Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuries
With the rising incidence of cancer, radiotherapy has become an increasingly popular treatment modality. However, radiation-induced skin injuries (RSIs) have emerged as a commonly reported side effect of radiotherapy, thereby presenting a significant challenge in the field of radiotherapy. In this s...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-12-01
|
| Series: | Journal of Applied Biomaterials & Functional Materials |
| Online Access: | https://doi.org/10.1177/22808000231218996 |
| _version_ | 1797378923544182784 |
|---|---|
| author | Jingying Wang Lin Gao Jianbo Song Sijin Li |
| author_facet | Jingying Wang Lin Gao Jianbo Song Sijin Li |
| author_sort | Jingying Wang |
| collection | DOAJ |
| description | With the rising incidence of cancer, radiotherapy has become an increasingly popular treatment modality. However, radiation-induced skin injuries (RSIs) have emerged as a commonly reported side effect of radiotherapy, thereby presenting a significant challenge in the field of radiotherapy. In this study, we report the successful synthesis of a photosensitive hydrogel via amide reaction for grafting the photosensitive group, methacrylate anhydride (MA), onto chitosan (CHI) and gelatin (GEL), with subsequent physical incorporation of epigallocatechin gallate (EGCG). The resulting composite photosensitive hydrogels exhibited favorable swelling properties, rheological properties, and biocompatibility, which promote angiogenesis and demonstrate notable therapeutic efficacy against RSIs. These findings provide valuable insights into the clinical utility of EGCG composite hydrogels for the effective management of RSIs. |
| first_indexed | 2024-03-08T20:14:39Z |
| format | Article |
| id | doaj.art-0977970fdb2a455389a0a5e1e3c1232d |
| institution | Directory Open Access Journal |
| issn | 2280-8000 |
| language | English |
| last_indexed | 2024-03-08T20:14:39Z |
| publishDate | 2023-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Applied Biomaterials & Functional Materials |
| spelling | doaj.art-0977970fdb2a455389a0a5e1e3c1232d2023-12-22T19:06:06ZengSAGE PublishingJournal of Applied Biomaterials & Functional Materials2280-80002023-12-012110.1177/22808000231218996Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuriesJingying Wang0Lin Gao1Jianbo Song2Sijin Li3Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of ChinaCancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, People’s Republic of ChinaCollaborative Innovation Center For Molecular Imaging, Shanxi Medical University, Taiyuan, People’s Republic of ChinaWith the rising incidence of cancer, radiotherapy has become an increasingly popular treatment modality. However, radiation-induced skin injuries (RSIs) have emerged as a commonly reported side effect of radiotherapy, thereby presenting a significant challenge in the field of radiotherapy. In this study, we report the successful synthesis of a photosensitive hydrogel via amide reaction for grafting the photosensitive group, methacrylate anhydride (MA), onto chitosan (CHI) and gelatin (GEL), with subsequent physical incorporation of epigallocatechin gallate (EGCG). The resulting composite photosensitive hydrogels exhibited favorable swelling properties, rheological properties, and biocompatibility, which promote angiogenesis and demonstrate notable therapeutic efficacy against RSIs. These findings provide valuable insights into the clinical utility of EGCG composite hydrogels for the effective management of RSIs.https://doi.org/10.1177/22808000231218996 |
| spellingShingle | Jingying Wang Lin Gao Jianbo Song Sijin Li Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuries Journal of Applied Biomaterials & Functional Materials |
| title | Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuries |
| title_full | Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuries |
| title_fullStr | Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuries |
| title_full_unstemmed | Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuries |
| title_short | Study of EGCG composite hydrogel for the treatment of radiation-induced skin injuries |
| title_sort | study of egcg composite hydrogel for the treatment of radiation induced skin injuries |
| url | https://doi.org/10.1177/22808000231218996 |
| work_keys_str_mv | AT jingyingwang studyofegcgcompositehydrogelforthetreatmentofradiationinducedskininjuries AT lingao studyofegcgcompositehydrogelforthetreatmentofradiationinducedskininjuries AT jianbosong studyofegcgcompositehydrogelforthetreatmentofradiationinducedskininjuries AT sijinli studyofegcgcompositehydrogelforthetreatmentofradiationinducedskininjuries |