Multi-drug resistance (MDR1) gene and P-glycoprotein influence on pharmacokinetic and pharmacodymanic of therapeutic drugs

Multi-drug resistance (MDR1) gene and P-glycoprotein influence on pharmacokinetic and pharmacodymanic of therapeutic drugs

(MDR1) gene expressed in tumor cells and also in several normal tissues, such as intestine, liver, kidney, blood-brain barrier, spinal cord, and placenta. P-gp has been identified in mice, rat, bovine, monkey, rodents, and human beings and has been receiving a particular clinical relevance because t...

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Bibliographic Details
Main Authors:	Linardi Renata Lehn, Natalini Cláudio Corrêa
Format:	Article
Language:	English
Published:	Universidade Federal de Santa Maria 2006-01-01
Series:	Ciência Rural
Subjects:	MDR1 gene P-glycoprotein therapeutics pharmacology
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100056

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