Antimicrobial Peptides: A Potent Alternative to Antibiotics
Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been de...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/10/9/1095 |
| _version_ | 1797520435358728192 |
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| author | Mariam Rima Mohamad Rima Ziad Fajloun Jean-Marc Sabatier Burkhard Bechinger Thierry Naas |
| author_facet | Mariam Rima Mohamad Rima Ziad Fajloun Jean-Marc Sabatier Burkhard Bechinger Thierry Naas |
| author_sort | Mariam Rima |
| collection | DOAJ |
| description | Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. This review focuses on their use against ESKAPE bacteria, especially in biofilm treatments, their synergistic activity, and their application as prophylactic agents. Limitations and challenges restricting therapeutic applications are highlighted, and solutions for each challenge are evaluated to analyze whether antimicrobial peptides could replace antibiotics in the near future. |
| first_indexed | 2024-03-10T07:56:43Z |
| format | Article |
| id | doaj.art-0976d454ef2a4fc599e603d14d03a027 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T07:56:43Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-0976d454ef2a4fc599e603d14d03a0272023-11-22T11:46:12ZengMDPI AGAntibiotics2079-63822021-09-01109109510.3390/antibiotics10091095Antimicrobial Peptides: A Potent Alternative to AntibioticsMariam Rima0Mohamad Rima1Ziad Fajloun2Jean-Marc Sabatier3Burkhard Bechinger4Thierry Naas5Team ReSIST, INSERM U1184, School of Medicine Université Paris-Saclay, 94270 Le Kremlin-Bicetre, FranceLaboratory of Applied Biotechnology, Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, Tripoli 1300, LebanonLaboratory of Applied Biotechnology, Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, Tripoli 1300, LebanonInstitut de Neuro Physiopathologie, UMR7051, Aix-Marseille Université, Faculté de Pharmacie, 27 Boulevard Jean Moulin, 13005 Marseille, FranceInstitut de Chimie de Strasbourg, CNRS, UMR7177, University of Strasbourg, 67008 Strasbourg, FranceTeam ReSIST, INSERM U1184, School of Medicine Université Paris-Saclay, 94270 Le Kremlin-Bicetre, FranceAntimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. This review focuses on their use against ESKAPE bacteria, especially in biofilm treatments, their synergistic activity, and their application as prophylactic agents. Limitations and challenges restricting therapeutic applications are highlighted, and solutions for each challenge are evaluated to analyze whether antimicrobial peptides could replace antibiotics in the near future.https://www.mdpi.com/2079-6382/10/9/1095antimicrobial peptidesantibiotic resistancemultidrug resistanceESKAPE |
| spellingShingle | Mariam Rima Mohamad Rima Ziad Fajloun Jean-Marc Sabatier Burkhard Bechinger Thierry Naas Antimicrobial Peptides: A Potent Alternative to Antibiotics Antibiotics antimicrobial peptides antibiotic resistance multidrug resistance ESKAPE |
| title | Antimicrobial Peptides: A Potent Alternative to Antibiotics |
| title_full | Antimicrobial Peptides: A Potent Alternative to Antibiotics |
| title_fullStr | Antimicrobial Peptides: A Potent Alternative to Antibiotics |
| title_full_unstemmed | Antimicrobial Peptides: A Potent Alternative to Antibiotics |
| title_short | Antimicrobial Peptides: A Potent Alternative to Antibiotics |
| title_sort | antimicrobial peptides a potent alternative to antibiotics |
| topic | antimicrobial peptides antibiotic resistance multidrug resistance ESKAPE |
| url | https://www.mdpi.com/2079-6382/10/9/1095 |
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