Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters

Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters

A ruthenium-catalyzed asymmetric arylation of aliphatic aldehydes and α-ketoesters with arylboronic acids has been developed, giving chiral alkyl(aryl)methanols and α-hydroxy esters in good yields. The use of a chiral bidentate phosphoramidite ligand (Me-BIPAM) achieved excellent enantioselectivitie...

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Bibliographic Details
Main Authors: Momoko Watanabe, Kazunori Kurihara, Norio Miyaura, Yasunori Yamamoto, Tomohiko Shirai
Format: Article
Language:English
Published: MDPI AG 2011-06-01
Series:Molecules
Subjects:
asymmetric catalyst
bidentate phosphoramidite ligand
ruthenium catalyzed arylation
Online Access:http://www.mdpi.com/1420-3049/16/6/5020/

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