Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss
Hearing loss (HL) is one of the most common causes of disability, affecting 360 million people according to the World Health Organization (WHO). HL is most frequently of sensorineural origin, being caused by the irreversible loss of hair cells and/or spiral ganglion neurons. The etiology of sensorin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-04-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00107/full |
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| author | Isabel Varela-Nieto Isabel Varela-Nieto Isabel Varela-Nieto Teresa Partearroyo Néstor Vallecillo Néstor Vallecillo María A. Pajares María A. Pajares Gregorio Varela-Moreiras |
| author_facet | Isabel Varela-Nieto Isabel Varela-Nieto Isabel Varela-Nieto Teresa Partearroyo Néstor Vallecillo Néstor Vallecillo María A. Pajares María A. Pajares Gregorio Varela-Moreiras |
| author_sort | Isabel Varela-Nieto |
| collection | DOAJ |
| description | Hearing loss (HL) is one of the most common causes of disability, affecting 360 million people according to the World Health Organization (WHO). HL is most frequently of sensorineural origin, being caused by the irreversible loss of hair cells and/or spiral ganglion neurons. The etiology of sensorineural HL (SNHL) is multifactorial, with genetic and environmental factors such as noise, ototoxic substances and aging playing a role. The nutritional status is central in aging disability, but the interplay between nutrition and SNHL has only recently gained attention. Dietary supplementation could therefore constitute the first step for the prevention and potential repair of hearing damage before it reaches irreversibility. In this context, different epidemiological studies have shown correlations among the nutritional condition, increased total plasma homocysteine (tHcy) and SNHL. Several human genetic rare diseases are also associated with homocysteine (Hcy) metabolism and SNHL confirming this potential link. Accordingly, rodent experimental models have provided the molecular basis to understand the observed effects. Thus, increased tHcy levels and vitamin deficiencies, such as folic acid (FA), have been linked with SNHL, whereas long-term dietary supplementation with omega-3 fatty acids improved Hcy metabolism, cell survival and hearing acuity. Furthermore, pharmacological supplementations with the anti-oxidant fumaric acid that targets Hcy metabolism also improved SNHL. Overall these results strongly suggest that cochlear Hcy metabolism is a key player in the onset and progression of SNHL, opening the way for the design of prospective nutritional therapies. |
| first_indexed | 2024-12-13T09:46:58Z |
| format | Article |
| id | doaj.art-096b581d52b64138879d3d1d02d69eb4 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-13T09:46:58Z |
| publishDate | 2017-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-096b581d52b64138879d3d1d02d69eb42022-12-21T23:52:00ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992017-04-011010.3389/fnmol.2017.00107256310Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing LossIsabel Varela-Nieto0Isabel Varela-Nieto1Isabel Varela-Nieto2Teresa Partearroyo3Néstor Vallecillo4Néstor Vallecillo5María A. Pajares6María A. Pajares7Gregorio Varela-Moreiras8Departamento de Fisiopatología y del Sistema Nervios, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC-UAM)Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos IIIMadrid, SpainInvestigación en Otoneurocirugía, Instituto de Investigación Sanitaria La Paz (IdiPAZ)Madrid, SpainDepartamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU San PabloMadrid, SpainDepartamento de Fisiopatología y del Sistema Nervios, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC-UAM)Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos IIIMadrid, SpainDepartamento de Fisiopatología y del Sistema Nervios, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC-UAM)Madrid, SpainInvestigación en Otoneurocirugía, Instituto de Investigación Sanitaria La Paz (IdiPAZ)Madrid, SpainDepartamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU San PabloMadrid, SpainHearing loss (HL) is one of the most common causes of disability, affecting 360 million people according to the World Health Organization (WHO). HL is most frequently of sensorineural origin, being caused by the irreversible loss of hair cells and/or spiral ganglion neurons. The etiology of sensorineural HL (SNHL) is multifactorial, with genetic and environmental factors such as noise, ototoxic substances and aging playing a role. The nutritional status is central in aging disability, but the interplay between nutrition and SNHL has only recently gained attention. Dietary supplementation could therefore constitute the first step for the prevention and potential repair of hearing damage before it reaches irreversibility. In this context, different epidemiological studies have shown correlations among the nutritional condition, increased total plasma homocysteine (tHcy) and SNHL. Several human genetic rare diseases are also associated with homocysteine (Hcy) metabolism and SNHL confirming this potential link. Accordingly, rodent experimental models have provided the molecular basis to understand the observed effects. Thus, increased tHcy levels and vitamin deficiencies, such as folic acid (FA), have been linked with SNHL, whereas long-term dietary supplementation with omega-3 fatty acids improved Hcy metabolism, cell survival and hearing acuity. Furthermore, pharmacological supplementations with the anti-oxidant fumaric acid that targets Hcy metabolism also improved SNHL. Overall these results strongly suggest that cochlear Hcy metabolism is a key player in the onset and progression of SNHL, opening the way for the design of prospective nutritional therapies.http://journal.frontiersin.org/article/10.3389/fnmol.2017.00107/fullfolic acidomega-3nutritional imbalanceone-carbon metabolismoxidative stressrare diseases |
| spellingShingle | Isabel Varela-Nieto Isabel Varela-Nieto Isabel Varela-Nieto Teresa Partearroyo Néstor Vallecillo Néstor Vallecillo María A. Pajares María A. Pajares Gregorio Varela-Moreiras Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss Frontiers in Molecular Neuroscience folic acid omega-3 nutritional imbalance one-carbon metabolism oxidative stress rare diseases |
| title | Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss |
| title_full | Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss |
| title_fullStr | Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss |
| title_full_unstemmed | Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss |
| title_short | Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss |
| title_sort | cochlear homocysteine metabolism at the crossroad of nutrition and sensorineural hearing loss |
| topic | folic acid omega-3 nutritional imbalance one-carbon metabolism oxidative stress rare diseases |
| url | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00107/full |
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