AhR and Wnt/β-Catenin Signaling Pathways and Their Interplay
As evolutionarily conserved signaling cascades, AhR and Wnt signaling pathways play a critical role in the control over numerous vital embryonic and somatic processes. AhR performs many endogenous functions by integrating its signaling pathway into organ homeostasis and into the maintenance of cruci...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Current Issues in Molecular Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1467-3045/45/5/248 |
| _version_ | 1797600522209853440 |
|---|---|
| author | Alevtina Y. Grishanova Lyubov S. Klyushova Maria L. Perepechaeva |
| author_facet | Alevtina Y. Grishanova Lyubov S. Klyushova Maria L. Perepechaeva |
| author_sort | Alevtina Y. Grishanova |
| collection | DOAJ |
| description | As evolutionarily conserved signaling cascades, AhR and Wnt signaling pathways play a critical role in the control over numerous vital embryonic and somatic processes. AhR performs many endogenous functions by integrating its signaling pathway into organ homeostasis and into the maintenance of crucial cellular functions and biological processes. The Wnt signaling pathway regulates cell proliferation, differentiation, and many other phenomena, and this regulation is important for embryonic development and the dynamic balance of adult tissues. AhR and Wnt are the main signaling pathways participating in the control of cell fate and function. They occupy a central position in a variety of processes linked with development and various pathological conditions. Given the importance of these two signaling cascades, it would be interesting to elucidate the biological implications of their interaction. Functional connections between AhR and Wnt signals take place in cases of crosstalk or interplay, about which quite a lot of information has been accumulated in recent years. This review is focused on recent studies about the mutual interactions of key mediators of AhR and Wnt/β-catenin signaling pathways and on the assessment of the complexity of the crosstalk between the AhR signaling cascade and the canonical Wnt pathway. |
| first_indexed | 2024-03-11T03:50:20Z |
| format | Article |
| id | doaj.art-09714d8a241a4666b20a6e227d9cb157 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-11T03:50:20Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-09714d8a241a4666b20a6e227d9cb1572023-11-18T00:56:50ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-05-014553848387610.3390/cimb45050248AhR and Wnt/β-Catenin Signaling Pathways and Their InterplayAlevtina Y. Grishanova0Lyubov S. Klyushova1Maria L. Perepechaeva2Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Str. 2, Novosibirsk 630117, RussiaInstitute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Str. 2, Novosibirsk 630117, RussiaInstitute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Str. 2, Novosibirsk 630117, RussiaAs evolutionarily conserved signaling cascades, AhR and Wnt signaling pathways play a critical role in the control over numerous vital embryonic and somatic processes. AhR performs many endogenous functions by integrating its signaling pathway into organ homeostasis and into the maintenance of crucial cellular functions and biological processes. The Wnt signaling pathway regulates cell proliferation, differentiation, and many other phenomena, and this regulation is important for embryonic development and the dynamic balance of adult tissues. AhR and Wnt are the main signaling pathways participating in the control of cell fate and function. They occupy a central position in a variety of processes linked with development and various pathological conditions. Given the importance of these two signaling cascades, it would be interesting to elucidate the biological implications of their interaction. Functional connections between AhR and Wnt signals take place in cases of crosstalk or interplay, about which quite a lot of information has been accumulated in recent years. This review is focused on recent studies about the mutual interactions of key mediators of AhR and Wnt/β-catenin signaling pathways and on the assessment of the complexity of the crosstalk between the AhR signaling cascade and the canonical Wnt pathway.https://www.mdpi.com/1467-3045/45/5/248AhRWntβ-catenincrosstalkmutual interaction |
| spellingShingle | Alevtina Y. Grishanova Lyubov S. Klyushova Maria L. Perepechaeva AhR and Wnt/β-Catenin Signaling Pathways and Their Interplay Current Issues in Molecular Biology AhR Wnt β-catenin crosstalk mutual interaction |
| title | AhR and Wnt/β-Catenin Signaling Pathways and Their Interplay |
| title_full | AhR and Wnt/β-Catenin Signaling Pathways and Their Interplay |
| title_fullStr | AhR and Wnt/β-Catenin Signaling Pathways and Their Interplay |
| title_full_unstemmed | AhR and Wnt/β-Catenin Signaling Pathways and Their Interplay |
| title_short | AhR and Wnt/β-Catenin Signaling Pathways and Their Interplay |
| title_sort | ahr and wnt β catenin signaling pathways and their interplay |
| topic | AhR Wnt β-catenin crosstalk mutual interaction |
| url | https://www.mdpi.com/1467-3045/45/5/248 |
| work_keys_str_mv | AT alevtinaygrishanova ahrandwntbcateninsignalingpathwaysandtheirinterplay AT lyubovsklyushova ahrandwntbcateninsignalingpathwaysandtheirinterplay AT marialperepechaeva ahrandwntbcateninsignalingpathwaysandtheirinterplay |