal |
| author_facet | Baghdad Science Journal |
| author_sort | Baghdad Science Journal |
| collection | DOAJ |
| description | The present study include a new developed method of analysis for determination of drug Spironolaction (SP) in some Pharmaceuticals by Spectrofluorometric method.
Spironolaction was determined under optimal experimental condition that follows :-
The excitation spectrum was (l=351 nm), the emmetion spectrum was (l=518 nm), pH=1, the suitable temperature for reaction 60oC and the optimal time less than (3) minute. The analysis and rang statistical data was:-Linear dynamic rang (1-10) ?g.ml-1, the detection limit (D.L = 0.023 ?g.ml-1), Molar absorptivity (? = 29875 liter mole-1 cm-1), Relative standard deviation (%RSD = 0.78), (%Erel = 3.3) and recovery (Rec = 96.6) percentage.
Determination of Spironolactone was accomplished by two methods
(A) Using direct calibration curve method, Corr. Coef. (R = 0.988 and %Rec = 97.4).
(B) Using standard additional methods Corr. Coef (R =0.988 and %Rec= 96.6). |
| first_indexed | 2024-12-23T05:37:59Z |
| format | Article |
| id | doaj.art-096771532c0c4e48b2edcf776a846eb0 |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-12-23T05:37:59Z |
| publishDate | 2008-03-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-096771532c0c4e48b2edcf776a846eb02022-12-21T17:58:15ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862008-03-015110.21123/bsj.5.1.55-62Determination Of Micro Amount Of Spironolactone In Some Of Pharmaceutical Preparate By Using a Molecular Luminescence Technique.Baghdad Science JournalThe present study include a new developed method of analysis for determination of drug Spironolaction (SP) in some Pharmaceuticals by Spectrofluorometric method. Spironolaction was determined under optimal experimental condition that follows :- The excitation spectrum was (l=351 nm), the emmetion spectrum was (l=518 nm), pH=1, the suitable temperature for reaction 60oC and the optimal time less than (3) minute. The analysis and rang statistical data was:-Linear dynamic rang (1-10) ?g.ml-1, the detection limit (D.L = 0.023 ?g.ml-1), Molar absorptivity (? = 29875 liter mole-1 cm-1), Relative standard deviation (%RSD = 0.78), (%Erel = 3.3) and recovery (Rec = 96.6) percentage. Determination of Spironolactone was accomplished by two methods (A) Using direct calibration curve method, Corr. Coef. (R = 0.988 and %Rec = 97.4). (B) Using standard additional methods Corr. Coef (R =0.988 and %Rec= 96.6).http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/862 |
| spellingShingle | Baghdad Science Journal Determination Of Micro Amount Of Spironolactone In Some Of Pharmaceutical Preparate By Using a Molecular Luminescence Technique. Baghdad Science Journal |
| title | Determination Of Micro Amount Of Spironolactone In Some Of Pharmaceutical Preparate By Using a Molecular Luminescence Technique. |
| title_full | Determination Of Micro Amount Of Spironolactone In Some Of Pharmaceutical Preparate By Using a Molecular Luminescence Technique. |
| title_fullStr | Determination Of Micro Amount Of Spironolactone In Some Of Pharmaceutical Preparate By Using a Molecular Luminescence Technique. |
| title_full_unstemmed | Determination Of Micro Amount Of Spironolactone In Some Of Pharmaceutical Preparate By Using a Molecular Luminescence Technique. |
| title_short | Determination Of Micro Amount Of Spironolactone In Some Of Pharmaceutical Preparate By Using a Molecular Luminescence Technique. |
| title_sort | determination of micro amount of spironolactone in some of pharmaceutical preparate by using a molecular luminescence technique |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/862 |
| work_keys_str_mv | AT baghdadsciencejournal determinationofmicroamountofspironolactoneinsomeofpharmaceuticalpreparatebyusingamolecularluminescencetechnique |