Neurorestoration Approach by Biomaterials in Ischemic Stroke
Ischemic stroke (IS) is the leading cause of disability in the western world, assuming a high socio-economic cost. One of the most used strategies in the last decade has been biomaterials, which have been initially used with a structural support function. They have been perfected, different compound...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00431/full |
| _version_ | 1818019858294505472 |
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| author | Noelia Esteban-Garcia Cristina Nombela Cristina Nombela Javier Garrosa Fernando J. Rascón-Ramirez Juan Antonio Barcia Juan Antonio Barcia Leyre Sánchez-Sánchez-Rojas |
| author_facet | Noelia Esteban-Garcia Cristina Nombela Cristina Nombela Javier Garrosa Fernando J. Rascón-Ramirez Juan Antonio Barcia Juan Antonio Barcia Leyre Sánchez-Sánchez-Rojas |
| author_sort | Noelia Esteban-Garcia |
| collection | DOAJ |
| description | Ischemic stroke (IS) is the leading cause of disability in the western world, assuming a high socio-economic cost. One of the most used strategies in the last decade has been biomaterials, which have been initially used with a structural support function. They have been perfected, different compounds have been combined, and they have been used together with cell therapy or controlled release chemical compounds. This double function has driven them as potential candidates for the chronic treatment of IS. In fact, the most developed are in different phases of clinical trial. In this review, we will show the ischemic scenario and address the most important criteria to achieve a successful neuroreparation from the point of view of biomaterials. The spontaneous processes that are activated and how to enhance them is one of the keys that contribute to the success of the therapeutic approach. In addition, the different routes of administration and how they affect the design of biomaterials are analyzed. Future perspectives show where this broad scientific field is heading, which advances every day with the help of technology and advanced therapies. |
| first_indexed | 2024-04-14T07:57:14Z |
| format | Article |
| id | doaj.art-097399723c0749619aeafac84627cbed |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-14T07:57:14Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-097399723c0749619aeafac84627cbed2022-12-22T02:04:59ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-05-011410.3389/fnins.2020.00431525832Neurorestoration Approach by Biomaterials in Ischemic StrokeNoelia Esteban-Garcia0Cristina Nombela1Cristina Nombela2Javier Garrosa3Fernando J. Rascón-Ramirez4Juan Antonio Barcia5Juan Antonio Barcia6Leyre Sánchez-Sánchez-Rojas7Regenerative Medicine and Advanced Therapies Lab, Instituto de Investigación Sanitaria San Carlos, Clínico San Carlos Hospital, Madrid, SpainRegenerative Medicine and Advanced Therapies Lab, Instituto de Investigación Sanitaria San Carlos, Clínico San Carlos Hospital, Madrid, SpainDepartment of Biological and Health Psychology, Universidad Autónoma de Madrid, Madrid, SpainRegenerative Medicine and Advanced Therapies Lab, Instituto de Investigación Sanitaria San Carlos, Clínico San Carlos Hospital, Madrid, SpainNeurosurgery Department, Clínico San Carlos Hospital, Madrid, SpainNeurosurgery Department, Clínico San Carlos Hospital, Madrid, SpainChair of Neurosurgery Department, Clínico San Carlos Hospital, Madrid, SpainRegenerative Medicine and Advanced Therapies Lab, Instituto de Investigación Sanitaria San Carlos, Clínico San Carlos Hospital, Madrid, SpainIschemic stroke (IS) is the leading cause of disability in the western world, assuming a high socio-economic cost. One of the most used strategies in the last decade has been biomaterials, which have been initially used with a structural support function. They have been perfected, different compounds have been combined, and they have been used together with cell therapy or controlled release chemical compounds. This double function has driven them as potential candidates for the chronic treatment of IS. In fact, the most developed are in different phases of clinical trial. In this review, we will show the ischemic scenario and address the most important criteria to achieve a successful neuroreparation from the point of view of biomaterials. The spontaneous processes that are activated and how to enhance them is one of the keys that contribute to the success of the therapeutic approach. In addition, the different routes of administration and how they affect the design of biomaterials are analyzed. Future perspectives show where this broad scientific field is heading, which advances every day with the help of technology and advanced therapies.https://www.frontiersin.org/article/10.3389/fnins.2020.00431/fullneurorestorationrepairbiomaterialsstrokecell therapy |
| spellingShingle | Noelia Esteban-Garcia Cristina Nombela Cristina Nombela Javier Garrosa Fernando J. Rascón-Ramirez Juan Antonio Barcia Juan Antonio Barcia Leyre Sánchez-Sánchez-Rojas Neurorestoration Approach by Biomaterials in Ischemic Stroke Frontiers in Neuroscience neurorestoration repair biomaterials stroke cell therapy |
| title | Neurorestoration Approach by Biomaterials in Ischemic Stroke |
| title_full | Neurorestoration Approach by Biomaterials in Ischemic Stroke |
| title_fullStr | Neurorestoration Approach by Biomaterials in Ischemic Stroke |
| title_full_unstemmed | Neurorestoration Approach by Biomaterials in Ischemic Stroke |
| title_short | Neurorestoration Approach by Biomaterials in Ischemic Stroke |
| title_sort | neurorestoration approach by biomaterials in ischemic stroke |
| topic | neurorestoration repair biomaterials stroke cell therapy |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00431/full |
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