Crosstalk signaling between alveoli and capillaries
Crosstalk signaling between the closely juxtaposed epithelial and endothelial membranes of pulmonary alveoli establishes the lung’s immune defense against inhaled and blood-borne pathogens. The crosstalk can occur in a forward direction, as from alveolus to capillary, or in a reverse direction, as f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-06-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045894018783735 |
| _version_ | 1811316865264254976 |
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| author | Rebecca F. Hough Sunita Bhattacharya Jahar Bhattacharya |
| author_facet | Rebecca F. Hough Sunita Bhattacharya Jahar Bhattacharya |
| author_sort | Rebecca F. Hough |
| collection | DOAJ |
| description | Crosstalk signaling between the closely juxtaposed epithelial and endothelial membranes of pulmonary alveoli establishes the lung’s immune defense against inhaled and blood-borne pathogens. The crosstalk can occur in a forward direction, as from alveolus to capillary, or in a reverse direction, as from capillary to alveolus. The crosstalk direction likely depends on the site at which pathogens first initiate signaling. Thus, forward crosstalk may occur when inhaled pathogens encounter the alveolar epithelium, while reverse crosstalk may result from interactions of blood-borne pathogens with the endothelium. Here, we review the factors that regulate these two directions of signaling. |
| first_indexed | 2024-04-13T11:56:41Z |
| format | Article |
| id | doaj.art-0975cac258884b47a132ddaf9d05c57e |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-04-13T11:56:41Z |
| publishDate | 2018-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-0975cac258884b47a132ddaf9d05c57e2022-12-22T02:47:54ZengWileyPulmonary Circulation2045-89402018-06-01810.1177/2045894018783735Crosstalk signaling between alveoli and capillariesRebecca F. Hough0Sunita Bhattacharya1Jahar Bhattacharya2Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, NY, USADepartment of Pediatrics, Columbia University College of Physicians & Surgeons, New York, NY, USADepartment of Medicine, Columbia University College of Physicians & Surgeons, New York, NY, USACrosstalk signaling between the closely juxtaposed epithelial and endothelial membranes of pulmonary alveoli establishes the lung’s immune defense against inhaled and blood-borne pathogens. The crosstalk can occur in a forward direction, as from alveolus to capillary, or in a reverse direction, as from capillary to alveolus. The crosstalk direction likely depends on the site at which pathogens first initiate signaling. Thus, forward crosstalk may occur when inhaled pathogens encounter the alveolar epithelium, while reverse crosstalk may result from interactions of blood-borne pathogens with the endothelium. Here, we review the factors that regulate these two directions of signaling.https://doi.org/10.1177/2045894018783735 |
| spellingShingle | Rebecca F. Hough Sunita Bhattacharya Jahar Bhattacharya Crosstalk signaling between alveoli and capillaries Pulmonary Circulation |
| title | Crosstalk signaling between alveoli and capillaries |
| title_full | Crosstalk signaling between alveoli and capillaries |
| title_fullStr | Crosstalk signaling between alveoli and capillaries |
| title_full_unstemmed | Crosstalk signaling between alveoli and capillaries |
| title_short | Crosstalk signaling between alveoli and capillaries |
| title_sort | crosstalk signaling between alveoli and capillaries |
| url | https://doi.org/10.1177/2045894018783735 |
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