Recent Advances in the Application of ATRP in the Synthesis of Drug Delivery Systems
Advances in atom transfer radical polymerization (ATRP) have enabled the precise design and preparation of nanostructured polymeric materials for a variety of biomedical applications. This paper briefly summarizes recent developments in the synthesis of bio-therapeutics for drug delivery based on li...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/5/1234 |
| _version_ | 1797614487821352960 |
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| author | Matylda Szewczyk-Łagodzińska Andrzej Plichta Maciej Dębowski Sebastian Kowalczyk Anna Iuliano Zbigniew Florjańczyk |
| author_facet | Matylda Szewczyk-Łagodzińska Andrzej Plichta Maciej Dębowski Sebastian Kowalczyk Anna Iuliano Zbigniew Florjańczyk |
| author_sort | Matylda Szewczyk-Łagodzińska |
| collection | DOAJ |
| description | Advances in atom transfer radical polymerization (ATRP) have enabled the precise design and preparation of nanostructured polymeric materials for a variety of biomedical applications. This paper briefly summarizes recent developments in the synthesis of bio-therapeutics for drug delivery based on linear and branched block copolymers and bioconjugates using ATRP, which have been tested in drug delivery systems (DDSs) over the past decade. An important trend is the rapid development of a number of smart DDSs that can release bioactive materials in response to certain external stimuli, either physical (e.g., light, ultrasound, or temperature) or chemical factors (e.g., changes in pH values and/or environmental redox potential). The use of ATRPs in the synthesis of polymeric bioconjugates containing drugs, proteins, and nucleic acids, as well as systems applied in combination therapies, has also received considerable attention. |
| first_indexed | 2024-03-11T07:12:39Z |
| format | Article |
| id | doaj.art-097671392f5b4640b35b00cb0d82c71b |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T07:12:39Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-097671392f5b4640b35b00cb0d82c71b2023-11-17T08:27:59ZengMDPI AGPolymers2073-43602023-02-01155123410.3390/polym15051234Recent Advances in the Application of ATRP in the Synthesis of Drug Delivery SystemsMatylda Szewczyk-Łagodzińska0Andrzej Plichta1Maciej Dębowski2Sebastian Kowalczyk3Anna Iuliano4Zbigniew Florjańczyk5Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandAdvances in atom transfer radical polymerization (ATRP) have enabled the precise design and preparation of nanostructured polymeric materials for a variety of biomedical applications. This paper briefly summarizes recent developments in the synthesis of bio-therapeutics for drug delivery based on linear and branched block copolymers and bioconjugates using ATRP, which have been tested in drug delivery systems (DDSs) over the past decade. An important trend is the rapid development of a number of smart DDSs that can release bioactive materials in response to certain external stimuli, either physical (e.g., light, ultrasound, or temperature) or chemical factors (e.g., changes in pH values and/or environmental redox potential). The use of ATRPs in the synthesis of polymeric bioconjugates containing drugs, proteins, and nucleic acids, as well as systems applied in combination therapies, has also received considerable attention.https://www.mdpi.com/2073-4360/15/5/1234drug delivery systemdrug nanocarriermicelleATRPblock copolymerpolymer–drug conjugate |
| spellingShingle | Matylda Szewczyk-Łagodzińska Andrzej Plichta Maciej Dębowski Sebastian Kowalczyk Anna Iuliano Zbigniew Florjańczyk Recent Advances in the Application of ATRP in the Synthesis of Drug Delivery Systems Polymers drug delivery system drug nanocarrier micelle ATRP block copolymer polymer–drug conjugate |
| title | Recent Advances in the Application of ATRP in the Synthesis of Drug Delivery Systems |
| title_full | Recent Advances in the Application of ATRP in the Synthesis of Drug Delivery Systems |
| title_fullStr | Recent Advances in the Application of ATRP in the Synthesis of Drug Delivery Systems |
| title_full_unstemmed | Recent Advances in the Application of ATRP in the Synthesis of Drug Delivery Systems |
| title_short | Recent Advances in the Application of ATRP in the Synthesis of Drug Delivery Systems |
| title_sort | recent advances in the application of atrp in the synthesis of drug delivery systems |
| topic | drug delivery system drug nanocarrier micelle ATRP block copolymer polymer–drug conjugate |
| url | https://www.mdpi.com/2073-4360/15/5/1234 |
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