Association between metabolic syndrome and uric acid: a systematic review and meta-analysis
Abstract This systematic review and meta-analysis aim to provide the best evidence on the association between metabolic syndrome (MetS) and uric acid (UA) by determining the size of the effect of this biomarker on MetS. The review protocol is registered with PROSPERO (CRD42021231124). The search cov...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22025-2 |
| _version_ | 1811223289505251328 |
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| author | Elena Raya-Cano Manuel Vaquero-Abellán Rafael Molina-Luque Domingo De Pedro-Jiménez Guillermo Molina-Recio Manuel Romero-Saldaña |
| author_facet | Elena Raya-Cano Manuel Vaquero-Abellán Rafael Molina-Luque Domingo De Pedro-Jiménez Guillermo Molina-Recio Manuel Romero-Saldaña |
| author_sort | Elena Raya-Cano |
| collection | DOAJ |
| description | Abstract This systematic review and meta-analysis aim to provide the best evidence on the association between metabolic syndrome (MetS) and uric acid (UA) by determining the size of the effect of this biomarker on MetS. The review protocol is registered with PROSPERO (CRD42021231124). The search covered the PubMed and Scopus databases. Methodological quality was assessed with the STROBE tool, overall risk of bias with RevMan (Cochrane Collaboration) and quality of evidence with Grade Pro. Initially, 1582 articles were identified. Then, after excluding duplicates and reviewing titles and abstracts, 1529 articles were excluded from applying the eligibility criteria. We included 43 papers (56 groups) comparing UA concentrations between subjects 91,845 with MetS and 259,931 controls. Subjects with MetS had a higher mean UA of 0.57 mg/dl (95% CI 0.54–0.61) (p < 0.00001). Given the heterogeneity of the included studies, the researchers decided to perform subgroups analysis. Men with MetS have a higher UA concentration mg/dl 0.53 (95% CI 0.45–0.62, p < 0.00001) and women with MetS 0.57 (95% CI 0.48–0.66, p < 0.00001) compared to subjects without MetS. Assessment of UA concentration could provide a new avenue for early diagnosis of MetS, as a new biomarker and the possibility of new therapeutic targets. |
| first_indexed | 2024-04-12T08:30:25Z |
| format | Article |
| id | doaj.art-09698bfcfc4641da9783f5503402326b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T08:30:25Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-09698bfcfc4641da9783f5503402326b2022-12-22T03:40:13ZengNature PortfolioScientific Reports2045-23222022-11-0112111710.1038/s41598-022-22025-2Association between metabolic syndrome and uric acid: a systematic review and meta-analysisElena Raya-Cano0Manuel Vaquero-Abellán1Rafael Molina-Luque2Domingo De Pedro-Jiménez3Guillermo Molina-Recio4Manuel Romero-Saldaña5Department of Nursing, Pharmacology and Physiotherapy, University of CórdobaDepartment of Nursing, Pharmacology and Physiotherapy, University of CórdobaDepartment of Nursing, Pharmacology and Physiotherapy, University of CórdobaFaculty of Nursing, University of CádizDepartment of Nursing, Pharmacology and Physiotherapy, University of CórdobaDepartment of Nursing, Pharmacology and Physiotherapy, University of CórdobaAbstract This systematic review and meta-analysis aim to provide the best evidence on the association between metabolic syndrome (MetS) and uric acid (UA) by determining the size of the effect of this biomarker on MetS. The review protocol is registered with PROSPERO (CRD42021231124). The search covered the PubMed and Scopus databases. Methodological quality was assessed with the STROBE tool, overall risk of bias with RevMan (Cochrane Collaboration) and quality of evidence with Grade Pro. Initially, 1582 articles were identified. Then, after excluding duplicates and reviewing titles and abstracts, 1529 articles were excluded from applying the eligibility criteria. We included 43 papers (56 groups) comparing UA concentrations between subjects 91,845 with MetS and 259,931 controls. Subjects with MetS had a higher mean UA of 0.57 mg/dl (95% CI 0.54–0.61) (p < 0.00001). Given the heterogeneity of the included studies, the researchers decided to perform subgroups analysis. Men with MetS have a higher UA concentration mg/dl 0.53 (95% CI 0.45–0.62, p < 0.00001) and women with MetS 0.57 (95% CI 0.48–0.66, p < 0.00001) compared to subjects without MetS. Assessment of UA concentration could provide a new avenue for early diagnosis of MetS, as a new biomarker and the possibility of new therapeutic targets.https://doi.org/10.1038/s41598-022-22025-2 |
| spellingShingle | Elena Raya-Cano Manuel Vaquero-Abellán Rafael Molina-Luque Domingo De Pedro-Jiménez Guillermo Molina-Recio Manuel Romero-Saldaña Association between metabolic syndrome and uric acid: a systematic review and meta-analysis Scientific Reports |
| title | Association between metabolic syndrome and uric acid: a systematic review and meta-analysis |
| title_full | Association between metabolic syndrome and uric acid: a systematic review and meta-analysis |
| title_fullStr | Association between metabolic syndrome and uric acid: a systematic review and meta-analysis |
| title_full_unstemmed | Association between metabolic syndrome and uric acid: a systematic review and meta-analysis |
| title_short | Association between metabolic syndrome and uric acid: a systematic review and meta-analysis |
| title_sort | association between metabolic syndrome and uric acid a systematic review and meta analysis |
| url | https://doi.org/10.1038/s41598-022-22025-2 |
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