Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease.

Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease.

Tauopathic pathways lead to degenerative changes in Alzheimer's disease and there is evidence that they are also involved in the neurodegenerative pathology of Parkinson's disease [PD]. We have examined tauopathic changes in striatum of the α-synuclein (α-Syn) A53T mutant mouse. Elevated l...

Full description

Bibliographic Details
Main Authors:	Jonathan Wills, Joel Credle, Thomas Haggerty, Jae-Hoon Lee, Adam W Oaks, Anita Sidhu
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-03-01
Series:	PLoS ONE
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21445308/?tool=EBI

Similar Items

Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease
by: Masliah Eliezer, et al.
Published: (2011-08-01)

α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease
by: Joel J. Credle, et al.
Published: (2015-04-01)

Synucleins antagonize endoplasmic reticulum function to modulate dopamine transporter trafficking.
by: Adam W Oaks, et al.
Published: (2013-01-01)

Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function.
by: Adam W Oaks, et al.
Published: (2013-01-01)

Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways.
by: Jonathan Wills, et al.
Published: (2012-01-01)

The Significance of Asymmetry in the Assessment of Brain Perfusion in Atypical Tauopathic Parkinsonian Syndromes
by: Piotr Alster, et al.
Published: (2022-07-01)

Ncx3-Induced Mitochondrial Dysfunction in Midbrain Leads to Neuroinflammation in Striatum of A53t-α-Synuclein Transgenic Old Mice
by: Rossana Di Martino, et al.
Published: (2021-07-01)

Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain
by: Santiago Rodriguez Ospina, et al.
Published: (2022-01-01)

Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson’s disease A53T mouse model
by: Alicia Flores-Cuadrado, et al.
Published: (2019-04-01)

Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration
by: Martin Regensburger, et al.
Published: (2020-11-01)

Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation
by: Huang Yue, et al.
Published: (2012-01-01)

Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.
by: Xi Chen, et al.
Published: (2015-01-01)

Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.
by: Valeriy Duka, et al.
Published: (2013-01-01)

Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein
by: Huan-Cheng Wu, et al.
Published: (2018-01-01)

Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson’s disease
by: Simone Bido, et al.
Published: (2017-08-01)

A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia
by: Martin Timo Henrich, et al.
Published: (2018-05-01)

Pre-fibrillar α-synuclein mutants cause Parkinson's disease-like non-motor symptoms in Drosophila.
by: Madhu Babu Gajula Balija, et al.
Published: (2011-01-01)

α-Synuclein and dopamine at the crossroads of Parkinson's disease.
by: Venda, L, et al.
Published: (2010)

The Role of α-Synuclein Oligomers in Parkinson’s Disease
by: Xiao-yu Du, et al.
Published: (2020-11-01)

Biomarkers and the Role of α-Synuclein in Parkinson’s Disease
by: Tingting Du, et al.
Published: (2021-03-01)

ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein
by: Nisha R. Dhanushkodi, et al.
Published: (2023-01-01)

E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease.
by: Ryusuke Sakai, et al.
Published: (2019-01-01)

α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls.
by: Lynnae M Smith, et al.
Published: (2012-01-01)

Environmental Enrichment Attenuates Oxidative Stress and Alters Detoxifying Enzymes in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease
by: Jung Hwa Seo, et al.
Published: (2020-09-01)

WT and A53T α-Synuclein Systems: Melting Diagram and Its New Interpretation
by: Mónika Bokor, et al.
Published: (2020-06-01)

Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner
by: An-Di Chen, et al.
Published: (2022-08-01)

Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice
by: Rubén Pavia-Collado, et al.
Published: (2021-03-01)

Initiation and progression of α-synuclein pathology in Parkinson’s disease
by: Tofaris, GK
Published: (2022)

ODE/PDE α-synuclein Models for Parkinson’s Disease /
by: Schiesser, William E., author 194177, et al.
Published: (2018)

The Convergence of Dopamine and α-Synuclein: Implications for Parkinson’s Disease
by: Danielle E Mor, et al.
Published: (2018-03-01)

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease
by: Jessika C. Bridi, et al.
Published: (2018-02-01)

Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2
by: Denglei Ma, et al.
Published: (2023-11-01)

Naturally occurring autoantibodies against α-synuclein rescues memory and motor deficits and attenuates α-synuclein pathology in mouse model of Parkinson's disease
by: Ya-ru Huang, et al.
Published: (2019-04-01)

Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys
by: Diana Alarcón-Arís, et al.
Published: (2020-09-01)

Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson’s disease mice
by: Mohammad Badr, et al.
Published: (2022-12-01)

The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease
by: Jessica K. Smith, et al.
Published: (2023-01-01)

Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease
by: Deqiang Han, et al.
Published: (2020-03-01)

Erythrocytic α-Synuclein as a potential biomarker for Parkinson’s disease
by: Chen Tian, et al.
Published: (2019-05-01)

Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?
by: Victorio M. Pozo Devoto, et al.
Published: (2017-09-01)

A Meta-Analysis of α-Synuclein Multiplication in Familial Parkinsonism
by: Adam Book, et al.
Published: (2018-12-01)