Transposable elements in TDP-43-mediated neurodegenerative disorders.
Elevated expression of specific transposable elements (TEs) has been observed in several neurodegenerative disorders. TEs also can be active during normal neurogenesis. By mining a series of deep sequencing datasets of protein-RNA interactions and of gene expression profiles, we uncovered extensive...
| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Makale |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Public Library of Science (PLoS)
2012-01-01
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| Seri Bilgileri: | PLoS ONE |
| Online Erişim: | http://europepmc.org/articles/PMC3434193?pdf=render |
| _version_ | 1828400447074861056 |
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| author | Wanhe Li Ying Jin Lisa Prazak Molly Hammell Josh Dubnau |
| author_facet | Wanhe Li Ying Jin Lisa Prazak Molly Hammell Josh Dubnau |
| author_sort | Wanhe Li |
| collection | DOAJ |
| description | Elevated expression of specific transposable elements (TEs) has been observed in several neurodegenerative disorders. TEs also can be active during normal neurogenesis. By mining a series of deep sequencing datasets of protein-RNA interactions and of gene expression profiles, we uncovered extensive binding of TE transcripts to TDP-43, an RNA-binding protein central to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Second, we find that association between TDP-43 and many of its TE targets is reduced in FTLD patients. Third, we discovered that a large fraction of the TEs to which TDP-43 binds become de-repressed in mouse TDP-43 disease models. We propose the hypothesis that TE mis-regulation contributes to TDP-43 related neurodegenerative diseases. |
| first_indexed | 2024-12-10T09:32:03Z |
| format | Article |
| id | doaj.art-096acfb6ec7c48adbac0a17b07df9b8f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T09:32:03Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-096acfb6ec7c48adbac0a17b07df9b8f2022-12-22T01:54:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4409910.1371/journal.pone.0044099Transposable elements in TDP-43-mediated neurodegenerative disorders.Wanhe LiYing JinLisa PrazakMolly HammellJosh DubnauElevated expression of specific transposable elements (TEs) has been observed in several neurodegenerative disorders. TEs also can be active during normal neurogenesis. By mining a series of deep sequencing datasets of protein-RNA interactions and of gene expression profiles, we uncovered extensive binding of TE transcripts to TDP-43, an RNA-binding protein central to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Second, we find that association between TDP-43 and many of its TE targets is reduced in FTLD patients. Third, we discovered that a large fraction of the TEs to which TDP-43 binds become de-repressed in mouse TDP-43 disease models. We propose the hypothesis that TE mis-regulation contributes to TDP-43 related neurodegenerative diseases.http://europepmc.org/articles/PMC3434193?pdf=render |
| spellingShingle | Wanhe Li Ying Jin Lisa Prazak Molly Hammell Josh Dubnau Transposable elements in TDP-43-mediated neurodegenerative disorders. PLoS ONE |
| title | Transposable elements in TDP-43-mediated neurodegenerative disorders. |
| title_full | Transposable elements in TDP-43-mediated neurodegenerative disorders. |
| title_fullStr | Transposable elements in TDP-43-mediated neurodegenerative disorders. |
| title_full_unstemmed | Transposable elements in TDP-43-mediated neurodegenerative disorders. |
| title_short | Transposable elements in TDP-43-mediated neurodegenerative disorders. |
| title_sort | transposable elements in tdp 43 mediated neurodegenerative disorders |
| url | http://europepmc.org/articles/PMC3434193?pdf=render |
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