Tailoring nanoparticles for targeted drug delivery: From organ to subcellular level
Abstract An effective dose at specific sites is of paramount importance for disease therapy. While therapeutic reagents such as small molecule drugs, nucleic acids, peptides, and proteins are suffered from degradation or clearance by physiological environment, nanomedicine has emerged to improve dru...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-10-01
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| Series: | View |
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| Online Access: | https://doi.org/10.1002/VIW.20200131 |
| _version_ | 1818444191455248384 |
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| author | Tingxizi Liang Zejing Xing Liping Jiang Jun‐Jie Zhu |
| author_facet | Tingxizi Liang Zejing Xing Liping Jiang Jun‐Jie Zhu |
| author_sort | Tingxizi Liang |
| collection | DOAJ |
| description | Abstract An effective dose at specific sites is of paramount importance for disease therapy. While therapeutic reagents such as small molecule drugs, nucleic acids, peptides, and proteins are suffered from degradation or clearance by physiological environment, nanomedicine has emerged to improve drug delivery efficiency due to their superior targeting ability. By tailoring the properties of nanoparticle, including size, shape, surface chemistry, site‐specific drug delivery in organ, cellular, and subcellular level could be achieved. This minireview highlights recent advances in the development of targeted drug delivery system for disease therapy. |
| first_indexed | 2024-12-14T19:12:01Z |
| format | Article |
| id | doaj.art-096e4c5d43114709bba0124f5bf3d98a |
| institution | Directory Open Access Journal |
| issn | 2688-3988 2688-268X |
| language | English |
| last_indexed | 2024-12-14T19:12:01Z |
| publishDate | 2021-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | View |
| spelling | doaj.art-096e4c5d43114709bba0124f5bf3d98a2022-12-21T22:50:42ZengWileyView2688-39882688-268X2021-10-0125n/an/a10.1002/VIW.20200131Tailoring nanoparticles for targeted drug delivery: From organ to subcellular levelTingxizi Liang0Zejing Xing1Liping Jiang2Jun‐Jie Zhu3State Key Laboratory of Analytical Chemistry for life Science, School of Chemistry and Chemical Engineering Nanjing University Nanjing ChinaState Key Laboratory of Analytical Chemistry for life Science, School of Chemistry and Chemical Engineering Nanjing University Nanjing ChinaState Key Laboratory of Analytical Chemistry for life Science, School of Chemistry and Chemical Engineering Nanjing University Nanjing ChinaState Key Laboratory of Analytical Chemistry for life Science, School of Chemistry and Chemical Engineering Nanjing University Nanjing ChinaAbstract An effective dose at specific sites is of paramount importance for disease therapy. While therapeutic reagents such as small molecule drugs, nucleic acids, peptides, and proteins are suffered from degradation or clearance by physiological environment, nanomedicine has emerged to improve drug delivery efficiency due to their superior targeting ability. By tailoring the properties of nanoparticle, including size, shape, surface chemistry, site‐specific drug delivery in organ, cellular, and subcellular level could be achieved. This minireview highlights recent advances in the development of targeted drug delivery system for disease therapy.https://doi.org/10.1002/VIW.20200131disease therapynanomedicinetargeted drug delivery |
| spellingShingle | Tingxizi Liang Zejing Xing Liping Jiang Jun‐Jie Zhu Tailoring nanoparticles for targeted drug delivery: From organ to subcellular level View disease therapy nanomedicine targeted drug delivery |
| title | Tailoring nanoparticles for targeted drug delivery: From organ to subcellular level |
| title_full | Tailoring nanoparticles for targeted drug delivery: From organ to subcellular level |
| title_fullStr | Tailoring nanoparticles for targeted drug delivery: From organ to subcellular level |
| title_full_unstemmed | Tailoring nanoparticles for targeted drug delivery: From organ to subcellular level |
| title_short | Tailoring nanoparticles for targeted drug delivery: From organ to subcellular level |
| title_sort | tailoring nanoparticles for targeted drug delivery from organ to subcellular level |
| topic | disease therapy nanomedicine targeted drug delivery |
| url | https://doi.org/10.1002/VIW.20200131 |
| work_keys_str_mv | AT tingxiziliang tailoringnanoparticlesfortargeteddrugdeliveryfromorgantosubcellularlevel AT zejingxing tailoringnanoparticlesfortargeteddrugdeliveryfromorgantosubcellularlevel AT lipingjiang tailoringnanoparticlesfortargeteddrugdeliveryfromorgantosubcellularlevel AT junjiezhu tailoringnanoparticlesfortargeteddrugdeliveryfromorgantosubcellularlevel |